Association of FCGR2A p.R131H and CCL2 c.-2518 A&gt;G gene variants with thrombocytopenia in patients with dengue virus infection

Alagarasu, Kalichamy; Bachal, Rupali; Damle, I.M.; Shah, P.S.; Cecilia, D.

doi:10.1016/j.humimm.2015.09.042

Cited by 15 publications

(9 citation statements)

References 22 publications

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“…For example , TNF-α can be released into the plasma after the activation of platelet by DENV; meanwhile, the activated platelets interacting with monocytes can induce monocytes to secrete CXCL8, IL-10 and IL-6 [ 41 , 42 ]. DENV induces platelet synthesizing IL-1β [ 43 ], increasing vascular permeability, especially when it binds to TNFα [ 44 ]; besides, the permeability can be affected by CCL2 which is able to disrupt the tight connections of endothelial cells in blood vessels [ 45 ]; eventually, the exaggerated vascular permeability will induce the occurrence of DENGUE hemorrhagic fever [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV

Zheng

Wang

et al. 2021

Briefings in Bioinformatics

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Background The clinical consequences of SARS-CoV-2 and DENGUE virus co-infection are not promising. However, their treatment options are currently unavailable. Current studies have shown that quercetin is both resistant to COVID-19 and DENGUE; this study aimed to evaluate the possible functional roles and underlying mechanisms of action of quercetin as a potential molecular candidate against COVID-19 and DENGUE co-infection. Methods We used a series of bioinformatics analyses to understand and characterize the biological functions, pharmacological targets and therapeutic mechanisms of quercetin in COVID-19 and DENGUE co-infection. Results We revealed the clinical characteristics of COVID-19 and DENGUE, including pathological mechanisms, key inflammatory pathways and possible methods of intervention, 60 overlapping targets related to the co-infection and the drug were identified, the protein–protein interaction (PPI) was constructed and TNFα, CCL-2 and CXCL8 could become potential drug targets. Furthermore, we disclosed the signaling pathways, biological functions and upstream pathway activity of quercetin in COVID-19 and DENGUE. The analysis indicated that quercetin could inhibit cytokines release, alleviate excessive immune responses and eliminate inflammation, through NF-κB, IL-17 and Toll-like receptor signaling pathway. Conclusions This study is the first to reveal quercetin as a pharmacological drug for COVID-19 and DENGUE co-infection. COVID-19 and DENGUE co-infection remain a potential threat to the world’s public health system. Therefore, we need innovative thinking to provide admissible evidence for quercetin as a potential molecule drug for the treatment of COVID-19 and DENGUE, but the findings have not been verified in actual patients, so further clinical drug trials are needed.

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Section: Discussionmentioning

confidence: 99%

Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV

Zheng

Wang

et al. 2021

Briefings in Bioinformatics

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“…Repeated intra and inter species studies documented the crucial involvement of chemokine and cytokines for the adverse prognosis of JE. Single nucleotide polymorphisms (SNPs) found in CCL2 and CCL5 gene (chromosome 17), in CCR2 and CCR5 gene (chromosome 3) have been related to infectious diseases including West Nile virus 20 , 21 , dengue 22 , 23 , HIV 24 , 25 , Hepatitis C 26 and tuberculosis 27 . However, there are no available reports which relate chemokine and its co-receptor SNPs to JE.…”

Section: Discussionmentioning

confidence: 99%

Significance of CCL2, CCL5 and CCR2 polymorphisms for adverse prognosis of Japanese encephalitis from an endemic population of India

Chowdhury

Khan

2017

Sci Rep

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Japanese encephalitis (JE) is a major contributor for viral encephalitis in Asia. Vaccination programme has limited success for largely populated JE endemic countries like India and disease exposure is unavoidable. Involvement of chemokines and its co-receptors for adverse prognosis of JE have been documented both in vitro and in vivo. Identification of the genetic predisposing factor for JE infection in humans is crucial but not yet established. Therefore, we investigated the association of single nucleotide polymorphisms (SNPs) in chemokines (CCL2 and CCL5) and its co-receptors (CCR2 and CCR5) with their protein level for JE. The study enrolled 87 symptomatic JE cases (mild: severe = 24:63) and 94 asymptomatic controls. Our study demonstrated that CCL2 (rs1024611G), CCL5 (rs2280788G) and CCR2 (rs1799864A) significantly associated with JE (Odds ratio = 1.63, 2.95 and 2.62, respectively and P = 0.045, P = 0.05 and P = 0.0006, respectively). The study revealed that rs1024611G allele was associated with elevated level of CCL2. CCL5 elevation associated with JE mortality having a Cox proportional hazard of 1.004 (P = 0.033). In conclusion, SNPs of chemokine viz. CCL2 (rs1024611G) and its receptor CCR2 (rs1799864A) significantly associated with JE which may serve as possible genetic predisposing factor and CCL5 protein level may act as marker for disease survival.

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“…In addition, Baluni et al 43 reported that the AG genotype of MCP‐1 is associated with neurological sequelae in recovered individuals while MCP‐1‐2518 A/G SNP has no effect with disease susceptibility and severity in Japanese encephalitis. On the other hand, Alagarasu et al 44 studied the ‐2518 A/G SNP of MCP‐1 gene in 122 dengue (89 dengue fever and 33 dengue hemorrhagic fever) patients. They reported that the frequencies of MCP‐1 genotypes were not different between dengue fever, dengue hemorrhagic fever, and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Association of MCP‐1 promotor polymorphism with disease severity of Crimean‐Congo hemorrhagic fever

Bağcı

Bağci

Büyüktuna

et al. 2020

Journal of Medical Virology

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Crimean‐Congo hemorrhagic fever (CCHF) is a thick‐borne viral zoonotic disease. The pathogenesis and the reasons why cases have a mild or severe course in CCHF have not yet been explained. In this study, we investigated the relationship between promoter ‐2518 A/G single‐nucleotide polymorphism (SNP) of the MCP‐1 gene and the clinical course of CCHF. The MCP‐1‐2518 A/G SNP (rs1024611) frequency was examined in 128 virologically/serologically confirmed CCHF patients and 181 healthy controls by using the PCR‐RFLP method. When CCHF patients and controls were compared, no significant difference was found between genotype distributions and allele frequencies of the ‐2518 A/G SNP of MCP‐1 gene (P > .05). Compared to the AA genotype, both AG (P = .016; OR = 2.57) and GG genotype (P = .039; OR = 3.43) were found with significantly higher frequencies in mild/moderate cases than in severe cases. Compared to the AG + GG genotype, AA showed a significant risk for severe CCHF (60.0% vs 38.4%, P = .02; OR = 2.41). In contrast, the AG genotype showed a significant protective effect against severe disease compared to AA + GG genotype (29.1% vs 47.9%, P = .013; OR = 2.58). Compared to mild/moderate cases, the A allele was found to be significantly higher in severe cases (0.745 vs 0.623, P = .039; OR = 1.77). However, no significant relationship was found between fatal and nonfatal cases in terms of genotype or allele frequencies (P > .05). In conclusion, both ‐2518 AA genotype and A allele of MCP‐1 were associated with disease severity, and the AG genotype had a protective effect against a severe disease course in CCHF patients.

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Association of FCGR2A p.R131H and CCL2 c.-2518 A>G gene variants with thrombocytopenia in patients with dengue virus infection

Cited by 15 publications

References 22 publications

Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV

Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV

Significance of CCL2, CCL5 and CCR2 polymorphisms for adverse prognosis of Japanese encephalitis from an endemic population of India

Association of MCP‐1 promotor polymorphism with disease severity of Crimean‐Congo hemorrhagic fever

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