Association of eating behaviour with clock gene polymorphism 3111 T &gt; C in children based on nutritional status

Valladares, Macarena; Chaput, J-P; Vásquez, Sofía; Astorga, Carolina Pino; Obregón, Ana María

doi:10.1080/03014460.2019.1706764

Cited by 3 publications

(5 citation statements)

References 15 publications

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“…With regard to the minor allele (G) of rs1801260, several studies of this SNP in the general adult population and school-age children identified a similar effect as did the current study, which suggest the minor allele of rs1801260 is linked to higher BMI [10,14,15,23,24]. The minor allele of rs1801260 was related to the expression level of the CLOCK gene and consequently might affect the CLOCK-related obesogenic mechanism.…”

Section: Plos Onesupporting

confidence: 80%

“…We specified the simulation (n = 1000) with random effects for the intercept, fixed treatment effects and fixed effects for the genotypes. Previous studies indicated the difference of BMI z-scores between the C allele carriers and noncarriers of the CLOCK SNP was around 0.4, and the difference between the AA allele carriers and TT allele carriers of the FTO SNP ranged from 0.2 to 1.1 [23][24][25]39]. Therefore, we assumed a low effect size of 0.5 and a moderate effect size of 1 to conduct the power analysis.…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, few studies have assessed the association of the CLOCK gene with obesity in the pediatric population. Giovaninni et al (n = 340) [ 23 ] and Valladares et al (n = 256) [ 24 ] both assessed the relationship of rs1801260 with BMI in school-age children. Although the association did not reach statistical significance, children who carried the minor allele had a higher rate of overweight and/or BMI z-scores in their studies.…”

Section: Discussionmentioning

confidence: 99%

“…The minor allele of rs1801260 was related to the expression level of the CLOCK gene and consequently might affect the CLOCK-related obesogenic mechanism. Studies have shown that the minor allele of this SNP was associated with lower adiponectin concentration, shorter sleep duration, higher plasma ghrelin concentrations, higher saturated fat intake, and lower response to satiety [10,16,17,24]. Therefore, further research is warranted to clarify the effect of the CLOCK SNP, rs1801260, and examine the relationship between sex and the CLOCK gene particularly in the pediatric population.…”

Section: Plos Onementioning

confidence: 99%

“…Since the CLOCK SNP, rs1801260, might be associated with BMI and weight loss intervention in adults, it potentially had similar effect in children. Giovaninni et al [ 23 ] and Valladares et al [ 24 ] assessed this SNP in school-age children, but the difference in BMI between minor allele carriers and non-carriers did not reach statistical significance.…”

Section: Introductionmentioning

confidence: 99%

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Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

2020

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Disruption of circadian rhythms and variations in the FTO gene may interfere with energy homeostasis and play a role in the development of obesity. The current study assessed the association of common polymorphisms in the CLOCK and FTO genes with standardized body mass index scores (BMI z-scores) and their potential modification of the impact of a culinary nutrition and physical activity intervention in school-age children. Anthropometric measurements were collected in 121 children at the baseline and one-year follow-up of a controlled trial of a school-based culinary nutrition and physical activity intervention. Genotypes of the CLOCK polymorphism (rs1801260) and the FTO polymorphism (rs9939609) were obtained from buccal swabs. Linear mixed-effects regression was applied to evaluate the genetic association and adjust for clusters within families and schools. In our participants, obesity affected 6.6% (8/121) of the children at the baseline and 6.4% (7/109) of the children at the follow-up. The associations between the age-and sex-adjusted BMI z-scores and the two polymorphisms did not reach statistically significance. Yet, sex potentially modified the association between rs1801260 and BMI z-scores. In girls, the G allele carriers had a higher BMI z-scores at the baseline and the follow-up. These polymorphisms did not modify the effect of our culinary nutrition and physical activity intervention on BMI z-scores. Sex is a potential modifier for the association between the CLOCK polymorphism, rs1801260, and BMI z-scores in school-age children. Further investigation is warranted to delineate the sex-dependent role of the CLOCK polymorphisms in the development of childhood obesity.

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Section: Plos Onesupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

2020

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The association among circadian rhythm, circadian genes and chrononutrition, its effect on obesity: a review of current evidence

Uyar

Yıldıran

2022

Biological Rhythm Research

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Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents

Özata Uyar,

Yıldıran,

Teker-Düztaş

et al. 2024

Front. Public Health

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IntroductionCircadian Locomotor Output Cycles Kaput (CLOCK) is one of the transcription factors from the positive end of the molecular clock and regulates biological rhythm in mammals. Studies have shown that genetic variations in the CLOCK genes are associated with chronotype, sleep patterns, obesity, dietary energy, and nutrient consumption. Although interest in the field of chrononutrition continues to increase, investigations into the temporal aspects of dietary habits in adolescents are notably limited. This study aims to investigate the relationship between CLOCK rs3749474, rs4580704, and rs1801260 polymorphisms and circadian rhythm, metabolic parameters along with chrononutrition in adolescents.Materials and methodsThis cross-sectional study included a total of 300 adolescents between the ages of 11 and 18. Anthropometric measurements, dietary intake, chrononutrition, circadian as well as biochemical and lifestyle data were collected. CLOCK rs3749474, rs4580704, and rs1801260 gene polymorphisms were analyzed.ResultsThe CLOCK rs3749474 minor T allele carriers showed a statistically significant increased risk of being overweight or obese (OR: 2.106, p = 0.003). The minor G allele carriers of the CLOCK rs4580704 indicated statistically increased dietary energy intake and eating jetlag (p < 0.05). The frequency of snacking after the last meal was positively correlated with body mass index (BMI) z-scores in minor allele carriers of the CLOCK rs3749474 (β = 0.134, p = 0.003) and rs4580704 (β = 0.142, p = 0.012) variants. The minor G allele carriers of CLOCK rs4580704 revealed a negative link between breakfast frequency along with BMI z-scores (β = −0.178, p = 0.009). Individuals with the rs1801260 minor G allele showed a positive link between BMI z score and meal frequency (β = 0.367, p = 0.049). In CLOCK gene variants, minor allele carriers in addition to non-carriers had similar biochemical parameters and distribution of dietary intake at meal (p> 0.05).ConclusionThese results suggest that the impact of some chrononutrition behaviors on BMI z-scores are partially modulated by the variability in the CLOCK gene variants. Chrononutrition may be important in the shift toward “personalized nutrition” based on gene-diet interactions. For this reason, new dietary approaches may be implemented, including the circadian distribution of macronutrients and chrononutrition behaviors according to genotype. However, studies with larger samples in different populations are needed.

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Association of eating behaviour with clock gene polymorphism 3111 T > C in children based on nutritional status

Cited by 3 publications

References 15 publications

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

Sex modifies the association between the CLOCK variant rs1801260 and BMI in school-age children

The association among circadian rhythm, circadian genes and chrononutrition, its effect on obesity: a review of current evidence

Association between CLOCK gene polymorphisms with circadian rhythm, chrononutrition, dietary intake, and metabolic parameters in adolescents

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