Association of famine exposure and the serum calcium level in healthy Chinese adults

Yang, Yuyu; Deng, Zongquan; Ma, Lingying; Hou, Yuliang; Bi, Yufang; Xu, Yu; Xu, Min; Zhao, Hongyan; Sun, Lin; Tao, Bei; Liu, Jianmin

doi:10.3389/fendo.2022.937380

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…To reduce the bias related to age differences between famine exposure subgroups, an 'age-balanced' method was used by combining post-famine and prefamine births as the control group. 9 Statistical analysis SPSS V.26.0 statistical software was used for data processing and analysis. The t-test, one-way analysis of variance and χ 2 test were used to analyse and compare the characteristics of the population.…”

Section: Definition Of Famine Exposurementioning

confidence: 99%

Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study

Yin,

Zhang,

Feng

et al. 2024

bmjph

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BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease, affecting nearly one-third of the global population. The relationship between early-life famine exposure and MAFLD remains unclear in the multiethnic region of less-developed southwest China.MethodsA total of 18 558 participants who came from the baseline survey of the China Multi-Ethnic Cohort Study in Yunnan were included. Participants were divided into four groups according to birth year, including non-exposed (1962–1978 and 1939–1943), fetal exposed (1959–1961), childhood exposed (1949–1958) and adolescence exposed (1943–1949). Logistic regression analysis was used to explore the relationship between famine exposure in early life and the risk of MAFLD in adulthood.ResultsExperiencing the shock of early-life exposure to famine would affect adulthood MAFLD. Exposure to famine during fetal life and childhood increased the risk of MAFLD in adulthood, with this association being particularly pronounced in Bai populations. Moreover, famine exposure in males during fetal life raised the risk of MAFLD in adulthood.ConclusionWe suggest that adequate nutrition in early life may be beneficial in preventing MAFLD in adulthood. The prevention of chronic liver disease should adopt a whole-life strategy by extending the prevention window beginning from fetal life.

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Section: Definition Of Famine Exposurementioning

confidence: 99%

Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study

Yin,

Zhang,

Feng

et al. 2024

bmjph

View full text Add to dashboard Cite

show abstract

Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis

Huang,

Zeng,

Dai

et al. 2024

Nutr. Diabetes

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Malnutrition early in life increases the later-life risk of noncommunicable diseases, and previous epidemiologic studies have found a link between famine and renal impairment, but no consensus has been reached. This meta-analysis and systematic review were conducted to assess the correlation between early-life famine exposure and the risk of developing renal impairment. Search in Embase, Scopus, Web of Science, PubMed, and Cochrane using keywords that report the correlation between early famine exposure and renal function indicators. RevMan and Stata software were used for data analysis. This meta-analysis contained twelve observational studies. The findings demonstrated a link between prenatal famine exposure and a higher risk of developing chronic kidney disease (CKD) (odds ratio (OR) = 1.73, 95% confidence interval (CI): 1.25, 2.39), a decreased estimated glomerular filtration rate (eGFR) (mean difference (MD) = −10.05, 95% CI: −11.64, −8.46), and increased serum creatinine (Scr) (MD = 0.02, 95% CI: 0.01, 0.03) compared to unexposed individuals. Famine exposure in childhood was associated with decreased eGFR (MD = −9.43, 95% CI: −12.01, −6.84) and increased Scr (MD = 0.03, 95% CI: 0.01, 0.04), but not with CKD (OR = 0.980, 95% CI: 0.53, 1.81). Famine exposure in adolescence and adulthood was associated with decreased eGFR (MD = −20.73, 95% CI: −22.40, −19.06). Evidence certainty was deemed to be of low or extremely low quality. Famine exposure early in life could pose a greater risk of developing renal impairment in adulthood, but this outcome may be driven by uncontrolled age differences between famine-births and post-famine-births (unexposed).

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The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer

Gielecińska,

Kciuk,

Kontek

2024

IJMS

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The key role of calcium in various physiological and pathological processes includes its involvement in various forms of regulated cell death (RCD). The concept of ‘calcicoptosis’ has been introduced as a calcium-induced phenomenon associated with oxidative stress and cellular damage. However, its definition remains controversial within the research community, with some considering it a general form of calcium overload stress, while others view it as a tumor-specific calcium-induced cell death. This review examines ‘calcicoptosis’ in the context of established RCD mechanisms such as apoptosis, necroptosis, ferroptosis, and others. It further analyzes the intricate relationship between calcium dysregulation and oxidative stress, emphasizing that while calcium overload often triggers cell death, it may not represent an entirely new type of RCD but rather an extension of known pathways. The purpose of this paper is to discuss the implications of this perspective for cancer therapy focusing on calcium-based nanoparticles. By investigating the connections between calcium dynamics and cell death pathways, this review contributes to the advancement of our understanding of calcicoptosis and its possible therapeutic uses.

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Association of famine exposure and the serum calcium level in healthy Chinese adults

Cited by 3 publications

References 64 publications

Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study

Exposure to famine during early life and the risk of MAFLD during adulthood: evidence from the China Multi-Ethnic Cohort (CMEC) study

Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis

The Impact of Calcium Overload on Cellular Processes: Exploring Calcicoptosis and Its Therapeutic Potential in Cancer

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