2023
DOI: 10.21705/mcbs.v7i1.297
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Association of ELMO1 Genetic Polymorphism (rs741301) with the Progression of Diabetic Kidney Disease in Balinese Patients with Type 2 Diabetes Mellitus

Abstract: Background: Diabetic kidney disease (DKD) is one of diabetes mellitus microvascular complications. Engulfment and cell motility 1 (ELMO1) protein interacts with dedicator of cytokinesis 180 (DOCK180) and cyclooxygenase (COX)-2, which affects gene expression in extracellular matrix (ECM) and causes glomerular damage in several mechanisms, such as ECM accumulation and renal tubules thickening. Single nucleotide polymorphism (SNP) rs741301 is one of the ELMO1 genetic polymorphisms involved in DKD. The aim of this… Show more

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“…In addition, hypertension is defined as having a systolic blood pressure of at least 140 and/or a diastolic blood pressure of at least 90 millimeters of mercury (Kemenkes RI, 2020). Hypertension can increase the risk of heart, brain, kidney, and other diseases (Kirtaniya et al, 2023;Santosa et al, 2022). According to data from WHO in 2021, more than one billion world population has hypertension, which is one of the leading causes of premature death in 1 in 4 men and 1 in 5 women (WHO, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…In addition, hypertension is defined as having a systolic blood pressure of at least 140 and/or a diastolic blood pressure of at least 90 millimeters of mercury (Kemenkes RI, 2020). Hypertension can increase the risk of heart, brain, kidney, and other diseases (Kirtaniya et al, 2023;Santosa et al, 2022). According to data from WHO in 2021, more than one billion world population has hypertension, which is one of the leading causes of premature death in 1 in 4 men and 1 in 5 women (WHO, 2022).…”
Section: Introductionmentioning
confidence: 99%