Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort

Lambert, Katrina A.; Markevych, Iana; Yang, Bo‐Yi; Bauer, Carl‐Peter; Berdel, Dietrich; Berg, Andrea von; Bergmann, Karl‐Christian; Lodge, Caroline; Koletzko, Sibylle; Prendergast, Luke A.; Schikowski, Tamara; Schulz, Holger; Werchan, Matthias; Heinrich, Joachim; Standl, Marie; Erbas, Bircan

doi:10.1016/j.scitotenv.2020.143006

Cited by 11 publications

(13 citation statements)

References 45 publications

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“…Similarly, Lambert et al [ 82 ] observed a reduction in FEV 1 and FVC with increasing concentrations of tree pollen at lag 1 and lag 3 in 8-year-old ‘high-risk’ children residing in Sydney, Australia [ 82 ]. The same authors investigated similar relationships in adolescents of the GINIplus and LISA cohorts in Germany, but observed the association to be present only in those who were pollen sensitised [ 30 ]. Using an unsupervised approach, another recent study of the PARIS cohort demonstrated that children in the ‘grass pollen’ cluster (i.e., moderate grass pollen exposure and low air pollution exposure) had reductions in FEV 1 and FVC, when compared to children in the ‘low exposure’ cluster (i.e., no pollen exposure and low air pollution exposure) [ 83 ].…”

Section: Short-term Impact Of Pollen On Adverse Respiratory Outcomesmentioning

confidence: 99%

“…Lambert et al [ 30 , 82 ] performed two studies investigating effect modification by residential greenness for the association between ambient pollen concentration and airway inflammation. Both studies found evidence of interaction, such that those living in areas of higher residential greenness were at-risk of increased airway inflammation with increasing ambient pollen concentrations.…”

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

“…Both studies found evidence of interaction, such that those living in areas of higher residential greenness were at-risk of increased airway inflammation with increasing ambient pollen concentrations. However, only one of the studies reported clinically meaningful effect modification (e.g., FeNO = 0.12%, 95% CI = 0.05, 0.18 for every 15 grains/m 3 increase in birch pollen at lag 1 in high residential greenness areas), possibly because this study had more statistical power [ 30 ].…”

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

“…The impact of short-term outdoor pollen exposure on respiratory health in those with asthma [ 83 ], AR [ 56 ] or pollen sensitisation [ 30 , 89 ] has been extensively studied and established. Recent studies, including our own, have supported this by showing stronger associations between ambient pollen levels and lung function in those with asthma [ 29 , 83 ], AR [ 29 ] and/or pollen sensitisation [ 29 , 30 ].…”

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

“…We found increased grass pollen concentrations to be associated with increased eosinophilic airway inflammation (measured by the fractional exhaled nitric oxide, FeNO) 1–2 days after exposure (i.e., at lag 1 and lag 2) [ 29 ]. Lambert and colleagues [ 30 ] also assessed similar associations, but used data on adolescents from two German birth cohorts, the GINIplus and LISA. They observed the strongest associations between grass pollen concentrations and FeNO to be on the same day (lag 0) and lag 1.…”

Section: Introductionmentioning

confidence: 99%

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A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen

Idrose

Lodge

Erbas

et al. 2022

IJERPH

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Respiratory diseases such as asthma, allergic rhinitis (AR) and chronic obstructive pulmonary disease (COPD) affect millions worldwide and pose a significant global public health burden. Over the years, changes in land use and climate have increased pollen quantity, allergenicity and duration of the pollen season, thus increasing its impact on respiratory disease. Many studies have investigated the associations between short-term ambient pollen (i.e., within days or weeks of exposure) and respiratory outcomes. Here, we reviewed the current evidence on the association between short-term outdoor pollen exposure and thunderstorm asthma (TA), asthma and COPD hospital presentations, general practice (GP) consultations, self-reported respiratory symptoms, lung function changes and their potential effect modifiers. The literature suggests strong evidence of an association between ambient pollen concentrations and almost all respiratory outcomes mentioned above, especially in people with pre-existing respiratory diseases. However, the evidence on sub-clinical lung function changes, COPD, and effect modifiers other than asthma, hay fever and pollen sensitisation are still scarce and requires further exploration. Better understanding of the implications of pollen on respiratory health can aid healthcare professionals to implement appropriate management strategies.

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Section: Short-term Impact Of Pollen On Adverse Respiratory Outcomesmentioning

confidence: 99%

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

Section: Evidence On Potential Effect Modifiers Of the Above Associat...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen

Idrose

Lodge

Erbas

et al. 2022

IJERPH

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Acute exposure to pollen and airway inflammation in adolescents

Nassikas,

Luttmann‐Gibson,

Rifas‐Shiman

et al. 2024

Pediatric Pulmonology

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IntroductionPollen exposure is known to exacerbate allergic asthma and allergic rhinitis symptoms, yet few studies have investigated if exposure to pollen affects lung function or airway inflammation in healthy children.MethodsWe evaluated the extent to which higher pollen exposure was associated with differences in airway inflammation and lung function among 490 early adolescent participants (mean age of 12.9 years) in Project Viva, a prebirth cohort based in Massachusetts. We obtained regional daily total pollen counts, including tree, grass, and weed pollen, from a Rotorod pollen counter. We evaluated associations of 3‐ and 7‐day moving averages of pollen with fractional exhaled nitric oxide (FeNO) and lung function using linear regression models and evaluated the linearity of associations with penalized splines. We tested if associations of pollen with FeNO and lung function were modified by current asthma diagnosis, history of allergic rhinitis, aeroallergen sensitivity, temperature, precipitation, and air pollution.ResultsThree‐ and 7‐day median pollen concentrations were 19.0 grains/m3 (IQR: 73.4) and 20.9 grains/m3 (IQR: 89.7). In main models, higher concentrations of total pollen over the preceding 3 and 7 days were associated with a 4.6% (95% CI: 0.1,9.2) and 7.4% (95% CI: 0.9,14.3) higher FeNO per IQR of pollen, respectively. We did not find associations of pollen with lung function in main models. Asthma, allergic rhinitis, precipitation, and air pollution (nitrogen dioxide and ozone) modified associations of pollen with lung function (Pinteraction < 0.1), while temperature, sex, and aeroallergen sensitization did not.ConclusionShort‐term exposure to pollen was associated with higher FeNO in early adolescents, even in the absence of allergic sensitization and asthma.

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Wie gefährlich ist der Anstieg von Gräserpollen durch den Klimawandel?

Kempe¹

2022

Pneumo News

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Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort

Cited by 11 publications

References 45 publications

A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen

A Review of the Respiratory Health Burden Attributable to Short-Term Exposure to Pollen

Acute exposure to pollen and airway inflammation in adolescents

Wie gefährlich ist der Anstieg von Gräserpollen durch den Klimawandel?

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