Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016

Sun, Xiaoya; Deng, Yujie; Fang, Lanlan; Ni, Man; Wang, Xinqi; Zhang, Tao; Chen, Yuting; Cai, Guoqi; Pan, Faming

doi:10.1007/s12011-023-03901-y

Cited by 11 publications

(5 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, As and Hg exhibited significant negative correlations with immune-inflammatory markers. Similarly, Xiaoya et al [48] reported that Hg was negatively correlated with SII, and mixture analysis revealed Hg as the main substance in the mixture, with negative correlations with SII. Additionally, Tuntinarawat et al [50] observed that As was found to have a high negative weight on the immune-inflammatory profile, consistent with the results of the present study.…”

Section: Discussionmentioning

confidence: 83%

“…Furthermore, immunoinflammatory response, a post-disease injury response, is of great significance for the identification of early diseases. Accumulating evidence suggests that heavy metal exposure disrupts immune homeostasis and exacerbates inflammation [48]. Inflammation is the body's protective response to adverse environmental factors, wherein the normal physiological activities of tissues and organs are maintained by eliminating damage-inducing factors, clearing denaturetic and necrotic cells, and initiating repair functions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Metal Exposure with Novel Immunoinflammatory Indicators

Zhao,

Chen,

Chen

et al. 2024

Toxics

View full text Add to dashboard Cite

Objective: We aimed to investigate the relationship between metal exposure and novel immunoinflammatory indicators. Methods: Data on adults participating in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018 were analyzed. Various statistical models were employed to assess the association between metal exposure and novel immune-inflammation-related indicators. Additionally, the impact of metal exposure on inflammation in different gender populations was explored. Results: This study included 4482 participants, of whom 51.1% were male. Significant correlations were observed among various metals. Both elastic net (ENET) and linear regression models revealed robust associations between cadmium (Cd), cobalt (Co), arsenic (As), mercury (Hg), and immunoinflammatory indicators. Weighted quantile sum (WQS) and Quantile g-computation (Q-gcomp) models demonstrated strong associations between barium (Ba), Co, and Hg and immunoinflammatory indicators. Bayesian kernel machine regression (BKMR) analysis indicated an overall positive correlation between in vivo urinary metal levels and systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI). Furthermore, Co, As, and Hg emerged as key metals contributing to changes in novel immunoinflammatory indicators. Conclusions: Metals exhibit associations with emerging immunoinflammatory indicators, and concurrent exposure to mixed metals may exacerbate the inflammatory response. Furthermore, this relationship varies across gender populations.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Association of Metal Exposure with Novel Immunoinflammatory Indicators

Zhao,

Chen,

Chen

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

“…Based on 2015–2016 NHANES data, Zhong et al used generalized linear models to assess the independent and joint effects of SII with blood Mn, Cd, and Pb levels, respectively ( 50 ). More recently, using NHANES data, sun et al similarly used univariate models to evaluate the linear and nonlinear relationships between single metal exposures and SII, and analyzed the combined effects of mixed metal exposures on SII ( 11 ). In addition, a study investigating the relationship between co-exposure to PAH and phthalates and SII in children aged 4–12 years showed that concurrent exposure to PAH and phthalates was related to increased inflammation in children, with 1-OHPyr having an important role ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…A cross-sectional study concluded that population exposure to PAH might affect the immunity produced by hepatitis vaccines ( 10 ). Sun et al reported that exposure to heavy metal mixtures was positively correlated with immune responses, and there were synergistic and antagonistic effects of intermetallic interactions on immune responses ( 11 ). A study based on experiments with mice showed that interactions between heavy metals affected autoimmune diseases ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Nie,

Hu,

Xian

et al. 2024

Front. Public Health

View full text Add to dashboard Cite

BackgroundStudies on the association between mixed exposure to common pollutants such as cadmium (Cd), cobalt (Co), lead (Pb), and polycyclic aromatic hydrocarbons (PAHs) with Systemic Immune Inflammatory Index (SII), a novel hemocyte-based inflammatory marker, have not been reported. This study explored the relationship between co-exposure to Cd, Co, Pb, PAHs, and SII.MethodsIn this study, we used data from the National Health and Nutrition Examination Survey and enrolled adults with complete information on Cd, Co, Pb, PAHs, and SII. The linear regression was used to analyze the association of single pollutants with SII. Furthermore, a Bayesian Kernel Machine Regression analysis and a generalized weighted quantile sum regression analysis were used to analyze the association between mixed exposure to Cd, Co, Pb, and six PAHs and SII. We also separated males and females and analyzed the different effects of pollutants on SII, respectively.Results5,176 participants were included in the study. After adjusting for age, gender, race, education, smoking, drinking, physical activity, and sedentary, Cd, Co, 1-OHN, 2-OHN and 2-OHF were positive with SII in the total population. Compared with the 50th percentile, the joint effect of pollutants on SII was positive. In the total population, males, and females, the top contaminant with the highest effect weights on SII were Co, Cd, and 1-OHN, respectively. The result of interaction analysis showed that the low concentrations of Cd had an elevation effect on SII in males.ConclusionThis study found a positive association of mixed exposure to Cd, Co, Pb, and six PAHs with SII, which occurred mainly in females.

show abstract

“…Mechanistically, the in ammatory response caused by metal exposure has been demonstrated. For example, exposure to ne particulate matter PM2.5 bound to metals such as vanadium, arsenic, selenium, cadmium, and lead causes oxidative stress and systemic in ammatory responses [29]; Polymetallic combined exposure was positively correlated with systemic immunoin ammatory index (SII) [30].On the other hand, in ammatory response is one of the important mechanisms of abnormal lipid changes, especially in the process of atherosclerosis formation. The in uence of in ammation on atherosclerosis (AS) is mainly attributed to the theory of endothelial injury [31], in which macrophages, neutrophils, monocytes, and other in ammatory cytokines play an important role.…”

Section: Discussmentioning

confidence: 99%

Association of inflammation-mediated blood heavy metals with plasma atherogenic index: NHANES analysis 2015-2020

Wang,

zhang

2023

Preprint

View full text Add to dashboard Cite

Heavy metal pollutants are widely present in a variety of environments, and several studies have shown that exposure to heavy metals is associated with the risk of atherosclerosis. However, the underlying mechanism of this association remains unclear.AIP, as a biomarker for predicting cardiovascular events, can reflect the risk of atherosclerosis and the severity of blood vessel stenosis. Therefore, to explore the relationship between single metal and combined metal exposure and plasma atherosclerosis index. The study included data from the 2015–2016 and 2017–2020 National Health and Nutrition Examination Surveys (NHANES) and assessed the mediating role of inflammation in adults. In a single metal model, a positive dose-response relationship was observed between the blood metal selenium (Se) and AIP, and a negative correlation between cadmium (Cd) and mercury (Hg) and AIP. We construct weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR).In the WQS model, AIP increased significantly with the increase of the concentration of mixed heavy metals, while in the BKMR model, the results were consistent, with statistical significance. In addition, mediated analysis showed that HS-CRP-mediated elevations of 11.83% of blood selenium-associated AIP indicated that the metal caused an inflammatory response that aggravated atherosclerosis progression.

show abstract

Association of Exposure to Heavy Metal Mixtures with Systemic Immune-Inflammation Index Among US Adults in NHANES 2011–2016

Cited by 11 publications

References 58 publications

Association of Metal Exposure with Novel Immunoinflammatory Indicators

Association of Metal Exposure with Novel Immunoinflammatory Indicators

The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female

Association of inflammation-mediated blood heavy metals with plasma atherogenic index: NHANES analysis 2015-2020

Contact Info

Product

Resources

About