Association of FcγRIIA‐R/H131 polymorphism and systemic lupus erythematosus lupus nephritis risk: A meta‐analysis

Abstract

Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disorder characterized by varieties of manifestations such as organs/ systems damage, for example, involving kidney, joint, skin. 1 This complicated disease mainly affects women in childbearing age. Lupus nephritis (LN) is the most serious complication of SLE, contributing to the bulk of morbidity and mortality in SLE patients. Although the etiology of SLE/LN has not been clarified, genetic, epigenetic, environmental factors have been discovered to correlate with pathogenesis and development of SLE/LN. 2 All these abnormalities may lead to dysfunction of immunity.