Association of financial toxicity with quality of life in testicular cancer survivors

Nezu, Kunihisa; Yamashita, Shinichi; Kakimoto, Ken‐ichi; Uemura, Mamoru; Kishida, Takeshi; Kawai, Koji; Nakamura, Toshio; Goto, Takayuki; Osawa, Takahiro; Nishimura, Kazuo; Nonomura, Norio; Negoro, Hiromitsu; Shiraishi, Takeshi; Ukimura, Osamu; Ogawa, Osamu; Shinohara, Nobuo; Suzukamo, Yoshimi; Ito, Akihiro; Arai, Yoichi

doi:10.1111/iju.15039

Cited by 15 publications

(16 citation statements)

References 28 publications

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“…31 Measurement of FT using the financial difficulties item of the EORTC QLQ-C30 was previously used in other studies. 6,32,33…”

Section: Methodsmentioning

confidence: 99%

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Financial Toxicity and Health-Related Quality of Life Profile of Patients With Hematologic Malignancies Treated in a Universal Health Care System

Sparano,

Giesinger,

Gaidano

et al. 2024

JCO Oncol Pract

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PURPOSE We investigated the association of financial toxicity (FT) with the health-related quality of life (HRQoL) profile of patients with hematologic malignancies treated in a universal health care system. METHODS We did a secondary analysis of six multicenter studies enrolling patients with hematologic malignancies. FT was evaluated using the financial difficulties item of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Multivariable linear regression models were used to assess the mean differences in HRQoL scores between patients with or without FT, while adjusting for key potential confounding factors. We also examined the prevalence of clinically important problems and symptoms by the experience of FT, using established thresholds for the EORTC QLQ-C30. Multivariable binary logistic regression analysis was performed to explore the risk factors associated with FT. RESULTS Overall, 1,847 patients were analyzed, of whom 441 (23.9%) reported FT. We observed statistically and clinically relevant worse scores for patients with FT compared with those without FT for all the EORTC QLQ-C30 scales. The three largest clinically relevant mean differences between patients with and without FT were observed in pain (∆ = 19.6 [95% CI, 15.7 to 23.5]; P < .001), social functioning (∆ = –18.9 [95% CI, –22.5 to –15.2]; P < .001), and role functioning (Δ = –17.7 [95% CI, –22.1 to –13.3]; P < .001). Patients with FT tended to report a higher prevalence of clinically important problems and symptoms across all EORTC QLQ-C30 scales. In the univariable and multivariable analyses, the presence of FT was associated with the presence of comorbidities, an Eastern Cooperative Oncology Group performance status ≥1, and not receiving a salary. CONCLUSION Patients with hematologic malignancies treated in the setting of a universal health care system who experience FT have a worse HRQoL profile compared with those without FT.

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“…31 Measurement of FT using the financial difficulties item of the EORTC QLQ-C30 was previously used in other studies. 6,32,33…”

Section: Methodsmentioning

confidence: 99%

“…31 Measurement of FT using the financial difficulties item of the EORTC QLQ-C30 was previously used in other studies. 6,32,33 HRQoL was evaluated using the functioning and symptoms scales and the global health status/QoL (GHS/QoL) scale of…”

Section: Assessment Of Ft and Hrqolmentioning

confidence: 99%

Financial Toxicity and Health-Related Quality of Life Profile of Patients With Hematologic Malignancies Treated in a Universal Health Care System

Sparano,

Giesinger,

Gaidano

et al. 2024

JCO Oncol Pract

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“…And each item was given on a Likert-type format with 5 options (1 = none of the time, 5 = all of the time). The total score ranges from 10 to 50, with the following stages: none (10)(11)(12)(13)(14)(15)(16)(17)(18)(19), mild (20)(21)(22)(23)(24)(25)(26)(27)(28)(29), moderate (30)(31)(32)(33)(34)(35)(36)(37)(38)(39), and severe (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). Wu and Jiang translated it into Chinese with satisfactory internal consistency coe cient (Cronbach's α = 0.91) [38].…”

Section: Self-perceived Burden Scale (Spbs)mentioning

confidence: 99%

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Zhang,

Xu,

Yang

et al. 2024

Preprint

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Background Although immunotherapy has the potential to prolong the median survival time and overall survival of patients with lung cancer, it is also a driver of immune related adverse events, which may directly affect the therapeutic effect and reduce quality of life (QOL). Attention to measure QOL in lung cancer patients undergoing immunotherapy is under-explored because of the therapy’s relative novelty. And a great deal of empirical researches has indicated the important influence of financial toxicity (FT) and self-perceived burden (SPB) on QOL. However, yet no research has ever clarified the relationship among FT, SPB, and QOL simultaneously. Hence, the purpose of this study is to understand the level of QOL of lung cancer patients undergoing immunotherapy, and attempt to clarify the potential mediating roles of SPB on the relationship between FT and QOL. Methods A convenience sample of 342 lung cancer patients undergoing immunotherapy was recruited from a cancer hospital from October 2022 to April 2023 in this cross-sectional study. Participants were requested to complete the structured questionnaires: sociodemographic and clinical questionnaire, Functional Assessment of Cancer Therapy–Lung (FACT-L), Self -Perceived Burden Scale (SPBS) and COmprehensive Score for financial Toxicity (COST). Data were subjected to Pearson correlation analysis and bootstrapping analysis in the structural equation modelling. Results The total score of FACT-L was (79.90 ± 15.84) points in 322 lung cancer patients administrated with immunotherapy. FT (β = 0.37, P < 0.01) and SPB (β = -0.27, P < 0.01) had a direct effect on QOL. In addition, SPB partly mediated the association between FT and QOL, and the standardized indirect effect was 0.19, accounting for 33.9% of the total effect. Conclusions The present study revealed that lung cancer patients undergoing immunotherapy experienced a lower QOL. And higher financial burden resulted in greater self-perceived burden, thus associated with inferior QOL. It is imperative for healthcare providers to routinely assessed QOL, financial toxicity or risk and self- perceived burden for lung cancer patients undergoing immunotherapy, and assist those patients in understanding the potential financial risk of each choice and help them take more active roles in their routine clinical care.

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“…10 Recently, a multi-institutional, cross-sectional study was conducted to evaluate health-related QOL and fertility among TC survivors using the EORTC QLQ-TC26 in Japan. 12,[18][19][20] The EORTC QLQ-TC26 includes the questionnaire about sexual functioning; erectile and ejaculatory functions. Therefore, we evaluated sexual function after treatment for TC using the EORTC QLQ-TC26 and analyzed the impact of treatment on sexual function among TC survivors.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, we reported that ejaculation disorders occurred at a high rate following RPLND, and TC survivors after RPLND showed lower sexual QOL in a single‐institutional study 10 . Recently, a multi‐institutional, cross‐sectional study was conducted to evaluate health‐related QOL and fertility among TC survivors using the EORTC QLQ‐TC26 in Japan 12,18–20 . The EORTC QLQ‐TC26 includes the questionnaire about sexual functioning; erectile and ejaculatory functions.…”

Section: Introductionmentioning

confidence: 99%

Sexual function using the EORTC QLQ‐TC26 in testicular cancer survivors: A multi‐institutional, cross‐sectional study

et al. 2023

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ObjectiveTo evaluate sexual function after treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Testicular Cancer 26 (EORTC QLQ‐TC26) questionnaire in Japanese testicular cancer (TC) survivors in a multi‐institutional, cross‐sectional study.MethodsThis study enrolled TC survivors who visited any of eight high‐volume institutions in Japan from 2018 to 2019. After obtaining informed consent, participants completed the EORTC QLQ‐TC26 questionnaires. We evaluated sexual function after treatment for TC using the EORTC QLQ‐TC26 and analyzed the impact of treatment on sexual function in TC survivors.ResultsA total of 567 TC survivors responded to the EORTC QLQ‐TC26. Median age at the time of response was 43 years (interquartile range [IQR] 35–51 years), and median follow‐up period after treatment was 5.2 years (IQR 2.2–10.0 years). Sexual function, particularly ejaculatory function, was significantly lower after post‐chemotherapy retroperitoneal lymph node dissection (PC‐RPLND) than after Surveillance or Chemotherapy groups (p < 0.05). In the PC‐RPLND group, nerve‐sparing procedure preserved postoperative ejaculatory function after RPLND compared with the non‐nerve‐sparing and offered improved ejaculatory function with time. On multivariate analysis, RPLND was a significant predictor of post‐treatment ejaculatory dysfunction, particularly without nerve‐sparing (odds ratio 3.0, 95% CI 1.2–7.7, p < 0.05). In addition, TC survivors with nerve‐sparing RPLND had higher sexual activity than those without.ConclusionThis survey of the EORTC QLQ‐TC26 showed that sexual function and activity in TC survivors after RPLND was reduced in the absence of nerve‐sparing techniques.

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Association of financial toxicity with quality of life in testicular cancer survivors

Cited by 15 publications

References 28 publications

Financial Toxicity and Health-Related Quality of Life Profile of Patients With Hematologic Malignancies Treated in a Universal Health Care System

Financial Toxicity and Health-Related Quality of Life Profile of Patients With Hematologic Malignancies Treated in a Universal Health Care System

Influence of financial toxicity on quality of life in lung cancer patients undergoing immunotherapy: the mediating effect of self-perceived burden

Sexual function using the EORTC QLQ‐TC26 in testicular cancer survivors: A multi‐institutional, cross‐sectional study

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