Association of exposure to environmental vanadium and manganese with lung function among young children: A population-based study

Fan, Nai-Chia; Huang, Hsin-Yi; Wang, Shih-Ling; Tseng, Yu-Lun; Chang-Chien, Ju; Tsai, Hui-Ju; Yao, Tsung-Chieh

doi:10.1016/j.ecoenv.2023.115430

“…This study used the data collected from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort, including 1513 children who were born in 2010 through 2011 in Chang Gung Memorial Hospital and who attended a follow-up visit at a mean age of 6.4 years, ranging from 5.5 to 7.9 years, as has been described elsewhere [21][22][23][24][25][26][27]. BMI and body fat percentages were measured during the follow-up visit between 2016 and 2018.…”

Section: Study Participantsmentioning

confidence: 99%

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

Hung,

Lee,

Tsai

et al. 2024

Obesity

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ObjectiveThis study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.MethodsIn a population‐based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.ResultsMaternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI z score (β: −0.22; 95% CI: −0.39 to −0.05), whole body fat percentage (β: −1.28; 95% CI: −2.27 to −0.30), trunk fat percentage (β: −1.41; 95% CI: −2.78 to −0.04), and limb fat percentage (β: −1.31; 95% CI: −2.32 to −0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI z score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below‐tertiary educational level.ConclusionsThis study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.

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“…Актуальность регламентирования диванадия пентоксида обусловлена его высокой токсичностью, которая определяется рядом неблагоприятных эффектов, которые могут возникнуть у человека в условиях ингаляционного воздействия. Считается, что в первую очередь пятиоксись ванадия оказывает действие на структуры дыхательной системы [1][2][3][4][5][6][7][8][9][10]. Однако по результатам проведения идентификации опасности в ряде исследований установлено влияние диванадия пентоксида и на другие органы и системы: например, органы зрения 7 [11][12][13][14][15], кожные покровы [11], иммунную систему в виде нарушений гуморального и клеточного компонента иммунитета [6,16,17].…”

Section: актуальность исследования определяется санитарно-эпидемиолог...unclassified

Scientific substantiation of average annual maximum permissible level of vanadium pentoxide in ambient air as per permissible health risk

Chetverkina

2024

Health Risk Analysis

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Relevance of this study is determined by the sanitary-epidemiological legislation of the Russian Federation with stipulated requirements to create hygiene standards for environmental factors ensuring their safety for people. These hygienic standards should guarantee absence of impermissible lifetime health risks. Divanadium pentoxide is a chemical that should be mandatorily regulated in ambient air under long-term exposure due to its wide prevalence and high toxicity. An average annual MPL for divanadium pentoxide was established by using systemic analysis of research literature and regulatory documents. According to selection results, three key epidemiological studies were taken for further analysis. They provided evidence of adverse effects produced by divanadium pentoxide on human health (the respiratory organs in particular) under chronic inhalation exposure. When analyzing a study design, we paid special attention to description of observation groups, values of exposure and nature of its effects, adverse health outcomes caused by exposure to divanadium pentoxide as well as to a type and a value of a point of departure. We calculated a value of the total (complex) uncertainty factor in order to establish an average annual maximum permissible level of the analyzed chemical. As a result, we suggest a scientifically substantiated (among other things, as per permissible health risk levels) average annual maximum permissible level for divanadium pentoxide, which equals 0.0001 mg/m3. This level is safe for human health under lifetime exposure. It is noteworthy that this level corresponds to ‘low uncertainty’, which indicates its high safety for human health.

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“…Relevance of regulating levels of divanadium pentoxide arises due to its high toxicity, which is determined by several adverse effects occurring under inhalation exposure. Divanadium pentoxide is considered to primarily affect the respiratory organs [1][2][3][4][5][6][7][8][9][10]. However, hazard identification performed in some studies established adverse effects produced by divanadium pentoxide on other organs and systems, for example, eyes 5 [11-15], skin [11], and the immune system as dysfunction of its humoral and cellular components [6,16,17].…”

mentioning

confidence: 99%

Scientific substantiation of average annual maximum permissible level of vanadium pentoxide in ambient air as per permissible health risk

Chetverkina,

Savostikova

2024

Health Risk Analysis

0

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Relevance of this study is determined by the sanitary-epidemiological legislation of the Russian Federation with stipulated requirements to create hygiene standards for environmental factors ensuring their safety for people. These hygienic standards should guarantee absence of impermissible lifetime health risks. Divanadium pentoxide is a chemical that should be mandatorily regulated in ambient air under long-term exposure due to its wide prevalence and high toxicity. An average annual MPL for divanadium pentoxide was established by using systemic analysis of research literature and regulatory documents. According to selection results, three key epidemiological studies were taken for further analysis. They provided evidence of adverse effects produced by divanadium pentoxide on human health (the respiratory organs in particular) under chronic inhalation exposure. When analyzing a study design, we paid special attention to description of observation groups, values of exposure and nature of its effects, adverse health outcomes caused by exposure to divanadium pentoxide as well as to a type and a value of a point of departure. We calculated a value of the total (complex) uncertainty factor in order to establish an average annual maximum permissible level of the analyzed chemical. As a result, we suggest a scientifically substantiated (among other things, as per permissible health risk levels) average annual maximum permissible level for divanadium pentoxide, which equals 0.0001 mg/m3. This level is safe for human health under lifetime exposure. It is noteworthy that this level corresponds to ‘low uncertainty’, which indicates its high safety for human health.

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Association of exposure to environmental vanadium and manganese with lung function among young children: A population-based study

Cited by 5 publications

References 37 publications

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity

Scientific substantiation of average annual maximum permissible level of vanadium pentoxide in ambient air as per permissible health risk

Scientific substantiation of average annual maximum permissible level of vanadium pentoxide in ambient air as per permissible health risk

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