Association of Fludeoxyglucose F 18–Labeled Positron Emission Tomography and Computed Tomography With the Detection of Oropharyngeal Cancer Recurrence

Sivarajah, Shanmugappiriya; Isaac, André; Cooper, Tim; Zhang, Han; Puttagunta, Lakshmi; Abele, Jonathan; Biron, Vincent L.; Harris, Jeffrey R.; Seikaly, Hadi; Connell, Daniel A. O’

doi:10.1001/jamaoto.2018.2143

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…HNSCC is a heterogeneous group of cancers that caused by squamous cell abnormalities 19 . The longtime survival rate of HNSCC remains poor due to the high rate of recurrence and distant metastasis 20 . It has been suggested that metabolic reprogramming is a cancer hallmark, and abnormal fatty acid metabolism is related to the malignant phenotype in HNSCC, including chemoresistance, relapse and metastasis 21 .…”

Section: Discussionmentioning

confidence: 99%

Identify an Innovative Fatty Acid Metabolism-Related Gene in Head and Neck Squamous Cell Carcinoma

Liu

et al. 2023

Preprint

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Background: Head and neck squamous cell carcinomas (HNSCCs) are the sixth largest group of malignancies worldwide. Due to the highly aggressive, heterogeneousness and tumor microenvironment, the variable prognosis of HNSCC patients is changeable. Fatty acid metabolism-related genes (FAMGs) play a vital role in the development of malignant tumors, but the role in HNSCC is still unclear. The purpose of this study was to establish a reliable prognostic model based on FAMGs for evaluating the prognosis and immunotherapy of HNSCC patients and find the key prognostic genes to provide guidance for the early diagnosis and treatment. Methods: We obtained cancer-related data from various public databases. The FAMGs risk score model was established and proved by a combination of univariate Cox analysis and least absolute shrinkage and selection operator (LASSO) regression analysis. Combining risk scores and clinical characteristics, a nomogram was created and validated. Subsequently, the function, immune difference, immune infiltration, enrichment analysis, and hub genes of the groups with high‐ and low‐risk scores were analyzed. Consequently, the mode's validity was evaluated comprehensively by combining single gene analysis and pan-cancer analysis. Results: we screened out 73 differentially expressed FAGMs and 9 genes associated with prognosis to construct a prognostic risk score model for genes related to fatty acid metabolism. The FAMGs signature was an independent prognostic factor for HNSCC, and patients in the low-risk group had higher overall survival (OS) than those in the high-risk group. In addition, we found differences in immune cell infiltration and enrich pathways between the different risk score groups. Finally, through the risk assessment model, combined with multiple databases, PTGDS, a high-risk and prognosis-related gene, was screened. And it showed a trend of low expression in many cancers, which predicted the prognosis of many cancers, especially in HNSCC. Conclusion: Metabolism-related genes affect the prognosis and survival of patients with HNSCC through affecting tumor microenvironment. And PTGDS can predict the survival and prognosis of cancer patients as an independent effective prognostic factor, particularly in HNSCC.

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Section: Discussionmentioning

confidence: 99%

Identify an Innovative Fatty Acid Metabolism-Related Gene in Head and Neck Squamous Cell Carcinoma

Liu

et al. 2023

Preprint

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“…This is usually followed by routine clinical surveillance (history, physical examination, and endoscopic assessment) with or without subsequent surveillance imaging . The prognostic value of post-RT PET/CT has been demonstrated in multiple studies, with excellent negative predictive value in the definitive RT and postoperative RT (after a curative surgery) settings . Clear and concise results must be communicated to the oncology team that is treating the patient for this prognostic value to translate into improved patient care in the clinic.…”

Section: Discussionmentioning

confidence: 99%

Discordance Between Oncology Clinician–Perceived and Radiologist-Intended Meaning of the Postradiotherapy Positron Emission Tomography/Computed Tomography Freeform Report for Head and Neck Cancer

Patel

Schroeder

Bunch

et al. 2022

JAMA Otolaryngol Head Neck Surg

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ImportanceAssessment of response after radiotherapy (RT) using 18F–fluorodeoxyglucose positron emission tomography (PET) with computed tomography (CT) is routine in managing head and neck squamous cell carcinoma (HNSCC). Freeform reporting may contribute to a clinician’s misunderstanding of the nuclear medicine (NM) physician’s image interpretation, with important clinical implications.ObjectiveTo assess clinician-perceived freeform report meaning and discordance with NM interpretation using the modified Deauville score (MDS).Design, Setting, and ParticipantsIn this retrospective cohort study that was conducted at an academic referral center and National Cancer Institute–designated Comprehensive Cancer Center and included patients with HNSCC treated with RT between January 2014 and December 2019 with a posttreatment PET/CT and 1 year or longer of follow-up, 4 masked clinicians independently reviewed freeform PET/CT reports and assigned perceived MDS responses. Interrater reliability was determined. Clinician consensus–perceived MDS was then compared with the criterion standard NM MDS response derived from image review. Data analysis was conducted between December 2021 and February 2022.ExposuresPatients were treated with RT in either the definitive or adjuvant setting, with or without concurrent chemotherapy. They then underwent posttreatment PET/CT response assessment.Main Outcomes and MeasuresClinician-perceived (based on the freeform PET/CT report) and NM-defined response categories were assigned according to MDS. Clinical outcomes included locoregional control, progression-free survival, and overall survival.ResultsA total of 171 patients were included (45 women [26.3%]; median [IQR] age, 61 [54-65] years), with 149 (87%) with stage III to IV disease. Of these patients, 52 (30%) received postoperative RT and 153 (89%) received concurrent chemotherapy. Interrater reliability was moderate (κ = 0.68) among oncology clinicians and minimal (κ = 0.36) between clinician consensus and NM. Exact agreement between clinician consensus and the NM was 64%. The NM-rated MDS was significantly associated with locoregional control, progression-free survival, and overall survival.Conclusions and RelevanceThe results of this cohort study suggest that considerable variation in perceived meaning exists among oncology clinicians reading freeform HNSCC post-RT PET/CT reports, with only minimal agreement between MDS derived from clinician perception and NM image interpretation. The NM use of a standardized reporting system, such as MDS, may improve clinician-NM communication and increase the value of HNSCC post-RT PET/CT reports.

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“…14 Alternatively, several studies have reported the benefits of PET/CT imaging in patients with head and neck cancer. Specifically, the use of PET/CT surveillance can spare patients unnecessary neck dissections, 15,16 and PET/CT has higher diagnostic performance in the detection of disease recurrence compared with CT. [17][18][19][20][21] In addition, 2 prior studies, one from the United Kingdom and one from Australia, demonstrated that PET/CT surveillance can reduce health care costs by decreasing the need for radical neck dissections and by stratifying disease response, which allowed for fewer follow-up visits. 16,22 Longterm benefits of posttreatment imaging also have been reported, with adherence to surveillance imaging found to be an independent predictor of survival 5 to 10 years after the completion of therapy.…”

Section: Discussionmentioning

confidence: 99%

Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer

Morgan

Eguchi

McDermott

et al. 2020

Cancer

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Background Persistent controversy exists with regard to how and when patients with head and neck cancer should undergo imaging after definitive therapy. The current study was conducted to evaluate whether the type of imaging modality used in posttreatment imaging impacts cancer‐specific survival for patients with advanced head and neck squamous cell carcinoma. Methods A retrospective study of National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) program–Medicare‐linked data in patients with an advanced stage of the 3 most common head and neck malignancies (oral cavity, oropharynx, and larynx) was conducted. Hazard ratios and 95% CIs for cancer‐specific survival were estimated for patients diagnosed with any of these cancers between 2006 and 2015. Results Significant improvement with regard to cancer‐specific survival was observed among patients with American Joint Committee on Cancer stage III and stage IVA laryngeal cancer who underwent positron emission tomography (PET) and/or computed tomography (CT) imaging during the first 6 months after receipt of definitive treatment (hazard ratio, 0.517; 95% CI, 0.33‐0.811) compared with those who underwent CT. There was a trend toward an improvement in cancer‐specific survival among patients with oral cavity or oropharyngeal malignancies who underwent PET/CT imaging, but it did not reach statistical significance. Conclusions Compared with CT imaging, posttreatment imaging with PET was associated with improved survival in patients with advanced laryngeal carcinoma.

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Association of Fludeoxyglucose F 18–Labeled Positron Emission Tomography and Computed Tomography With the Detection of Oropharyngeal Cancer Recurrence

Cited by 9 publications

References 25 publications

Identify an Innovative Fatty Acid Metabolism-Related Gene in Head and Neck Squamous Cell Carcinoma

Identify an Innovative Fatty Acid Metabolism-Related Gene in Head and Neck Squamous Cell Carcinoma

Discordance Between Oncology Clinician–Perceived and Radiologist-Intended Meaning of the Postradiotherapy Positron Emission Tomography/Computed Tomography Freeform Report for Head and Neck Cancer

Comparative effectiveness of posttreatment imaging modalities for Medicare patients with advanced head and neck cancer

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