Association of ECG characteristics with clinical and echocardiographic outcome to CRT in a non-LBBB patient population

Dural, Muhammet; Stipdonk, Antonius M.W. van; Salden, Floor C W M; Horst, Iris ter; Crijns, Harry J.G.M.; Meine, Mathias; Maass, Alexander H.; Kloosterman, Mariëlle; Vernooy, Kevin

doi:10.1007/s10840-020-00866-z

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“…In recent studies, the QRS area appears to be a superior marker in the prediction of response to CRT, compared with QRS morphology and duration. 6 , 7 , 28 As QRS area, representing the dispersion of the electrical depolarisation of the ventricles, and T-wave area, representing the dispersion of the repolarisation of the ventricles, represent different phases of the electrical cycle, these measurement might be complementary to each other in their association with outcomes in CRT patients. There are very few studies evaluating the QRS area and T-wave area together in CRT response.…”

Section: Discussionmentioning

confidence: 99%

Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy

Dural,

Ghossein,

Gerrits

et al. 2023

Europace

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Background and Aims Data on repolarization parameters in CRT is scarce. We investigated the association of baseline T-wave area, with both clinical and echocardiographic outcomes of CRT in a large, multi-center cohort of CRT recipients. Also, we evaluated the association between baseline T-wave area and QRS area. Methods In this retrospective study, 1.355 consecutive CRT recipients were evaluated. Pre-implantation T-wave and QRS area were calculated from vectorcardiograms. Echocardiographic response was defined as a reduction of ≥15% in left ventricular end-systolic volume (LVESV) between 3 to 12 months after implantation. The clinical outcome was a combination of all-cause mortality, heart transplantation, and left ventricular assist device implantation. Results LVESV reduction was largest in patients with QRS area ≥109μVs and T-wave area ≥66μVs compared to QRS area ≥109μVs and T-wave area <66μVs (p = 0.004), QRS area <109 μVs and T-wave area ≥66μVs (p < 0.001) and QRS area <109 μVs and T-wave area <66μVs (p < 0.001). Event-free survival rate was higher in the subgroup of patients with QRS area ≥109μVs and T-wave area ≥66μVs (n:616, p < 0.001) and QRS area ≥109μVs and T-wave area <66μVs (n:100, p < 0.001) than the other subgroups. In the multivariate analysis, T-wave area remained associated with echocardiographic response (p = 0.008), but not with the clinical outcome (p = 0.143), when QRS area was included in the model. Conclusions Baseline T-wave area has a significant association with both clinical and echocardiographic outcomes after CRT. The association of T-wave area with echocardiographic response is independent from QRS area, the association with clinical outcome, however is not.

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Section: Discussionmentioning

confidence: 99%

Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy

Dural,

Ghossein,

Gerrits

et al. 2023

Europace

Self Cite

View full text Add to dashboard Cite

show abstract

Association of ECG characteristics with clinical and echocardiographic outcome to CRT in a non-LBBB patient population

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Cited by 1 publication

References 35 publications

Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy

Association of vectorcardiographic T-wave area with clinical and echocardiographic outcomes in cardiac resynchronization therapy

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