2021
DOI: 10.3390/genes12081248
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Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer

Abstract: MicroRNA is a class of non-coding RNA involved in post-transcriptional gene regulation. Aberrant expression of miRNAs is well-documented in molecular cancer biology. Extensive research has shown that miR-210 is implicated in the progression of multiple cancers including that of the lung, bladder, colon, and renal cell carcinoma. In recent years, exosomes have been evidenced to facilitate cell–cell communication and signaling through packaging and transporting active biomolecules such as miRNAs and thereby modi… Show more

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Cited by 12 publications
(8 citation statements)
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“…The interaction of miR-210 with the BNIP3 transcript (significantly upregulated in PANF) can protect cancer cells against hypoxic damage [ 49 ]. miR-210 also regulates signalling cascades with the central position of the TIMP1 gene [ 50 ] non-significantly upregulated in PANF. The TIMP1 protein is known as an inhibitor of metalloproteinases participating in the remodelling of the extracellular matrix in tumors [ 51 ].…”
Section: Resultsmentioning
confidence: 99%
“…The interaction of miR-210 with the BNIP3 transcript (significantly upregulated in PANF) can protect cancer cells against hypoxic damage [ 49 ]. miR-210 also regulates signalling cascades with the central position of the TIMP1 gene [ 50 ] non-significantly upregulated in PANF. The TIMP1 protein is known as an inhibitor of metalloproteinases participating in the remodelling of the extracellular matrix in tumors [ 51 ].…”
Section: Resultsmentioning
confidence: 99%
“…In the case of miR‐210, Zimmermann et al [ 42 ] described the overexpression of this miRNA in metastasis vs. primary GEP NENs and in samples with higher proliferative rates. Moreover, its role in angiogenesis is also well‐known: miR‐210 levels increases in hypoxia and induce HIF1A and VEGF expression by inhibiting VEGF's negative regulators or through the JAK/STAT pathway [ 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among them, miRNA-210 (miR-210) is the established goal of hypoxia inducible factor, and its upregulation is the characteristic of hypoxia condition. At present, most studies on the function of miR-210 have focused on its relationship with various cancers, including pancreatic cancer and lung cancer [6,7]. Studies in infertility diseases have found that miR-210 in testicular tissue rises signi cantly in two types of diseases (the spermatocyte stage (MA) and Sertoli cell-only syndrome (SCOS) ), indicating that miR-210 may play a key role in the meiosis stage of spermatocytes and secretion-related functions in Sertoli cells [8].…”
Section: Introductionmentioning
confidence: 99%