Association of focal nodular hyperplasia and hepatic hemangioma

Mathieu, Didier; Zafrani, Élie Serge; Anglade, Marie-Christine; Dhumeaux, Daniel

doi:10.1016/0016-5085(89)91429-7

Cited by 135 publications

(53 citation statements)

References 20 publications

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“…14c,d) has been reported in approximately 20% of cases of patients having a concomitant FNH, a prevalence that is higher than that observed in the general population. A common physiopathological mechanism may explain this association, which is believed to result from a focal disturbance of the liver blood supply facilitating a hyperplastic response and subsequent development of these benign tumours [43,44].…”

Section: Associated Liver Abnormalitiesmentioning

confidence: 99%

Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis

et al. 2007

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Haemangiomas are common focal liver lesions, generally detected in the work-up of asymptomatic patients. From the pathological point of view, they can be classified as small (capillary) or large, with cavernous vascular spaces that may show thrombosis, calcifications and hyalinisation. The polymorphic imaging appearance of haemangiomas depends on their histological features and flow pattern. The widespread use of cross-sectional imaging has allowed an increased detection rate and a better characterisation of this benign tumour. Recent developments of ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI) providing high spatial and temporal resolution, together with the use of new contrast agents and/or pulse sequences has broadened the spectrum of imaging findings, contributing to diagnostic refinement in difficult cases. The scope of the present article is to provide an overview of the range of appearances of haemangiomas, explored with recent crosssectional imaging modalities, emphasising its atypical findings as explored by temporally resolved contrast-enhanced imaging.

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Section: Associated Liver Abnormalitiesmentioning

confidence: 99%

Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis

et al. 2007

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“…FNH is thought to be a non-neoplastic tumor that may arise as part of a vascular malformation/ hamartoma; hemangioma; or reaction to a previous, localized insult, such as ischemia (103)(104)(105). FNH was originally called focal cirrhosis because of its resemblance to cirrhosis microscopically.…”

Section: Focal Nodular Hyperplasiamentioning

confidence: 99%

Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems

Ferrell

2000

Modern Pathology

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“…Some investigators have speculated that the primary lesion of FNH is a vascular abnormality that induces a reactive hyperplasia of hepatocytes and bile ducts [4]. Associated hepatic hemangiomas are seen in 14-23% of cases [6,10,11], and other associated vascular anomalies have also been described [12]. A recent study using modern molecular biology techniques has shown that most cases of FNH are due to a monoclonal proliferation of hepatocytes, a feature shared with hepatic adenoma and carcinoma [13].…”

Section: Discussionmentioning

confidence: 99%

Massive hemorrhage and infarction complicating focal nodular hyperplasia of the liver

Bathe¹,

Mies²,

D³

et al. 2003

HPB: Official Journal of The International Hepato Pancreato Bil

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BackgroundSpontaneous infarction or hemorrhage of focal nodular hyperplasia (FNH) has rarely been reported in the literature. Case outlineA 43-year-old woman presented with upper abdominal pain and anemia. CT scan showed an enormous perihepatic hematoma. Trisegmentectomy successfully dealt with the problem. ConclusionAlthough conservative management of FNH is often adopted, this case illustrates that these lesions can undergo massive bleeding.

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Association of focal nodular hyperplasia and hepatic hemangioma

Cited by 135 publications

References 20 publications

Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis

Liver haemangioma: common and uncommon findings and how to improve the differential diagnosis

Liver Pathology: Cirrhosis, Hepatitis, and Primary Liver Tumors. Update and Diagnostic Problems

Massive hemorrhage and infarction complicating focal nodular hyperplasia of the liver

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