2021
DOI: 10.1001/jamaneurol.2021.2403
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Association of Field Position and Career Length With Risk of Neurodegenerative Disease in Male Former Professional Soccer Players

Abstract: Key Points Question What is the association of field position, career length, and playing era with risk of neurodegenerative disease in male former professional soccer players? Findings In this cohort study of 7676 Scottish male former professional soccer players and 23 028 general population control individuals matched by sex, year of birth, and area socioeconomic status, risk of neurodegenerative disease among former soccer players varied by field positio… Show more

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Cited by 99 publications
(111 citation statements)
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“…While heading has always been an integral part of football, there is growing uncertainty surrounding the role repeated head impacts from football heading has on brain health [ 1 ]. A recent cohort study reported that Scottish male professional football players ( n = 7676) were more likely (hazard ratio 3.66; 95% confidence interval [CI] 2.88–4.65; p < 0.001) to be identified with a neurodegenerative disease when compared with matched controls ( n = 23,028) from the general population [ 2 ]. Any impact to the head has the potential to cause a transmission of force to the brain [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…While heading has always been an integral part of football, there is growing uncertainty surrounding the role repeated head impacts from football heading has on brain health [ 1 ]. A recent cohort study reported that Scottish male professional football players ( n = 7676) were more likely (hazard ratio 3.66; 95% confidence interval [CI] 2.88–4.65; p < 0.001) to be identified with a neurodegenerative disease when compared with matched controls ( n = 23,028) from the general population [ 2 ]. Any impact to the head has the potential to cause a transmission of force to the brain [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The risk of neurodegenerative disease in former professional footballers varies by the position they play in and the length of their career—but not by which decade they played in—a landmark study has reported 1…”
mentioning
confidence: 99%
“…Several of the lower SMRs in the former college player cohort are consistent with results in studies of former NFL players 25 , 26 , 27 , 28 , 29 , 52 and may be associated with the “healthy worker effect,” including regular exercise, physical activity, and lower cigarette smoking rates among male college athletes. 53 Results are also similar to those of recent studies of former professional soccer players in Scotland, 54 , 55 which found lower overall mortality and mortality from ischemic heart disease and lung cancer compared with the general population. However, in those studies of former Scottish soccer players, mortality from neurodegenerative disease (including Alzheimer disease, ALS, and Parkinson disease) was higher than that in the general population.…”
Section: Discussionmentioning
confidence: 93%