Association of Endothelial Nitric Oxide Synthase Promoter Region (T-786c) Gene Polymorphism With Acute Coronary Syndrome and Coronary Heart Disease

Çıftçı, Çavlan; Melil, Süreyya; Çebi, Y; Ersöz, Melike; Çağatay, Penbe; Kılıçgedik, M; Duman, Belgin Süsleyici

doi:10.1016/s1567-5688(08)70410-0

Cited by 3 publications

(4 citation statements)

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“…Granath et al found no signifi-cant difference between patients and controls regarding frequency of CC (mutant) genotype [15]. Additionally, Ciftçi et al showed that the high frequency of TT (wild type) genotype in the patients may support no relationship of T786C polymorphism with premature MI [6].…”

Section: Discussionmentioning

confidence: 99%

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eNOS Gene Variants and the Risk of Premature Myocardial Infarction

et al. 2013

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BACKGROUND: Endothelial nitric oxide synthase (eNOS) as well as nitric oxide play an important role in the regulation of cardiovascular function. There are limited and controversial data regarding the impact of polymorphisms of eNOS gene that is implicated in the vasoconstrictive properties of the endothelium in the pathogenesis of premature myocardial infarction (MI).OBJECTIVE: We examined whether two common polymorphisms of eNOS gene (G894T and T786C) are associated with the development of premature MI.METHODS: We recruited 107 patients with premature MI and compared them to 103 age- and sex- matched controls. All patients underwent coronary angiogram and were classified into the subgroup of patients with ‘normal’ or ‘near normal’ coronary arteries and the subgroup of patients with significant coronary artery disease (≥ 50% stenosis in lumen diameter of coronary arteries). The genetic polymorphisms of eNOS gene were assayed with polymerase chain reaction and reverse hybridization.RESULTS: Nineteen patients (17.8%) had ‘normal’ or ‘near normal’ coronary arteries. A significantly higher frequency of homozygosity for the 786C (32%) and the 894T (21%) alleles of the eNOS gene in patients who develop early MI in the setting of angiographically 'normal' or 'near normal' coronary arteries were found.CONCLUSIONS: Our data suggest that the T786C and the G894T genetic polymorphisms are associated with the development of MI in very young individuals, whose coronary arteries are characterized by very small atheromatic burden.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that these polymorphisms are associated with reduced eNO generation [7,9,13]. Furthermore, they may be implicated in the development of premature myocardial infarction (MI), although their actual role has been questioned by several studies [1,2,6,15,19,25].…”

Section: Introductionmentioning

confidence: 99%

eNOS Gene Variants and the Risk of Premature Myocardial Infarction

et al. 2013

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“…У наших больных частота NOS3 -786TT генотипа более чем в 2 раза снижена в группе с высоким риском развития ССО. Предполагается, что наличие минорного аллельного варианта гена приводит к уменьшению транскрипционной активности последнего, снижению содержания NO в коронарных артериях и предрасполагает пациентов -носителей минорного аллеля к спазму сосудов и развитию острых коронарных событий [12], однако требуется дальнейшее изучение связи уровня продукции NO с полиморфизмом гена NOS3.…”

Section: Discussionunclassified

Gene Polymorphisms of Endothelial Dysfunction, Coactivators of Mitochondrial Biogenesis and Plasminogen/Plasmin System in the Development of Cardiovascular Events in Rheumatoid Arthritis

Shevchenko¹,

Прокофьев²,

Королев³

et al. 2018

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“…They concluded that the À786 T/C mutation had a strong association with myocardial infarction, especially without coronary arterial stenosis, in Japanese patients. Ciftci et al (2008) also reported that À786 T/C (rs2070744) and 894 G/T (rs1799983) were associated with low plasma NO concentrations and reduced vascular reactivity, and their importance in the onset of CHD has been emphasized (Casas et al, 2006). Considering these findings, the relations between eNOS gene polymorphism and ACS and coronary artery disease were varied and have been controversial.…”

Section: Discussionmentioning

confidence: 99%