2021
DOI: 10.1186/s12882-021-02575-9
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Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study

Abstract: Background Fibroblast growth factor-23 (FGF23) and α-klotho are associated with anemia in patients with chronic kidney disease. In this post hoc analysis of the ASTRIO study (UMIN000019176), we investigated the relationship between FGF23 and α-klotho during treatment with an iron-based phosphate binder, ferric citrate hydrate (FC), compared with non-iron-based phosphate binders in hemodialysis (HD) patients. We examined the effect of iron absorption by FC on the relationship between FGF23 and α… Show more

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“…How this absorption–excretion balance is regulated is not known. Iron and phosphate are essential for the human body; therefore, they are thought to be regulated individually by such as hepcidin [ 21 , 22 ] and fibroblast growth factor-23 [ 23 , 24 ]. Gastrointestinal complications are known to occur in approximately 70% of patients with renal failure [ 25 ].…”
Section: Discussionmentioning
confidence: 99%
“…How this absorption–excretion balance is regulated is not known. Iron and phosphate are essential for the human body; therefore, they are thought to be regulated individually by such as hepcidin [ 21 , 22 ] and fibroblast growth factor-23 [ 23 , 24 ]. Gastrointestinal complications are known to occur in approximately 70% of patients with renal failure [ 25 ].…”
Section: Discussionmentioning
confidence: 99%