Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies

Kenmoe, Sébastien; Kengne‐Nde, Cyprien; Modiyinji, Abdou Fatawou; Bigna, Jean Joël; Njouom, Richard

doi:10.1371/journal.pone.0231816

Cited by 8 publications

(7 citation statements)

References 60 publications

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“…Some studies found an increased risk of allergic sensitization 41 , other reported protection against allergic sensitization through the stimulation of Th-1 cytokine production 42 , whereas others did not find any influence of childhood viral LRTI on the risk of subsequent atopy 11 . The results of a recent systematic review and meta-analysis suggest, as ours, that there is no association between viral LRTI at < 5 years and positivity of skin prick test or atopic dermatitis, but, in contrast, there is a higher frequency of allergic rhinoconjunctivitis (OR = 1.7 [95%CI = 1.1–2.9]) 43 .…”

Section: Discussionsupporting

confidence: 55%

Lung function, allergic sensitization and asthma in school-aged children after viral-coinfection bronchiolitis

Ruiz

Calvo

Pozo

et al. 2022

Sci Rep

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Our main objective was to compare the lung function, the rate of allergic sensitization and the prevalence of asthma at 7–9 years in children hospitalized for bronchiolitis with viral coinfection versus single viral infection. Observational study in children with previous bronchiolitis and current age 7–9 years. Clinical data were collected. Fraction of exhaled nitric oxide (FeNO) determination, spirometry and skin prick test for common aeroallergens were performed. A total of 181 children hospitalized for bronchiolitis (40 coinfections and 141 single infections), with median age of 8.3 years (IQR:7.5–9.1) were included. Single-HRV-infections showed lower basal FEV1(%) than coinfections (p = 0.04) and lower z-score FEV1 than single-RSV-infections (p = 0.04) or coinfections (p = 0.02). Also, single-HRV-infections had lower post-bronchodilator FEV1(%) and z-score FEV1 values than coinfections (p = 0.03 and p = 0.03). Single-HRV-bronchiolitis was an independent risk factor for FEV1 < 80% (p = 0.007). FeNO value > 25 ppb was detected in 21(12.5%) cases, without differences between viral groups (p = 0.768). The prevalence of allergic sensitization was similar in coinfections (31.4%) versus single infections (38.7%), (p = 0.428). The highest frequency of allergic rhinitis was observed in single-HRV patients (p = 0.004). The respiratory morbidity at 7–9 years of coinfected patients was similar to the single-HRV ones. In contrast, the likelihood of current asthma was up to 5 times higher in RSV/HRV coinfections than in the single-RSV-infections ones (p = 0.012). The respiratory morbidity at 7–9 years of age after severe bronchiolitis is significantly higher in single-HRV or viral coinfection patients that in single-RSV ones. Single-HRV-bronchiolitis is independently associated with lower lung function at school-age.

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Section: Discussionsupporting

confidence: 55%

Lung function, allergic sensitization and asthma in school-aged children after viral-coinfection bronchiolitis

Ruiz

Calvo

Pozo

et al. 2022

Sci Rep

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“…Sensitivity analyses that included only studies with a low risk of bias and studies comparable with regard to confounding factors were performed to enhance the accuracy of our results. We determined the comparability of studies with confounding factors using Chi-square, Fisher or Student's T-test as reported previously [32].…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders

et al. 2021

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Introduction Meta-analyses conducted so far on the association between diabetes mellitus (DM) and the tuberculosis (TB) development risk did not sufficiently take confounders into account in their estimates. The objective of this systematic review was to determine whether DM is associated with an increased risk of developing TB with a sensitivity analyses incorporating a wider range of confounders including age, gender, alcohol consumption, smoke exposure, and other comorbidities. Methods Pubmed, Embase, Web of Science and Global Index Medicus were queried from inception until October 2020. Without any restriction to time of study, geographical location, and DM and TB diagnosis approaches, all observational studies that presented data for associations between DM and TB were included. Studies with no abstract or complete text, duplicates, and studies with wrong designs (review, case report, case series, comment on an article, and editorial) or populations were excluded. The odds ratios (OR) and their 95% confidence intervals were estimated by a random-effect model. Results The electronic and manual searches yielded 12,796 articles of which 47 were used in our study (23 case control, 14 cross-sectional and 10 cohort studies) involving 503,760 cases (DM or TB patients) and 3,596,845 controls. The size of the combined effect of TB risk in the presence of DM was OR = 2.3, 95% CI = [2.0–2.7], I2 = 94.2%. This statistically significant association was maintained in cohort (OR = 2.0, CI 95% = [1.5–2.4], I2 = 94.3%), case control (OR = 2.4, CI 95% = [2.0–2.9], I2 = 93.0%) and cross-sectional studies (OR = 2.5, CI 95% = [1.8–3.5], I2 = 95.2%). The association between DM and TB was also maintained in the sensitivity analysis including only studies with similar proportions of confounders between cases and controls. The substantial heterogeneity observed was mainly explained by the differences between geographic regions. Conclusions DM is associated with an increased risk of developing latent and active TB. To further explore the role of DM in the development of TB, more investigations of the biological mechanisms by which DM increases the risk of TB are needed. Review registration PROSPERO, CRD42021216815.

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“…Um estudo americano, mostrou associação significativa com o uso de antibióticos (OR 1.42); H2RA (OR 1.48) e IBP (OR 1.15) e o desenvolvimento de alergia ocular 30 . O uso de antibiótico e paracetamol no primeiro ano de vida, também se apresentou como fator de risco para conjuntivite alérgica na criança (6-7 anos) e adolescente (13-14 anos) 19,35 , porém a infecção de trato respiratório inferior não teve associação 22 .…”

Section: Discussionunclassified

Fatores Desencadeantes Da Conjuntivite Alérgica Na Criança E Adolescente: Revisão Integrativa

Furtado¹,

Linard²

2022

RECIMA21

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Objetivo: mapear os fatores desencadeantes da conjuntivite alérgica em crianças e adolescentes. Método: revisão integrativa, foi realizada em 6 passos - elaboração da pergunta norteadora; busca ou amostragem na literatura; coleta de dados; análise crítica dos estudos incluídos; discussão dos resultados e apresentação da revisão integrativa. Foi utilizada a extensão do checklist PRISMA-ScR para busca e seleção dos artigos, mediante Descritores em Ciência da Saúde e Medical Subject Headings, nas bases de dados LILACS, via Biblioteca Virtual em Saúde, MEDLINE, via PubMed e ScienceDirect. Foi considerado como critério de inclusão estudos com crianças (até 10 anos) e adolescentes (10 a 19 anos) que abordem fatores desencadeantes de conjuntivite alérgica. A seleção dos estudos foi realizada por dois pesquisadores independentes. Os artigos foram organizados dentro do software Mendeley e os resultados apresentados em quadros, com posterior discussão narrativa. Resultado: A partir da busca primária, foram encontrados 4769 artigos e após aplicação dos critérios de exclusão e inclusão, ficaram 17 artigos elegíveis para esta revisão integrativa. A maior parte das publicações foram feitas na Ásia (9) e realizada nos anos de 2018-2020. Os principais fatores de risco encontrados foram: poeira (8), pelo de animal (5), ácaro (4), uso de antibióticos na infância e histórico de outras alergias (3). Considerações finais: a maioria dos fatores de risco encontrados são preveníveis, então deve-se realizar a identificação desses fatores e buscar medidas para diminuir a sua incidência.

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Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies

Cited by 8 publications

References 60 publications

Lung function, allergic sensitization and asthma in school-aged children after viral-coinfection bronchiolitis

Lung function, allergic sensitization and asthma in school-aged children after viral-coinfection bronchiolitis

Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders

Fatores Desencadeantes Da Conjuntivite Alérgica Na Criança E Adolescente: Revisão Integrativa

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