Association of fasting glucose levels with incident atherosclerotic cardiovascular disease: An 8‐year follow‐up study in a Chinese population

Abstract

Highlights• Diabetes other than impaired fasting glucose was associated with increased risk of incident ASCVD after 7.8 years follow-up among 18 610 participants.• Impaired fasting glucose increased the risk of developing diabetes.• Prevention strategy on reducing incidence of diabetes in persons with impaired fasting glucose is critical to improve cardiovascular health status. The association of diabetes with coronary heart disease was more pronounced than that with stroke. Gender and residential differences were also identified.Conclusions: In the present study, IFG was associated with the development of diabetes but not incident ASCVD. Prevention strategies to reduce the development of diabetes in people with IFG are critical to improve cardiovascular health.

Changes in fasting blood glucose status and incidence of cardiovascular disease: The China‐PAR project

“… 34 However, our project previously reported that IFG was still not associated with risk of atherosclerotic CVD when low fasting glucose (LFG) was separately considered. 33 Notably, the association between IFG and CVD might be attenuated in these researches, because of the condition that a large proportion of IFG reverted to NFG during the follow‐up. 35 Hence, multiple measurements are needed to evaluate the effect of changes of FBG on CVD.…”

“…For instance, the Multi‐Ethnic Study of Atherosclerosis (MESA) showed that subjects with IFG did not have an increased risk for CVD events, 32 which might underestimate the actual effect of IFG in contrast to NFG on CVD for regarding low glucose as part of the reference group 34 . However, our project previously reported that IFG was still not associated with risk of atherosclerotic CVD when low fasting glucose (LFG) was separately considered 33 . Notably, the association between IFG and CVD might be attenuated in these researches, because of the condition that a large proportion of IFG reverted to NFG during the follow‐up 35 .…”

“…Meta‐analysis showed IFG based on single measurement was associated with an increased CVD risk, whereas several studies reported inconsistent results. 31 , 32 , 33 For instance, the Multi‐Ethnic Study of Atherosclerosis (MESA) showed that subjects with IFG did not have an increased risk for CVD events, 32 which might underestimate the actual effect of IFG in contrast to NFG on CVD for regarding low glucose as part of the reference group. 34 However, our project previously reported that IFG was still not associated with risk of atherosclerotic CVD when low fasting glucose (LFG) was separately considered.…”

Genetic insights into the risk of metabolic syndrome and its components on stroke and its subtypes: Bidirectional Mendelian randomization

“…Accumulating evidence suggests that higher FBG level significantly increases the risk of stroke and may be regarded as a predictor for stroke. [28][29][30][31] A comprehensive metaanalysis of 102 observational studies suggests that FBG is closely associated with increased risk of stroke. 29 However, no significant relationship between higher FBG levels and stroke was identified in our MR analysis.…”

Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China

“…Accumulating evidence suggests that FBG levels can be used to predict the risk of CVD. 20 25 35 As an adverse consequence of CVD, stroke is closely related to FBG levels. 36 37 Its mechanism may be related to the dysfunction of cerebral microvasculature caused by hyperglycaemic, insulin resistance, obesity and hypertension.…”