Association of Elevated Umbilical Cord Blood Creatine Kinase and Myoglobin Levels with the Presence of Cocaine Metabolites in Maternal Urine

Roby, Paul V.; Glenn, Consuelo M.; Watkins, Sandra L.; Baxter, Louise M.; Kenny, Margaret A.; Nazar-Stewart, Valle; Mayock, Dennis E.

doi:10.1055/s-2007-994427

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Several studies demonstrated remarkable changes in CK activity during labour and its association with the type of delivery. Pharmacological agents such as cocaine, ethanol and halothane are other factors responsible for increased CK activity (13,14). Brain damage, low birth weight, term of delivery and skeletal injuries during delivery could be related to higher CK activity in cord blood (15,16).…”

Section: Introductionmentioning

confidence: 99%

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Khan¹,

Rathore²

2017

EJMR

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Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK-MM. In some conditions like acute myocardial infarction and Neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc.Several reports indicate elevated activity of serum CK in the maternal blood during child birth.

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Section: Introductionmentioning

confidence: 99%

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Khan¹,

Rathore²

2017

EJMR

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show abstract

“…It has been shown that maternal and cord blood CK activity are higher in cesarean as compared to normal delivery [10][11][12] . Pharmacological agents such as cocaine, ethanol and halothane are other factors responsible for increased CK activity [13]. Brain damage, low birth weight, term of delivery and skeletal injuries during delivery could be related to higher CK activity in cord blood [14] .…”

Section: Introductionmentioning

confidence: 99%

Association of cord blood total creatine kinase activity with mode of delivery and APGAR score

Khan¹,

Rathore²,

Singh³

et al. 2017

J. Med. Res.

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Background: Creatine kinase (CK), an enzyme with an important role in consumption and saving energy, especially in muscle tissue. Increased CK is predominantly used to diagnose acute myocardial infarction, Neuromuscular disorders including myopathies, muscular dystrophy, rhabdomyolysis, drug-induced myopathies etc. During child birth, several fold changes in maternal total serum CK activity is observed. Objective: Our study aimed to correlate total CK activity with mode of delivery and APGAR score in newborns. Methods: This was an eighteen months hospital based descriptive study conducted by using a structured data collecting tool. The data were analyzed using SPSS software. Results: Out of 100 newborns, 51 were delivered by full term normal vaginal delivery (FTND) and 49 by lower segment cesarean section (LSCS). Maximum mothers were in the age group of 21 to 30 years. Birth weight of most of the newborns ranged between 2.5-3.0 kgs. We observed elevated total CK activity in both the modes of delivery. Significantly higher total CK activity (p<0.001) was observed in LSCS cases as compared to FTND cases. With decreasing APGAR score, a significant increase (p<0.001) in total CK activity was observed at both 1min and 5 min. Conclusion: Our study revealed that LSCS mode of delivery and lower APGAR scores are associated with increased CK activity..

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“…[5][6][7] Pharmacological agents such as cocaine, ethanol and halothane are other factors responsible for increased CK activity. 8,9 Creatine kinase and its isoenzyme activity show a great variation during pregnancy and labour. 10,11 Fetal distress, brain damage, low birth weight, preterm deliveries and skeletal muscle injury during delivery could be related to higher CK activity in cord blood.…”

mentioning

confidence: 99%

Association of creatine kinase and its isoenzymes (CK-MB, CK-BB) activity with high risk pregnancy

et al. 2017

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Background: Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK- MM. In some conditions like acute myocardial infarction and neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc. Several reports indicate elevated activity of serum CK in the maternal blood during child birth. This study aimed to correlate total CK and its isoenzymes activity in the cord blood with high risk pregnancies.Methods: This was a Prospective observational study conducted in the Obstetrics and Biochemistry Department of Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India. Cord blood of 100 full term newborns was collected and serum was analyzed for total CK and its isoenzymes activity by modified IFCC method. SPSS software was used in data analysis.Results: CK-total and its isoenzymes (CK-MB, CK-BB) activities were observed higher in cases with risk as compared to those without risk. Total CK activity was observed independent while CK-MB and CK-BB were found dependent on different risk factors like pregnancy induced hypertension and fetal distress etc.Conclusions: Present study revealed that high risk pregnancies are associated with increased total CK, CK-MB as well as CK-BB activity.

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Association of Elevated Umbilical Cord Blood Creatine Kinase and Myoglobin Levels with the Presence of Cocaine Metabolites in Maternal Urine

Cited by 6 publications

References 8 publications

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Association of cord blood total creatine kinase activity with mode of delivery and APGAR score

Association of creatine kinase and its isoenzymes (CK-MB, CK-BB) activity with high risk pregnancy

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