Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea

Hong, Jae Young; Han, Kyungdo; Jung, Jae-Hun; Kim, Jung Sun

doi:10.1001/jamanetworkopen.2019.10584

Cited by 129 publications

(85 citation statements)

References 37 publications

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“…When deciding whether to use CT on children, the harmful effects that radiation may have on a growing body must be considered. Hong et al, in a study of 12,068,821 children aged 0 to 19 years, found a statistically significant increase in cancer in children exposed at least once to diagnostic low-dose ionizing radiation after adjusting for age and sex [29,30]. Based on our data, we do not recommend using CT for determining clinical recovery unless it is necessary to evaluate the status of pneumonia.…”

Section: Discussionmentioning

confidence: 55%

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A single-center, retrospective study of COVID-19 features in children: a descriptive investigation

Hui

et al. 2020

BMC Med

125

150

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Background: Compared to adults, there are relatively few studies on COVID-19 infection in children, and even less focusing on the unique features of COVID-19 in children in terms of laboratory findings, locations of computerized tomography (CT) lesions, and the role of CT in evaluating clinical recovery. The objective of this study is to report the results from patients at Wuhan Children's Hospital, located within the initial center of the outbreak.Methods: Clinical, imaging, and laboratory data of 76 children were collected retrospectively and analyzed with the Fisher exact test and Cox regression statistical methods.Results: Among 50 children with a positive COVID-19 real-time reverse-transcriptase polymerase chain reaction (PCR), five had negative PCR results initially but showed positive results in subsequent tests. Eight (16%) patients had lymphopenia, seven (14%) with thrombocytopenia, four (8%) with lymphocytosis, two (4%) with thrombocytosis, ten (20%) with elevated C-reactive protein, four (8%) with hemoglobin above, and six (12%) with below standard reference values. Seven (14%) of the 50 had no radiologic evidence of disease on chest CT. For the 43 patients who had abnormal CT findings, in addition to previously reported patterns of ground-glass opacity (67%), local patchy shadowing (37%), local bilateral patchy shadowing (21%), and lesion location of lower lobes (65%), other CT features include that an overwhelming number of pediatric patients had lesions in the subpleural area (95%) and 22 of the 28 lower lobe lesions were in the posterior segment (78%). Lesions in most of the 15 patients (67%) who received chest CT at discharge were not completely absorbed, and 26% of these pediatric patients had CT lesions that were either unchanged or worse.(Continued on next page)

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Section: Discussionmentioning

confidence: 55%

“…Because of how many unknowns there were about the disease, particularly at the beginning of the COVID-19 outbreak, CT was frequently used in the clinical management and diagnosis of children in China. Notably, repeated use of CT can be harmful, particularly for children [29,30].…”

Section: (Continued From Previous Page)mentioning

confidence: 99%

A single-center, retrospective study of COVID-19 features in children: a descriptive investigation

Hui

et al. 2020

BMC Med

125

150

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“…Typical chest imaging manifestations are reported to include multiple, patchy, sub-segmental or segmental ground glass density shadows in both lungs (1), though atypical findings are increasingly common. However, hereby we hope to reiterate that while CT radiation is associated with nonnegligible oncogenic risk (10,11), till now the role of CT for Covid-19 patients care remains poorly defined. Currently there is no effective anti-viral treatment or vaccine for 2019-nCoV (1).…”

mentioning

confidence: 88%

The role of CT for Covid-19 patient’s management remains poorly defined

Wáng¹,

Liu²,

Yang³

et al. 2020

Ann Transl Med

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“…Similarly, X-rays are typically used to provide static images of body parts (such as teeth and bones), and are also used in industry to find defects in welds. But, ionizing radiations can be potentially harmful if not used correctly as these also include Alpha Particles, Beta Particles, Gamma Rays and X-Rays and Neutrons: which are emitted from naturally occurring radioactive materials (such as uranium, thorium, and radium) and other man-made radioactive elements and thus, need to be handled with utmost care (1)(2)(3)(4)(5)(6)(7)(8) .…”

Section: A Ionizing Radiationmentioning

confidence: 99%

“…Among the human beings, children and fetus are especially prone to radiation. Major sources of radiation exposure to this population group include diagnosis instruments used in hospitals, communication systems, dryers, etc 3,4 . This paper has been aimed to study the adverse effects of electromagnetic radiation on human health, especially mother, fetus and children.…”

Section: Introductionmentioning

confidence: 99%

Harmful Effects of Ionizing Radiation

Guleria¹

2019

IJRASET

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Human population throughout the world is surrounded by an invisible continuously increasing web of radiation, originating from both natural and non-natural sources. Radiation is of two types: ionizing and non-ionizing depending upon their energy. The exposure to radiation has increased many folds in the recent years with the invention and launch of many electromagnetic devices. Exposure to ionizing radiations has been found to cause severe abnormalities in human beings such as DNA damage, cancer, infertility, electro-hypersensitivity, etc. which however is of different intensity depending upon the age group of human beings, with children and fetus being the maximum sufferers because of immature immune system and also various other cells in their body are still at the stage of division and differentiation. Present study has been aimed to investigate a generalized preliminary idea of various health related complications caused by ionizing radiations to human beings with special emphasis to fetus and children.

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Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea

Abstract: This cohort study examines the association of low-dose radiation exposure in youths with risk of cancer using South Korean national health insurance data.

Cited by 129 publications

References 37 publications

A single-center, retrospective study of COVID-19 features in children: a descriptive investigation

A single-center, retrospective study of COVID-19 features in children: a descriptive investigation

The role of CT for Covid-19 patient’s management remains poorly defined

Harmful Effects of Ionizing Radiation

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