Association of exposure to multiple metals with papillary thyroid cancer risk in China

Zhang, Chi; Wu, Hua-bing; Cheng, Mengxia; Wang, Ling; Gao, Chaobing; Huang, Fen

doi:10.1007/s11356-019-04733-x

Cited by 27 publications

(11 citation statements)

References 49 publications

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“…Further studies are warranted to address the mechanism linking EBDC exposure to thyroid disrupting effects and thyroid cancer in men. It might be important to understand whether any difference in the health effects of specific EBDCs might be related to the release of manganese and zinc ions, consistent with what has been observed in relation to urinary levels of other metals [ 131 , 132 ]. Other mechanisms typical of some but not all EBDC fungicides, such as the oxidative stress and genotoxicity, might also be relevant in human carcinogenesis.…”

Section: Discussionmentioning

confidence: 82%

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

Cocco

2022

IJERPH

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Background. In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC fungicides (Group 3, not classifiable as to human carcinogenicity). A systematic review of the scientific literature was conducted to explore the current evidence. Methods. Human and experimental studies of cancer and exposure to EBDC fungicides (Mancozeb, Maneb, Zineb, and others) and ethylene thiourea (ETU), their major metabolite, published in English as of December 2021, were retrieved using PubMed, the list of references of the relevant reports, and grey literature. Results. The epidemiological evidence of EBDC carcinogenicity is inadequate, with two studies each suggesting an association with melanoma and brain cancer and inconsistent findings for thyroid cancer. Experimental animal studies point at thyroid cancer in rats and liver cancer in mice, while multiple organs were affected following the long-term oral administration of Mancozeb. The mechanism of thyroid carcinogenesis in rats has also been shown to occur in humans. Genotoxic effects have been reported. Conclusions. The results of this systematic review suggest inadequate evidence for the carcinogenicity of EBDC fungicides from human studies and sufficient evidence from animal studies, with positive results on three out of ten key characteristics of carcinogens applying to humans as well. An IARC re-evaluation of the human carcinogenicity of EBDC fungicides is warranted.

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Section: Discussionmentioning

confidence: 82%

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

Cocco

2022

IJERPH

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“…Although the authors noted reduced cell viability with Ni 2+ , Cu 2+ , and Zn 2+ , the effects of Cd 2+ on cell death were most pronounced. Rezaei et al (2019) found higher Cd in sera of TC patients than in their control group (CG) (Birjand City, Iran), while Zhang et al (2019) reported elevated urine Cd levels in 262 PTC samples collected from patients from the Chinese province of Anhui. Malandrino et al (2016) assessed environmental pollution and biocontamination in the volcanic area of Mt.…”

Section: Cadmium and Thyroid Cancermentioning

confidence: 99%

“…A spectrum of toxicity mechanisms (above) can cause structural and functional changes to normal metabolism of the thyroid gland, which is defined in the scientific literature by the term "endocrine disruption" (Patisaul et al 2018). To date, it has been shown that several heavy metals can cause endocrine disruption (Rana 2014) and/or TC (Zhang et al 2019). Moreover, the carcinogenic potential of toxic trace metals is well documented in various human malignancies (Briffa et al 2020;Kim et al 2015;Valko et al 2006;Rehman et al 2018).…”

Section: Trace Metals and Thyroid Cancerogenesismentioning

confidence: 99%

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević

Rovčanin

2021

Expo Health

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Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals.

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“…In all NPCSs, the industrial facilities operated or are still operating, in the vicinity or within urban areas for decades. Evidence of thyroid carcinogenicity of EDs was based on an a priori evaluation by the above-mentioned scientific institutions and advisory committees [17][18][19], as well as relevant literature published in the last eight years [20][21][22][23][24][25][26][27][28][29][30][31][32]. The search for literature published in the last eight years was performed using PubMed and Web of Science databases.…”

Section: Npcss Descriptionmentioning

confidence: 99%

“…According to evaluations from some scientific institutions and advisory committees (World Health Organization and theUnited Nation Environment Programme (2013) [17], European Commission (2012) [18], and European Environment Agency (2012) [19]), the exposure to some EDs (dioxins (PCDDs), particularly 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polychlorinated biphenyls (PCBs), pesticides, and some solvents) might be a risk factor in the development of TC. Furthermore, other studies suggest that, in addition to the above-mentioned substances, chemicals and some heavy metals with an endocrine disrupting activity (polychlorinated dibenzo-p-furans (PCDFs), polybrominated diphenyl ethers (PBDEs), bisphenol A (BPA), flame retardants, phthalates, cadmium (Cd), and lead (Pb)) might also play a role in the etiopathogenesis of TC [20][21][22][23][24][25][26][27][28][29][30][31][32]. Regarding the possible role of heavy metals in promoting thyroid tumorigenesis, Malandrino et al (2020) reports a higher risk of papillary TC in residents in the volcanic area of Mount Etna (Catania province, Southern Italy) [33].…”

Section: Introductionmentioning

confidence: 99%

Incidence of Thyroid Cancer in Italian Contaminated Sites

Benedetti

Zona

Contiero

et al. 2020

IJERPH

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Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15–39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15–39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

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Association of exposure to multiple metals with papillary thyroid cancer risk in China

Cited by 27 publications

References 49 publications

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Incidence of Thyroid Cancer in Italian Contaminated Sites

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