Association of estimated glomerular filtration rate and incident pre-diabetes: A secondary 5-year longitudinal cohort study in Chinese people

Wang, Xiaoyu; Huang, Cheng; Liu, Yuanyuan; Han, Yong; Hu, Haofei

doi:10.3389/fendo.2022.965545

Cited by 5 publications

(4 citation statements)

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“…Likewise, a population-based cohort study conducted in Taiwan identified CKD as a crucial and independent predictor of diabetes, with an adjusted HR of 1.204 and a 95% CI of 1.11 to 1.31[ 52 ]. Our previous research also discovered that decreased eGFR was strongly linked to a higher risk of developing both diabetes (HR = 0.986, 95% CI 0.984, 0.988) [ 20 ] and pre-diabetes (HR = 0.993, 95% CI 0.992–0.995) [ 21 ] in the general Chinese population. Given this information, we posited that a diminished eGFR might be linked to a decreased likelihood of returning to normoglycemic levels from a state of IFG.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a Chinese study found that, in healthy individuals, FPG (but not 2-h post-load blood glucose or glycated hemoglobin A1c) was linked to a mild decline in eGFR [ 19 ]. Prior community-based investigations in China have demonstrated an inverse and non-linear correlation between eGFR and the hazards of diabetes and pre-diabetes [ 20 , 21 ]. Nevertheless, extant literature does not provide any indication of a relationship between eGFR (both lower and higher levels) and pre-diabetes regression to normoglycemia.…”

Section: Introductionmentioning

confidence: 99%

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Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

Tu,

Hu,

Zhou

et al. 2024

Eur J Med Res

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Objectives The present body of evidence regarding the correlation between the estimated glomerular filtration rate (eGFR) and the reversal of impaired fasting glucose (IFG) to normoglycemia remains constrained. Consequently, the objective of our study is to examine the relationship between eGFR and the restoration of normoglycemia in individuals with IFG. Methods This retrospective cohort study consecutively collected data from 24,541 non-selective participants with IFG at Rich Healthcare Group in China from January 2010 to 2016. We aimed to investigate the association between baseline eGFR and reversion to normoglycemia using the Cox proportional-hazards regression model. Through the utilization of a Cox proportional hazards regression model featuring cubical spline smoothing, we were able to ascertain the non-linear correlation between eGFR and the return to normoglycemia. Furthermore, various sensitivity and subgroup analyses were carried out, and a competing risk multivariate Cox regression was employed to examine the progression to diabetes as a competing risk for the reversal of normoglycemic events. Results In our study, comprising 24,541 participants, the average age was 49.25 ± 13.77 years, with 66.28% being male. The baseline eGFR mean was 104.16 ± 15.78 ml/min per 1.73 m2. During a median follow-up period of 2.89 years, we observed a reversion rate to normoglycemia of 45.50%. Upon controlling for covariates, our findings indicated a positive correlation between eGFR and the probability of returning to normoglycemia (HR = 1.008, 95% CI 1.006–1.009). In addition, a non-linear association was observed between eGFR and the likelihood of transitioning from IFG to normoglycemia. The inflection point of eGFR was found to be 111.962 ml/min per 1.73 m2, with HRs of 1.003 (95% CI 1.001, 1.005) on the left side of the point and 1.019 (95% CI 1.015, 1.022) on the right side. Our robust results were supported by competing risks multivariate Cox's regression and sensitivity analysis. Conclusions The findings of our investigation indicate a favorable and non-linear correlation between eGFR and the restoration of normoglycemia in Chinese individuals with IFG. Specifically, a reduction in renal function at an early stage in these patients may considerably diminish the likelihood of attaining normoglycemia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

Tu,

Hu,

Zhou

et al. 2024

Eur J Med Res

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“…Smoking status was categorized into three distinct groups according to individuals’ smoking behavior: current smokers, individuals who have smoked in the past, and individuals who have never smoked. Similarly, drinking status was classified into three categories based on individuals’ drinking behavior: current drinkers, individuals who have previously consumed alcohol, and individuals who have never consumed alcohol ( 28 ). Daily activity was defined as engaging in at least 1.25 hours of vigorous activity per week, 2.5 hours of moderate-intensity activity per week, or a combination of both (equivalent to at least 600 metabolic equivalent minutes per week) ( 29 ).…”

Section: Methodsmentioning

confidence: 99%

“…Covariates were selected based on previous research and our clinical knowledge (17,23,27). The following factors were included as covariates: (i) categorical variables: diabetes mellitus (DM), sex, hypertension, chronic lung disease (CLD), smoking status, coronary heart disease (CHD), drinking status, chronic kidney disease(CKD), daily activity, antihypertensive drug use, antihyperglycemic drug use, antihyperlipidemic drug use, malignant tumors, mental disease,; (ii) continuous variables: age, white blood cell (WBC), hs-CRP, HGB, blood urea nitrogen (BUN), PLT, body mass index (BMI), diastolic blood pressure (DBP), TG, systolic blood pressure (SBP), UA, hemoglobin A1c (HbA1c), and serum creatinine (Scr).…”

Section: Covariatesmentioning

confidence: 99%

The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

Wang,

Han,

Cao

et al. 2024

Front. Endocrinol.

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ObjectiveThis study aims to assess the association between the non-HDL-c/HDL-c ratio and stroke risk among middle-aged and older adults participating in the China Health and Retirement Longitudinal Study (CHARLS).MethodsThis study conducted a prospective cohort analysis, enrolling a total of 10,183 participants who met the designated criteria from CHARLS between 2011 and 2012. We then used the Cox proportional-hazards regression model to explore the relationship between baseline non-HDL-c/HDL-c ratio and stroke risk. Using a Cox proportional hazards regression with cubic spline function, we were able to identify the non-linear relationship between the non-HDL-c/HDL-c ratio and stroke occurrence. A series of sensitivity analyses were also carried out.ResultsThe average age of the participants included in this study was 59.16 ± 9.35 years, and 4,735 individuals (46.68%) were male. Over a median follow-up period of 7.0 years, a total of 1,191 people (11.70%) experienced a stroke. Using a Cox proportional hazards regression model that was fully adjusted, we found no statistically significant correlation between the non-HDL-c/HDL-c ratio and the risk of stroke (HR=1.022; 95% CI 0.964, 1.083). Nevertheless, we did observe a non-linear relationship and saturation effect between the non-HDL-c/HDL-c ratio and stroke. Employing a two-piece Cox proportional hazards regression model and a recursive algorithm, we determined an inflection point of 2.685 for the non-HDL-c/HDL-c ratio. In instances where the non-HDL-c/HDL-c ratio fell below 2.685, for every 1-unit decrease in the non-HDL-c/HDL-c ratio, the likelihood of stroke decreased by 21.4% (HR=1.214, 95% CI: 1.039-1.418). In contrast, when the non-HDL-c/HDL-c ratio exceeded 2.685, there was no statistically significant change in the risk of stroke for each unit decrease in the non-HDL-c/HDL-c ratio (HR: 0.967, 95% CI: 0.897-1.042). The consistency of these findings across multiple sensitivity analyses suggests their robustness.ConclusionThis study unveils a non-linear relationship between the non-HDL-c/HDL-c ratio and stroke risk in middle-aged and older adults in China. Specifically, when the non-HDL-c/HDL-c ratio was below 2.685, a significant and clearly positive association with stroke risk was observed. Additionally, maintaining the non-HDL-c/HDL-c ratio below 2.685 could potentially lead to a substantial reduction in the risk of stroke.

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Physical activity modifies the association between atherogenic index of plasma and prediabetes and diabetes: A cross‐sectional analysis

Yang,

Gou,

Dong

et al. 2024

Journal of Diabetes

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BackgroundAlthough research has explored the association between atherogenic index of plasma (AIP) and prediabetes and diabetes, there is still not sufficient available evidence the role of physical activity (PA) in this relationship. Our purpose is to examine the complex connections between AIP, PA, and prediabetes and diabetes in a young and middle‐aged population.MethodsThis study included 2220 individuals from the general population, aged 20–60 years. AIP was calculated from the logarithm of the triglyceride (TG) to high‐density lipoprotein cholesterol (HDL‐C) ratio. PA was assessed depending to the American Heart Association (AHA) criteria and categorized into medium‐high and low PA levels. We used binary logistic regression to explore associations and subsequently performed sensitivity and subgroup analyses.ResultsThe 2220 participants had a mean age of 38 years, with a mean AIP of −0.1185, and a prediabetes and diabetes prevalence of 7.2%. After adjusting for auxiliary variables, AIP was positively correlated with prediabetes and diabetes (odds ratio [OR]: 3.447, 95% confidence interval [CI]: 1.829–6.497). In the low PA population, the prevalence of prediabetes and diabetes raised significantly with higher AIP (OR: 3.678, 95% CI: 1.819–7.434). This association was not meaningful in the medium to high PA population (OR: 1.925, 95% CI: 0.411–9.007). Joint and sensitivity analyze results also showed agreement. Restricted cubic spline identified a linear relationship between AIP and the prevalence of prediabetes and diabetes. Notably, the prevalence significantly increases when AIP values exceed −0.16 (p for linearity <0.05). The findings revealed heterogeneity across subgroups stratified by sex and age.ConclusionsPA may modify the link as regards AIP with prediabetes and diabetes in young and middle‐aged populations. Adherence to PA prevents the adverse effects of abnormal glucose metabolism caused by dyslipidemia, particularly in women.image

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Association of estimated glomerular filtration rate and incident pre-diabetes: A secondary 5-year longitudinal cohort study in Chinese people

Cited by 5 publications

References 55 publications

Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study

The non-linear link between non-high-density lipoprotein to high-density lipoprotein ratio and the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study

Physical activity modifies the association between atherogenic index of plasma and prediabetes and diabetes: A cross‐sectional analysis

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