2014
DOI: 10.2478/s11536-013-0300-4
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Association of EGF and p53 gene polymorphisms and colorectal cancer risk in the Slovak population

Abstract: AbstractDuring the transformation process single nucleotide polymorphisms (SNPs) of key genes, such as p53 Arg72Pro or EGF A61G, may mediate various cellular processes. These variants may be associated with colorectal cancer risk (CRC), but conflicting findings have been reported. The purpose of this study was to determine the association of the SNPs in 5′ UTR of EGF A61G and p53 Arg72Pro and CRC in the Slovak population. The present case-control study was carried out in 173 co… Show more

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Cited by 7 publications
(10 citation statements)
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“…Distributions of TP53 Arg72Pro genotypes in our control group are almost identical to those reported for the European white, comparable in ethnicity and latitude (24,55,56). We found a preferential loss of the 72Pro allele in MDD patients.…”
Section: Discussionsupporting
confidence: 83%
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“…Distributions of TP53 Arg72Pro genotypes in our control group are almost identical to those reported for the European white, comparable in ethnicity and latitude (24,55,56). We found a preferential loss of the 72Pro allele in MDD patients.…”
Section: Discussionsupporting
confidence: 83%
“…According to the study of Tian et al (27) (n = 463 patients) among a Chinese population, the EGF levels in plasma were significantly lower in the patients with MDD than in the control group (p < 0.001) showing EGF as a possible biomarker for the early diagnosis, treatment and prognosis of MDD. EGF promoter polymorphisms were previously observed to modulate EGF levels and thought to have effect on susceptibility to various carcinomas but the results are contradictory (24). Thus, it will be compulsive to investigate effect of EGF A61G polymorphism on modulating EGF level in MDD patients.…”
Section: Discussionmentioning
confidence: 99%
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“…We have performed a literature search in PubMed focused on population studies of CRC and LS in Slovakia from 2010-2020 using next-generation sequencing. In the Slovak population, only a few population studies of risk variants have been conducted to elucidate the etiology of CRC (Kašubová et al 2019;Mahmood et al 2014;Skerenova et al 2017). In general, little is known about risk variants associated with CRC or LS in the Slovak population.…”
Section: Discussionmentioning
confidence: 99%