Association of follicle-to-oocyte index and clinical pregnancy in IVF treatment: A retrospective study of 4,323 fresh embryo transfer cycles

Li, Peiyi; Chen, Zhiyun

doi:10.3389/fendo.2022.973544

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Women characterized by a reduced ovarian sensitivity (or "hypo-response") are characterized by reduced the number of eggs retrieved despite the normal ovarian reserve. Evidence indicates that hypo-response is typically observed in women with reduced IVF prognosis (5)(6)(7)(8)(9). So far, several ovarian sensitivity indicators have been proposed (10,11).…”

Section: Introductionmentioning

confidence: 99%

The impact of Resveratrol on the outcome of the in vitro fertilization: a pilot randomized controlled trial

Conforti,

Iorio,

Girolamo

et al. 2024

Preprint

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Background Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This pilot trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women were randomized to receive or placebo or Resveratrol (150 mg twice per day) for three months preceding the ovarian stimulation (OS). All patients were stimulated with a starting dose of recombinant FSH ranging between 150 and 300 IU according to age and ovarian reserve. GnRH antagonist flexible protocol was adopted for pituitary suppression. Triggering was performed with urinary hCG (10.000 IU). Results The study was conducted between January 2019 and December 2022 with aa total of 37 cases and 33 controls were recruited. A statistically significant increase in the follicle output rate (FORT) and follicle-to oocyte index (FOI) in women treated with resveratrol was observed compared with control group (0.92 versus 0.77 [p = 0.02], and 0.77 versus 0.64 [p = 0.006], respectively). No statistically significant differences in the number of oocytes retrieved, biochemical pregnancy, clinical pregnancy and live birth rates were observed between groups. Conclusions Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS.

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Section: Introductionmentioning

confidence: 99%

The impact of Resveratrol on the outcome of the in vitro fertilization: a pilot randomized controlled trial

Conforti,

Iorio,

Girolamo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Women characterized by a reduced ovarian sensitivity (or “hypo-response”) are characterized by reduced the number of eggs retrieved despite the normal ovarian reserve markers. Evidence indicates that hypo-response is typically observed in women with reduced IVF prognosis [ 6 – 10 ]. So far, several ovarian sensitivity indicators have been proposed [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial

Conforti,

Iorio,

Di Girolamo

et al. 2024

J Ovarian Res

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Background Resveratrol is a natural polyphenolic compound present in plants and red wine with many potential health benefits. This compound has various anti-inflammatory and anti-tumor properties and can improve cellular mitochondrial activity. This trial was designed to evaluate the effect on the outcome of IVF of Resveratrol supplementation in women > 35 years with good ovarian reserve (AMH > 1.2 ng/ml). Women were randomized to receive or placebo or Resveratrol (150 mg per day) for three months preceding the ovarian stimulation (OS). All patients were stimulated with a starting dose of recombinant FSH ranging between 150 and 300 IU according to age and ovarian reserve. GnRH antagonist flexible protocol was adopted for pituitary suppression. Triggering was performed with urinary hCG (10.000 IU). Results The study was conducted between January 2019 and December 2022 with aa total of 37 cases and 33 controls were recruited. No statistically significant differences in the number of oocytes retrieved, biochemical pregnancy, clinical pregnancy and live birth rates were observed between women treated with resveratrol and control group. A statistically significant increase in the follicle output rate (FORT) and follicle-to oocyte index (FOI) was observed in women treated with resveratrol-based nutraceutical (0.92 versus 0.77 [p = 0.02], and 0.77 versus 0.64 [p = 0.006], respectively). Conclusions Preliminary results from this study indicate that pre-treatment with resveratrol may improve ovarian sensitivity to exogenous FSH, which in turn may decrease the risk of hypo-response to OS in advanced reproductive age women.

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Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes: a retrospective cohort study of 12,218 fresh transfer cycles

Wang,

Tan,

Ding

et al. 2024

Reproductive and Developmental Medicine

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Objective: To investigate the potential relationships among the ovarian response prediction index (ORPI), follicle-oocyte index (FOI), and clinical pregnancy rate (CPR) in women undergoing their first in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) fresh cycle transfer. Methods: In this retrospective cohort study, we included 12,218 women who underwent their first IVF/ICSI-ET cycle between December 2014 and January 2021. The primary and secondary outcomes of our study were CPR and cumulative live birth rate (CLBR), respectively. The data were divided into three groups according to the ORPI and FOI tertiles. Multivariate logistic regression analyses, stratification analyses, interaction, restricted cubic splines, and receiver operating characteristic (ROC) curves were constructed to identify the relationships among ORPI, FOI, and CPR. Results: A statistically significant increase in CPR was detected from the lowest to the highest tertile group (ORPI: 48.12%, 54.07%, and 53.47%, P <0.001; FOI:49.99%, 52.95%, and 52.71%, P=0.012). A higher CLBR was observed in the high group (ORPI: 38.63%, 44.62%, and 44.19%, P <0.001; FOI: 41.02%, 43.78%, and 42.59%, P=0.039). Multivariate logistic regression analysis revealed no statistically significant differences between ORPI, FOI, and neither CPR [odds ratio (OR) (95% confidence interval (CI), 0.99 (0.97-1.00) vs. (1.02 (0.84-1.24)] nor CLBR [OR (95% CI), 0.99 (0.97-1.01) vs. 0.99 (0.81-1.20)]. No significant association was found among FOI, ORPI, and CPR, even in the subgroups. Restricted cubic spline analyses indicated the existence of a nonlinear relationship across the entire range of FOI and ORPI. The ORPI and FOI variables had poor predictive ability (AUC< 0.60) for CPR. Conclusions: Both ORPI and FOI are not reliable predictors of clinical pregnancy or live birth outcomes in fresh embryo transfers. Clinicians and researchers should avoid using FOI and ORPI to assess pregnancy outcomes after fresh embryo transfer because of their limited relevance and predictive value.

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Association of follicle-to-oocyte index and clinical pregnancy in IVF treatment: A retrospective study of 4,323 fresh embryo transfer cycles

Cited by 4 publications

References 33 publications

The impact of Resveratrol on the outcome of the in vitro fertilization: a pilot randomized controlled trial

The impact of Resveratrol on the outcome of the in vitro fertilization: a pilot randomized controlled trial

The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial

Effects of ovarian response prediction index and follicle-oocyte index on pregnancy outcomes: a retrospective cohort study of 12,218 fresh transfer cycles

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