Association of estrogen receptor α gene polymorphism with the presence of coronary artery disease documented by coronary angiography

Association Between Estrogen Receptor-α PvuII and XbaI Gene Polymorphisms With Extracranial Carotid Stenosis

“…13,14 In a most recent study, the author also did not observe an association between ESR1 PvuII and XbaI gene polymorphisms with the risk of CAD in an Iranian population. 9 Moreover, there are conflicting results about the impact of these polymorphisms on the risk of stroke. 15,16 Intimal-medial thickening (IMT) of the carotid artery is a quantitative measure of atherosclerosis assessed by B-mode ultrasonography.…”

“…We have recently found there is no association between ESR1 PvuII and XbaI gene polymorphisms with coronary artery disease (CAD). 9 The aim of this study was to determine whether ESR1 PvuII and XbaI gene polymorphisms influence carotid artery atherosclerosis in an Iranian sample.…”

Estrogen receptor α gene PvuII polymorphism and coronary artery disease: a meta-analysis of 21 studies

“…1). The study by Boroumand et al (2009) was excluded because CAD was diagnosed by the Gensini score.…”

ESR1 gene polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) may not be directly correlated with cardiovascular disease risk

“…The PvuII restriction site polymorphism is associated with rs2234693 (397T>C), while the XbaI restriction site polymorphism involves rs9340799 (351A>G) (Kunnas et al, 2010). Previous studies examining the contribution of the ESR1 polymorphisms PvuII (rs2234693T>C) and XbaI (rs9340799A>G) revealed that they were strongly correlated with CVD susceptibility (Xu et al, 2008;Boroumand et al, 2009) or that there were links with CVD in different study populations (Xing et al, 2013).In order to address these issues, a meta-analysis was performed based on previous reports to assess the associations between the ESR1 gene PvuII (rs2234693T>C) and XbaI (rs9340799A>G) polymorphisms and the risk of CVD.…”