Association of Fat-Soluble Vitamins (A, D, and E) Status with Humoral Immune Response to COVID-19 Inactivated Vaccination. A Prospective Cohort Study

Deng, Yao; Huang, Lan; Liu, Peixin; Geng, Xuyang; Lin, Zefang; Zheng, Zemin; Zhan, Meixiao; Zhang, Zhiren; Liu, Junwei; Sun, Taoping

doi:10.2139/ssrn.4346803

Cited by 3 publications

(11 citation statements)

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“…Despite some recent and important achievements, 22–24 there are still controversies about the effect of vitamin D status on antibody response after vaccination or infection 13,22–28 . A study recruiting 97 healthcare workers found that individuals without VDD had an average of 29.3% higher peak antibody response induced by the first dose of the SARS‐CoV‐2 BNT162b2 vaccine 23 .…”

Section: Discussionmentioning

confidence: 99%

Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study

Peng,

Gao,

Liu

et al. 2023

Clinical Respiratory J

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IntroductionEffect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults need to be further explored.MethodsA retrospective, longitudinal, real‐world cohort study was performed. All included cases were divided into vitamin D deficiency (VDD) and non‐VDD (control) groups according to baseline serum 25‐hydroxyvitamin D [25(OH)D] concentration and then into unvaccinated, routinely vaccinated, and booster vaccinated VDD and control subgroups according to vaccination status. Antibody dynamics were observed within six time periods during hospitalization.ResultsA total of 204 adult cases were included, of which 121 (59%) were males; 23 (11%), 31 (15%), and 26 (13%) or 50 (25%), 35 (17%), and 39 (19%) were unvaccinated, routinely vaccinated, and booster vaccinated VDD cases or controls, respectively. The median (interquartile range) for age and baseline 25(OH)D concentration was 42.5 (31–53.5) years and 21.5 (18–25.4) ng/mL, respectively. The IgM titers within 3 to 7 days and 7 to 14 days increased rapidly to 1.8‐fold (P < 0.001) and 3.6‐fold (P < 0.001) those within the first day; the IgG titers increased to 5.8‐fold (P < 0.001) and 10.9‐fold (P < 0.001). Booster vaccinated controls had higher first IgG titers compared with unvaccinated controls (3.1‐fold; P = 0.001) or booster vaccinated VDD cases (2.1‐fold; P = 0.02).ConclusionsBooster vaccination and non‐VDD status may have an interactive boosting effect on IgG production of Omicron variant‐infected adults. Further randomized clinical trials may be needed to determine whether booster vaccination combined with VDD correction improves the humoral immunity to Omicron variants.

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Section: Discussionmentioning

confidence: 99%

Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study

Peng,

Gao,

Liu

et al. 2023

Clinical Respiratory J

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“…Despite enormous scientific interest in exploring various aspects related to COVID‐19 vaccination, the potential association between micronutrients and humoral responses following COVID‐19 vaccination remains understudied. Only a limited number of studies with sample sizes ranging from 97 to 73 254 participants have investigated the associations between circulating concentrations of micronutrients, particularly those involved in immune regulation, and humoral immune responses as well as protection following inoculation with COVID‐19 vaccines 14‐25 . Three studies have reported no association between serum iron or selenium status, as well as concentrations of total zinc, and antibody concentrations or titers in response to COVID‐19 vaccinations 14‐16 .…”

Section: Introductionmentioning

confidence: 99%

“…Three studies have reported no association between serum iron or selenium status, as well as concentrations of total zinc, and antibody concentrations or titers in response to COVID‐19 vaccinations 14‐16 . Nine studies have reported the associations between serum vitamin D concentrations or status (sufficient, deficient, or insufficient) and humoral responses following COVID‐19 vaccinations, yet inconsistent conclusions have been reached 17‐25 . Investigations into the influence of micronutrients on antibody binding affinity and neutralizing capacity against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), crucial parameters for immune protection, are virtually non‐existent.…”

Section: Introductionmentioning

confidence: 99%

“…Investigations into the influence of micronutrients on antibody binding affinity and neutralizing capacity against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), crucial parameters for immune protection, are virtually non‐existent. Evidence on the associations between serum concentrations of copper, vitamin A or E with humoral responses following COVID‐19 vaccinations is scarce 21,25 . This knowledge gap hampers efforts to optimize vaccine efficacy through dietary adjustments.…”

Section: Introductionmentioning

confidence: 99%

“…Only a limited number of studies with sample sizes ranging from 97 to 73 254 participants have investigated the associations between circulating concentrations of micronutrients, particularly those involved in immune regulation, and humoral immune responses as well as protection following inoculation with COVID-19 vaccines. [14][15][16][17][18][19][20][21][22][23][24][25] Three studies have reported no association between serum iron or selenium status, as well as concentrations of total zinc, and antibody concentrations or titers in response to COVID-19 vaccinations. [14][15][16] Nine studies have reported the associations between serum vitamin D concentrations or status (sufficient, deficient, or insufficient) and humoral responses following COVID-19 vaccinations, yet inconsistent conclusions have been reached.…”

Section: Introductionmentioning

confidence: 99%

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Unveiling the micronutrient‐immunity puzzle in inactivated COVID‐19 vaccination: A comprehensive analysis of circulating micronutrient levels and humoral responses in healthy adults

Meng,

Wang,

Zhai

et al. 2024

Journal of Medical Virology

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While micronutrients are crucial for immune function, their impact on humoral responses to inactivated COVID‐19 vaccination remains unclear. We investigated the associations between seven key micronutrients and antibody responses in 44 healthy adults with two doses of an inactivated COVID‐19 vaccine. Blood samples were collected pre‐vaccination and 28 days post‐booster. We measured circulating minerals (iron, zinc, copper, and selenium) and vitamins (A, D, and E) concentrations alongside antibody responses and assessed their associations using linear regression analyses. Our analysis revealed inverse associations between blood iron and zinc concentrations and anti‐SARS‐CoV‐2 IgM antibody binding affinity (AUC for iron: β = −258.21, p < 0.0001; zinc: β = −17.25, p = 0.0004). Notably, antibody quality presented complex relationships. Blood selenium was positively associated (β = 18.61, p = 0.0030), while copper/selenium ratio was inversely associated (β = −1.36, p = 0.0055) with the neutralizing ability against SARS‐CoV‐2 virus at a 1:10 plasma dilution. There was no significant association between circulating micronutrient concentrations and anti‐SARS‐CoV‐2 IgG binding affinity. These findings suggest that circulating iron, zinc, and selenium concentrations and copper/selenium ratio, may serve as potential biomarkers for both quantity (binding affinity) and quality (neutralization) of humoral responses after inactivated COVID‐19 vaccination. Furthermore, they hint at the potential of pre‐vaccination dietary interventions, such as selenium supplementation, to improve vaccine efficacy. However, larger, diverse studies are needed to validate these findings. This research advances the understanding of the impact of micronutrients on vaccine response, offering the potential for personalized vaccination strategies.

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The Effect of High Fat Formula Liquid Feeding on the Value of PCO2 and Duration of Use of Respiratory Aids for COVID-19 Patients with Critical Illness

Febri,

Aliska,

Afriani

2023

Int J Res Rev

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Background: In December 2019, WHO announced the outbreak of COVID-19 disease caused by SARSCOV2. COVID-19 is a global pandemic characterized by high morbidity and mortality. SARS-CoV2 with there are many symptoms, about 20-26% of patients with COVID-19 pneumonia become severe or critical, requiring hospitalization for respiratory support. In Indonesia, COVID-19 has been increasing since 2020, and on February 2021, the Covid-19.go.id page had 1.157.837 confirmed cases, 176.291 active cases, 949.990 recovered, and 31.556 death cases. Acute respiratory complications requiring treatment in the intensive care unit are the main cause of high morbidity and mortality in patients with COVID-19. Nutrition therapy has influenced for outcomes of COVID-19 patients. Methods: The primary purpose of this study was to compare the value of PCO2, and duration of use of respiratory support for COVID-19 patients with critical illness. The result compared the COVID-19 patients who had been administered with high lipid formula nutrition (PULMOSOL) and patients who had been administered with standard liquid formula nutrition. The rate of the intervention group that experienced an increase in PCO2 was 55.6%, higher than those who experienced a decrease in PCO2 (50%). Results: Based on the analysis results, there was no difference in the administration of PULMOSOL and standard formula based on PCO2 in the use of ventilators in COVID-19 critically ill patients in Dr. M Djamil Padang General Hospital (p>0.05) with HR = 1.39 (95% CI 1.55-3.55). In patients with increased PCO2, it was found that the intervention group who died was 55.6%, lower compared to the control group (62.5%). The same in patients with decreased pCO2, group the intervention group who died was 50.0%, higher than the control group (40%). Conclusion: Statistical tests demonstrated there was no relationship between the administration of PULMOSOL and the outcome of critically ill COVID-19 (p>0.05). Keywords: Covid-19, critically ill, nutrition, high lipid formula

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Association of Fat-Soluble Vitamins (A, D, and E) Status with Humoral Immune Response to COVID-19 Inactivated Vaccination. A Prospective Cohort Study

Cited by 3 publications

References 0 publications

Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study

Interactive effect of booster vaccination and vitamin D status on antibody production of Omicron variant‐infected adults: A real‐world cohort study

Unveiling the micronutrient‐immunity puzzle in inactivated COVID‐19 vaccination: A comprehensive analysis of circulating micronutrient levels and humoral responses in healthy adults

The Effect of High Fat Formula Liquid Feeding on the Value of PCO2 and Duration of Use of Respiratory Aids for COVID-19 Patients with Critical Illness

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