Association of dyslipidemia with lumbar disc herniation: A case-control study

Abstract

Purpose: The purpose of this study was to investigate the relationship between dyslipidemia and lumbar disc herniation (LDH). Methods: A total of 269 patients with LDH and 269 patients with lumbar vertebral fracture (LVF) were enrolled in this study. The total cholesterol level (TC), Low-density lipoprotein-cholesterol level (LDL-C), triglyceride level (TG), High-density lipoprotein-cholesterol level (HDL-C), nonHDL-C, ApoB level, ApoB A1 level and arteriosclerosis index (AI) were measured.The 269 patients with single-level LDH underwent surgery were enrolled as the disc herniation group and 269 patients who underwent surgical treatment for spine fracture(Pfirrmann Grading Systems of Grade I or II) during the same period were enrolled as the control group. The participants in the control group were selected randomly and matched for age (within 5 years) and sex. Results: In this analysis, we found that the level of TC, TG, LDL, nonHDL-C, APOB, and APOA1 in patients with LDH was significantly higher compared with that of the controls. The proportion of high TC, borderline high-total cholesterol, high LDL-C,high TG, borderline high LDL-C, high APO B, high AI and high ApoB/ApoA1 in the LDH group was significantly higher relative to that of the control group. The ratio of TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, nonHDL-C/HDL-C and ApoB/ApoA1 in the LDH group was significantly higher compared with that of the control group. Multivariate logistic regression analysis indicated that the levels of serum LDL-C, TC, TG, nonHDL-C, Apo B and AI were positively associated with the risk of LDH and were independent risk factors predicting LDH development. Conclusion: Overall, this study indicates that TC, TG, LDL-C, nonHDL-C, Apo B, and AI levels in may increase the risk of LDH.Dyslipidemia may be associated with cartilage endplate (CEP) degeneration and hence may be involved in the pathological process of intervertebral disc degeneration (IVDD). Moreover, dyslipidemia may be a useful predictor of IVDD.

Dyslipidemia Is Positively Associated with Chronic Low Back Pain in Korean Women: Korean National Health and Nutrition Examination Survey 2010–2012

“…A case-control study of 269 patients found an increased risk of intervertebral disc degeneration in the setting of dyslipidemia with high TG (OR, 1.753; 95% CI, 1.151, 2.699; p = 0.009), high LDL (OR, 1.952; 95% CI, 1.530, 2.490; p < 0.001), or high total cholesterol (OR, 3.580; 95% CI, 2.182, 55.876; p < 0.001). Disc degeneration was associated with a significantly higher incidence of lumbar disc herniation, and consequently CLBP [ 25 ]. Our study also confirmed the association between LBP and dyslipidemia.…”

“…Some studies have found a meaningful association between diabetes and CLBP [ 9 , 17 , 18 , 19 ], whereas others have reported no relationship [ 20 , 21 ]. Similarly, some studies have suggested a positive relationship between dyslipidemia and CLBP [ 10 , 22 , 23 , 24 , 25 ], whereas others have found no association between them [ 23 , 26 , 27 ]. Based on the results of these published studies, the association between CLBP and chronic diseases is still inconsistent.…”