Association of erythrocyte sedimentation rate and C-reactive protein and clinical findings with HLA-DQ8 allele in Rheumatoid Arthritis patients

Abstract

Background-Rheumatoid arthritis (RA) is an inflammatory, autoimmune disease induced by certain auto-antigens. HLA-DRB1*0401 allele has a significant relationship with RA incident. Additionally, DQβ1*0301, *302(DQ8), *303, and *304 can increase RA risk especially in DQA1*0301 and *302 coincident. Recent studies suggest that distribution of this allele is different in various populations Material and Methods-70 patients and 70 healthy controls were analyzed for human leukocyte antigen (HLA) allele by specific primerpolymerase chain reaction (SSP-PCR) method. Patients were evaluated in terms of ESR and CRP. Data analysis was performed in SPSS V.17. Results-HLA-DQ8 allele was significantly more frequent in RA patients compared to control (P<0.0001). However, no significant relationship was observed between increased ESR (P=0.527), CRP (P=0.505), and mean counts of arthritic (P=0.691) and tender joints (P=0.669) among the patients who were carriers of HLA-DQ8. Conclusion-There is a significant association between RA and HLA-DQ8 allele, this allele can increase susceptibility to RA. These findings might relate to the ethnical variations of RA patients but we couldn't find a significant association between CRP and ESR with HLA-DQ8. We recommend to add specific inflammatory markers to CRP as well as assess ESR in larger sample sizes to obtain accurate results.

TNF-α -308 G>A and IL10 -1082A>G polymorphisms as potential risk factors for lymphoproliferative disorders in autoimmune rheumatic diseases

“…Dysregulated immune stimulation and chronic inflammation are the most noteworthy studied risk for lymphomagenesis in ARD patients. Information on the disease characteristics along with the general reviewing of the systems in ARD patients can unveil the development of some worrisome signs that raise the suspicion of LPD development, e.g., high ESR values, erosive joint diseases, lymph node enlargement, organomegaly, night sweating, fever, and weight loss may alarm the development of malignancy [15][16][17]. It is suggested that pathogenesis of ARD that resulted from chronic B cell activation and inflammation are risk determinants of malignant transformation of B cells and lymphoma development.…”