Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET/CT Perspective

Wu, Yen-Wen; Tseng, Ping‐Huei; Lee, Yi–Chia; Wang, Shan-Ying; Chiu, Han–Mo; Tu, Chia‐Hung; Wang, Hsiu-Po; Lin, Jaw–Town; Wu, Ming–Shiang; Yang, Wei‐Shiung

doi:10.1371/journal.pone.0092001

Cited by 27 publications

(19 citation statements)

References 39 publications

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“…5). The SUV parameters presented in previous studies suggested the possibility of FDG PET/CT to detect GERD or esophagitis [26,27], which was also observed in our study. On the other hand, Barrett's esophagus is a consequence of gastroesophageal reflux disease.…”

Section: Discussionsupporting

confidence: 89%

A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy

Kim

Cha

et al. 2015

Nucl Med Mol Imaging

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Purpose The aim of this study was to compare the esophageal findings of 2-deoxy-2-[ F-FDG uptake were visually analyzed. The maximum standardized uptake value (SUV max ) of the esophagus and around the esophagogastric (EG) junction was measured. EGD results were provided by the gastroenterologist. We compared the esophageal findings obtained using F-FDG uptake in the esophagus. Reflux esophagitis was diagnosed in 59 subjects, and 27 of these were classified as higher than Los Angeles classification A. With an increasing degree of reflux esophagitis observed on EGD, the SUV max in the esophagus and around the EG junction was also increased. Conclusion Our study showed that FDG uptake at the esophagus or the EG junction might be clinically significantly related to esophagitis. However, EGD performed before

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Section: Discussionsupporting

confidence: 89%

A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy

Kim

Cha

et al. 2015

Nucl Med Mol Imaging

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“…94 The prevalence of GERD in individuals with morbid obesity is as high as 45%, with obesity increasing the risk of GERD becoming symptomatic, erosive oesophagitis and oesophageal adenocarcinoma. 95 Markers of visceral and general obesity are independent determinants of oesophageal inflammation, which correlates with endoscopic findings and symptoms of GERD. Bariatric procedures improve GERD-the greater the excess weight loss (EWL), the greater the improvement in GERD score.…”

Section: Weight-loss-dependent Effectsmentioning

confidence: 99%

Bariatric and metabolic surgery: a shift in eligibility and success criteria

2015

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The obesity epidemic, combined with the lack of available and effective treatments for morbid obesity, is a scientific and public health priority. Worldwide, bariatric and metabolic surgeries are increasingly being performed to effectively aid weight loss in patients with severe obesity, as well as because of the favourable metabolic effects of the procedures. The positive effects of bariatric surgery, especially with respect to improvements in type 2 diabetes mellitus, have expanded the eligibility criteria for metabolic surgery to patients with diabetes mellitus and a BMI of 30-35 kg/m(2). However, the limitations of BMI, both in the diagnosis and follow-up of patients, need to be considered, particularly for determining the actual adiposity and fat distribution of the patients following weight loss. Understanding the characteristics shared by bariatric and metabolic surgeries, as well as their differential aspects and outcomes, is required to enhance patient benefits and operative achievements. For a holistic approach that focuses on the multifactorial effects of bariatric and metabolic surgery to be possible, a paradigm shift that goes beyond the pure semantics is needed. Such a shift could lead to profound clinical implications for eligibility criteria and the definition of success of the surgical approach.

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“…In spite of recent advances in continuous imaging with 320 row area detector CT scan as described by Fukazawa et al [18], and positron emission tomography/computed tomography (PET/CT) as reported by Wu et al [19] for gastrointestinal disorders, these imaging modalities are not standard of care for diagnosis of GERD, so detection of ED on chest CT scan or high-resolution chest CT scan (HRCT ) is an incidental and challenging finding. Firstly, esophageal stasis may predis- …”

Section: Discussionmentioning

confidence: 99%

Association of esophageal dilatation in chest CT scan with gastroesophageal reflux disease: A case control study

Hashemi

Moosavi²,

Idani³

et al. 2018

Monaldi Arch Chest Dis

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The presence of increased air bubble in the lumina of esophagus on a chest CT scan may be associated with esophageal disorders. The purpose of this study was to determine the association between the appearance of air bubbles on chest CT scan and gastroesophageal Reflux Disease (GERD). In this case-control study, thirty-two patients with endoscopically proved GERD and 32 subjects without GERD underwent chest computed tomography (CT) scanning. Esophageal dilatation (ED) was defined as the presence of air bubbles greater than 10 mm in the supra ventricle (SV) and ventricle (CV), and air bubbles >15 mm in the ventricle to the lower esophageal sphincter (V-LES). The results were compared between the two groups. The GERD patients included 16 (50%) males with a mean age of 58.5±11.2 years and the control group included 17 (54.8%) males and 14 (45.1%) females with a mean age of 66.7±10.5 years. There was a significant relationship between the presence of GERD and esophageal dilation (ED) in the V-LES sections on the CT scan (P=0.002). The mean size of the air bubbles in the V-LES section was 11.73 mm in the case group in comparison to 4.32 mm in the control group (P<0.001). The size and location of the air bubbles in the esophagus can vary and be important. The possibility of GERD increases in the presence of esophageal dilation on CT scan.

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Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET/CT Perspective

Cited by 27 publications

References 39 publications

A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy

A Comparison Study of Esophageal Findings on 18F-FDG PET/CT and Esophagogastroduodenoscopy

Bariatric and metabolic surgery: a shift in eligibility and success criteria

Association of esophageal dilatation in chest CT scan with gastroesophageal reflux disease: A case control study

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