1983
DOI: 10.1128/iai.39.3.1243-1251.1983
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Association of elevated levels of cellular lipoteichoic acids of group B streptococci with human neonatal disease

Abstract: Cell-associated lipoteichoic acids (LTAs) from late-exponential-phase cultures (serotypes Ia, Ib, Ic, II, and III) of group B streptococci isolated from infected and asymptomatically colonized infants were quantitated and characterized by growing the organisms in a chemically defined medium containing [3H]glycerol and [14Clacetate. Cell pellets were extracted with 45% aqueous phenol and chloroform-methanol and subjected to DEAE-Sephacel anion-exchange chromatography. Elution profiles resolved three major peaks… Show more

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Cited by 42 publications
(38 citation statements)
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“…In the present experiments, L-arginine potentiated the reduced vascular reactivity to NA in pulmonary arteries of NOS in macrophages (Cunha et al, 1993). Clinical isolates of ** GSB, including type III, recovered from infants with sepsis, possessed significantly higher levels of LTA in their cell wall ** | than those isolated from asymptomatic carriers (Nealon & Mattingly, 1983). The molecular analysis of GBS LTA demonstrated a close similarity with the Group A Streptococcus LTA (Maurer & Mattingly, 1991).…”
Section: Discussionmentioning
confidence: 92%
“…In the present experiments, L-arginine potentiated the reduced vascular reactivity to NA in pulmonary arteries of NOS in macrophages (Cunha et al, 1993). Clinical isolates of ** GSB, including type III, recovered from infants with sepsis, possessed significantly higher levels of LTA in their cell wall ** | than those isolated from asymptomatic carriers (Nealon & Mattingly, 1983). The molecular analysis of GBS LTA demonstrated a close similarity with the Group A Streptococcus LTA (Maurer & Mattingly, 1991).…”
Section: Discussionmentioning
confidence: 92%
“…Whole-cell analysis of LTA and dLTA in GAS and GBS. _o Isolation and purification of LTA and dLTA from whole cells of GBS were first performed by DEAE-Sephacel anion-_~exchange chromatography as previously described (9). This 60 procedure resulted in the separation of two major peaks 7_ containing glycerol and phosphate at a 1:1 molar ratio (9,11).…”
Section: Resultsmentioning
confidence: 99%
“…GBS serotype III strain 110 was isolated from the cerebral spinal fluid of a newborn infant with meningitis * Corresponding author. and has been described previously (9). GAS 147 was isolated from a patient with GAS pharyngitis and was provided by Medical Center Hospital, San Antonio, Tex.…”
mentioning
confidence: 99%
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