Association of follicle stimulating hormone and serum lipid profiles in postmenopausal women

Xu, Zhengfen; Gu, Shuiqin; Wu, Xiaojie; Zhou, Ying; Li, Huan; Tang, Xuedong

doi:10.1097/md.0000000000030920

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…But it can explain the significant high level of OA II compared to OA II (Table 1). Like FSH, high levels of LH in post-menopausal women with OA were reported to enhance the progression of OA disease 21 . Furthermore, TGs level in OA patients was clearly increased compared to healthy women at both pre-and postmenopausal age.…”

Section: Resultsmentioning

confidence: 99%

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Ghanim,

Hasan

2024

Baghdad Sci.J

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Osteoarthritis (OA) is not an autoimmune but a chronic inflammatory disease affecting the joints of humans due to mechanical stress mostly in the knees and the hip. In OA a modification of the cartilage is encountered causing a pain in the joints upon movement. Coll2-1NO2 is a specific sequence of amino acids produced from the degradation of type II collagen, which is abundantly found in the cartilage, followed by a nitration in the tyrosine residue as a consequence of stress-inflammatory events. In this study, Coll2-1NO2 is used as a biomarker of OA to predict the inflammatory stress condition as well as the cartilage degradation in pre- and post-menopausal women. The results showed a significant increase of serum Coll2-1NO2 in pre- and post-menopausal women with OA compared to pre- and post-menopausal health women, at similar body mass index category (overweight). Pearson’s correlation analysis showed non-significant association between Coll2-1NO2 and other studied parameters. Moreover, ROC analysis showed a very excellent sensitivity of Coll2-1NO2 as a prognostic biomarker for OA disease in pre- and post-menopausal women

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Section: Resultsmentioning

confidence: 99%

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Ghanim,

Hasan

2024

Baghdad Sci.J

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“…The gonadotropin -releasing hormone cells in the adenohypophysis co-secrete luteinizing hormone (LH), a glycoprotein hormone, alongside follicle-stimulating hormone (anterior pituitary). The hypothalamus, the pituitary, and the gonads are all components of the neurological pathway that luteinizing hormone is a part of gonadotropin-releasing hormone (GnRH) stimulates LH release through this route, which is blocked by estrogen in females and androgen in males (Xu et al, 2022). LH performs a variety of tasks that are different for men and women.…”

Section: Introductionmentioning

confidence: 99%

Association Between Female Hormones (Fsh, Lh, and Estrogen) as Well as Hyperlipidemia and Obesity in Al- Najaf Holy City

Jubair

2024

JMGCB

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An excessively high level of lipids, or fat, in the blood is called hyperlipidemia. The levels of hormones in females were examined, along with their correlation with elevated body fat and impact on cardiovascular conditions. The information was gathered in Najaf City between November 1, 2023, and December 20, 2023. The results of this study showed that the concentrations for a hormone that promotes follicle development within samples had increased by 58%. LH increased in 50% of the samples that were analyzed. Better pubertal development has been associated with elevated FSH levels in the blood. Improved metabolism has been associated with an increase in blood FSH. Moreover, nonlinear correlations were found between adiposity measures and serum FSH levels.

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Follicle-Stimulating Hormone and Diabetes in Postmenopausal Women: A Systematic Review and Meta-Analysis

Saei Ghare Naz,

Farhadi-Azar,

Noroozzadeh

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Background Today, co-occurrence of hormonal changes during menopause and the risk of cardio-metabolic disorders have been well studied. We aimed to explore the association of circulating levels of follicle-stimulating hormone (FSH) with diabetes (DM) among postmenopausal women. Method In this Systematic review and meta-analysis the search was performed on PubMed, Scopus, Web of sciences, Epistemonikos, and Cochrane library until the September 2023. Risk of bias was assessed by Newcastle-Ottawa Quality Assessment Scale. Pooled estimates of mean differences in FSH levels among diabetic postmenopausal women compared to those without diabetes were performed. Also, the correlation between FSH and fasting blood glucose (FBG)/Insulin/Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) as well as the pooled effect sizes with their 95% confidence intervals (CIs) for risk of DM were calculated. Results In this study, 14 articles, including 7,878 postmenopausal women, met eligibility criteria and were further analyzed. Most of the included studies had a low/moderate risk of bias. Women with DM had significantly lower FSH levels than those without DM (standardized mean difference [95% CI] -0.751, 95% CI-1.129 to -0.372, I2 = 82.46%, n = 1416). The pooled effect size (ES) for diabetes was 0.861 (95% CI: 0.740-1.001; I2 = 80.11%). The pooled risk estimate for DM based on the categorical FSH levels (high versus low) was (HR = 0.550; 95% CI, 0.356 to 0.850, I2 = 0). The significant inverse correlation was found between FSH levels and glycemic parameters [FBG (r= -0.285; 95%CI -0.441 to -0.113; n = 1229), HOMA-IR (r = -0.241; 95%CI -0.378 to -0.0924; n = 1229) and Insulin (r = -0.337; 95%CI -0.434 to -0.232; n = 959)]. There were no statistically significant differences between estradiol levels among diabetic and non-diabetic groups; however the SMD for luteinizing hormone was similar to that reported for FSH. Conclusion The available data indicated an indirect association between FSH levels and glucose disturbances among postmenopausal women; notwithstanding heterogeneity among included studies, and the complexity of various influential factors needs to be considered. Further efforts should be made to clarify the underlying mechanisms.

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Association of follicle stimulating hormone and serum lipid profiles in postmenopausal women

Cited by 4 publications

References 24 publications

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Evaluating Coll2-1NO2 Level in Pre- and Post-menopausal Iraqi Women with Osteoarthritis

Association Between Female Hormones (Fsh, Lh, and Estrogen) as Well as Hyperlipidemia and Obesity in Al- Najaf Holy City

Follicle-Stimulating Hormone and Diabetes in Postmenopausal Women: A Systematic Review and Meta-Analysis

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