Association of efferent neurons to the compartmental architecture of the superior colliculus.

Illing, Robert‐Benjamin

doi:10.1073/pnas.89.22.10900

Cited by 37 publications

(25 citation statements)

References 32 publications

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“…Spatial relationship of somatosensory afferents with tectospinal cells Illing (1992) found that the somas and proximal dendrites of predorsal bundle cells (of which tectospinal cells are one component) lie within the sensory domain (AChEfree) of the rat and suggested that the sensory input to the somas of these neurons might override more distal motor related inputs. Our light microscopic findings contrast with Illing's (1992) data, because the silver grains associated with the trigeminal axons/terminals are apposed to the distal dendrites of the tectospinal neurons.…”

Section: Distribution Of Trigemino-and Corticotectal Axons/terminals mentioning

confidence: 98%

“…Neuroanatomical studies have revealed a ''patchy'' or periodic organization of many of these inputs within the expansive intermediate gray layer, the stratum griseum intermediale (SGI). It has been hypothesized that functionally related afferents commingle within either ''sensory'' or ''motor'' domains of the SGI (Illing andGraybiel, 1985, 1986;Harting and Van Lieshout, 1991;Harting et al, 1992) and that these domains are related to the cells of origin of particular efferent channels (Illing, 1992).…”

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confidence: 99%

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Cortical somatosensory and trigeminal inputs to the cat superior colliculus: Light and electron microscopic analyses

1997

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Two different axonal transport tracers were used in single animals to test the hypothesis that the expansive intermediate gray layer of the cat superior colliculus (stratum griseum intermediale, SGI) is composed of sensorimotor domains. The results show that two sensory pathways, the trigeminotectal and the corticotectal arising from the fourth somatosensory area, commingle in patches across the middle tier of the SGI. Furthermore, the data reveal that tectospinal cells are distributed within these patches. Taken together, these results show a commingling of functionally related afferents and a consistent spatial relationship between these afferents and tectospinal neurons. These relationships indicate that the SGI consists of domains that can be distinguished by their unique combinations of afferent and efferent connections. The ultrastructural characteristics and synaptic relationships of these somatosensory afferent pathways suggest that they have distinct roles within the sensorimotor domain of the SGI. The trigeminotectal terminals are relatively small, contain round vesicles and make asymmetrical synapses on small, presumably distal, dendrites. We submit that these trigeminal terminals bestow the basic receptive field properties upon SGI neurons. In contrast, the somatosensory corticotectal terminals are relatively large, contain round vesicles, make asymmetrical synapses, participate in triads, and are presynaptic to proximal dendrites. We suggest that these cortical terminals bestow integrative abilities on SGI neurons.

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Section: Distribution Of Trigemino-and Corticotectal Axons/terminals mentioning

confidence: 98%

mentioning

confidence: 99%

Cortical somatosensory and trigeminal inputs to the cat superior colliculus: Light and electron microscopic analyses

1997

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“…Celio's (1990) survey included only a brief description of their distributions. Illing et al (1990) described the distribution of PV in rat SC, and Illing (1992) also reported that PV expression correlated with the compartmental architecture of the intermediate SC layers. Schmidt-Kastner et al (1992) made a cursory examination of PV and CB staining patterns in the rat SC during their study of the effects of SC deafferentation, and Lane et al (1993) described a population of CB-immunoreactive cells in the optic layer of the rat SC.…”

mentioning

confidence: 95%

“…In addition to being markers for separate pathways in the SC, the CaBPs are also markers of the compartmental architecture of the intermediate gray layer (IGL). PV is one of the biochemical markers of the matrix surrounding some of the IGL compartments (Illing, 1992).…”

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confidence: 99%

CalbindinD28k- and parvalbumin-immunoreactive neurons form complementary sublaminae in the rat superior colliculus

1998

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By using light microscopic immunocytochemistry and computer analysis, we have mapped the distributions of two calcium-binding proteins (CaBPs), calbindinD28k (CB) and parvalbumin (PV), in the rat superior colliculus (SC). The patterns of CaBP expression were complementary. A band of heavily labeled, medium-sized CB-immunoreactive cells (CB-cells) was centered in the optic layer (OL), whereas PV-immunoreactive cells (PV-cells) were found predominantly in the intermediate gray layer (IGL), where they were clustered within patches of PV-labeled fibers. The superficial gray layer (SGL) could be divided into two sublaminae. CB-cells were found mostly in the dorsal half of the SGL, whereas PV-cells were scattered throughout the ventral SGL and the dorsal OL. Most of the CaBP-immunoreactive cells in the SGL were small bipolar cells with vertically oriented dendrites; however, there were also some PV-cells with horizontally oriented dendrites. Quantitative analysis of the CaBP distributions reinforced our observations that these cells are distributed in complementary tiers that are not restricted to the traditional laminae. The size and shape of some of these tiers were determined from a three-dimensional reconstruction of serial sections. The complementarity of the CaBP-immunoreactive tiers was also confirmed by fluorescence microscopy of double-labeled sections, in which few if any double-labeled neurons were observed. Complementary tiers of CB-cells and PV-cells have been observed previously in the SC of the cat. The present results demonstrate them in another species and further suggest that there are functional sublaminae in the SC that can be distinguished by CaBP content.

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“…This compartmentalization is also apparent through the patchy-like expression of several other neurotransmitters, peptides and enzymes. [44][45][46][47] Visual cortex. Dyn I is mainly expressed in pyramidal neurons of the primary visual areas 17 and 18.…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of Dynamin I Protein in Projection Neurons of the Visual System of the Adult Cat

Cnops

Cuyvers

et al. 2009

J Exp Neurosci

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Abstract:We here report on the immunolocalization of Dynamin I (Dyn I) in neurons of the visual system of the cat. The lateral geniculate nucleus (LGN) complex displayed abundant Dyn I immunoreactivity in typical relay cells of the X-, Y-and W-pathway. The superficial and deep layers of the superior colliculus were also populated by Dyn I-immunoreactive projection neurons of the W-and Y-cell system. In primary visual areas 17 and 18, many densely packed layer VI neurons were intensely stained. A clear Dyn I signal was also demonstrated in pyramidal neurons of supragranular layers II and III, while layer IV displayed low Dyn I immunoreactivity. Additionally, area 18 displayed larger border pyramidal neurons in layer III compared to area 17. Generally, Dyn I was localized to the cell body and dendrites of neurons, to the neuropil and sometimes also to axon bundles. Typically, the Dyn I signal was not always uniformly distributed within the somatodendritic compartment. Based on its widespread distribution mainly in projection neurons Dyn I may play a fundamental role in mature neurons of different cortical and subcortical structures of the adult mammalian brain.

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Association of efferent neurons to the compartmental architecture of the superior colliculus.

Cited by 37 publications

References 32 publications

Cortical somatosensory and trigeminal inputs to the cat superior colliculus: Light and electron microscopic analyses

Cortical somatosensory and trigeminal inputs to the cat superior colliculus: Light and electron microscopic analyses

CalbindinD28k- and parvalbumin-immunoreactive neurons form complementary sublaminae in the rat superior colliculus

Immunolocalization of Dynamin I Protein in Projection Neurons of the Visual System of the Adult Cat

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