Association of Frailty Syndrome in the Elderly With Higher Blood Pressure and Other Cardiovascular Risk Factors

Bastos-Barbosa, Rachel Gabriel; Ferriolli, Eduardo; Coelho, Eduardo Barbosa; Moriguti, Júlio C.; Nobre, Fernando; Lima, Nereida Kilza da Costa

doi:10.1038/ajh.2012.99

Cited by 68 publications

(60 citation statements)

References 23 publications

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“…32,33 Another point that should be taken into consideration is sarcopenic obesity, which consists of increased levels of adipose tissue relating to the ageing process, regardless of BMI, with higher deposition of visceral fat and muscle infiltration. 34 Concerning the absence of association of LDL and triglycerides with the condition of pre-frailty, another Brazilian study 9 also found similar results, in which LDL (P = 0.52) and triglycerides (P = 0.65) did not present differences. A prospective investigation in Finland 35 found similar percentages, without significant differences (P = 0.45) in triglyceride and frailty levels.…”

Section: Resultssupporting

confidence: 66%

“…Cardiovascular risk factors such as BMI, low-density lipoprotein (LDL) levels, total cholesterol and triglycerides were not associated with frailty. 9 In a study carried out among hospitalized elderly people, BMI and arterial systemic hypertension were not associated with frailty syndrome. 10 Thus, the findings from studies conducted in Brazil and in other countries are contradictory, which highlights the need for more studies in this area.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, most of the investigations have assessed community-living elderly people. 2,3,[7][8][9] There is a gap in the literature with regard to the hospital context, especially for the Brazilian elderly population.…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular risk factors associated with frailty syndrome among hospitalized elderly people: a cross-sectional study

et al. 2016

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CONTEXT AND OBJECTIVE: Identification of frailty syndrome and its relationship with cardiovascular risk factors among hospitalized elderly people is important, since this may contribute towards broadening of knowledge regarding this association within tertiary-level services. This study aimed to evaluate the cardiovascular risk factors associated with frailty syndrome among hospitalized elderly people. DESIGN AND SETTING: Observational cross-sectional study in a public teaching hospital. METHODS:The participants were elderly patients admitted to clinical and surgical wards. The cardiovascular risk factors assessed were: body mass index (BMI), waist circumference, systemic arterial hypertension (SAH), blood glucose, total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL) and triglycerides. To identify frailty syndrome, the method proposed by Fried was used. The data were analyzed through descriptive statistics, chi-square test (P < 0.10) and multinomial logistic regression (P < 0.05). RESULTS: A total of 205 individuals were evaluated. It was found that 26.3% (n = 54) of the elderly people were frail, 51.7% (n = 106) were pre-frail and 22% (n = 45) were non-frail. The preliminary bivariate analysis (P < 0.10) for the regression model showed that frailty was associated with BMI (P = 0.016), LDL cholesterol (P = 0.028) and triglycerides (P = 0.093). However, in the final multivariate model, only overweight remained associated with the pre-frail condition (odds ratio, OR = 0.44; 95% confidence interval, CI = 0.20-0.98; P = 0.045). CONCLUSION: States of frailty were highly present in the hospital environment. The pre-frail condition was inversely associated with overweight. RESUMO CONTEXTO E OBJETIVO:A identificação da síndrome de fragilidade em idosos hospitalizados em interface com fatores de risco cardiovascular é relevante, pois pode contribuir para a ampliação do conhecimento sobre essa relação no nível de serviço terciário. Este estudo objetivou avaliar os fatores de risco cardiovascular associados à síndrome de fragilidade em idosos hospitalizados. TIPO DE ESTUDO E LOCAL: Estudo observacional transversal em hospital público de ensino. MÉTODOS: Participaram idosos internados nas clínicas médica e cirúrgica. Os fatores de risco cardiovascular avaliados foram: índice de massa corporal (IMC), circunferência abdominal, hipertensão arterial sistêmica (HAS), glicemia, colesterol total, lipoproteínas de alta densidade (HDL), lipoproteínas de baixa densidade (LDL) e triglicérides. Para identificar a síndrome de fragilidade, utilizou-se o método proposto por Fried. Os dados foram analisados por estatística descritiva, teste qui-quadrado (P < 0,10) e regressão logística multinomial (P < 0,05). RESULTADOS: Foram incluídos 205 indivíduos. Constatou-se que 26,3% (n = 54) dos idosos eram frágeis, 51,7% (n = 106) pré-frágeis e 22% (n = 45) não frágeis. A análise bivariada preliminar (P < 0,10) para o modelo de regressão indicou associações da fragilidade com as variáveis IMC (P = 0,016), col...

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Section: Resultssupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

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Cardiovascular risk factors associated with frailty syndrome among hospitalized elderly people: a cross-sectional study

et al. 2016

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“…The prevalence of the criteria varies according to the population studied, although weakness characterized by low handgrip strength has been the most prevalent criterion in many studies, underscoring the importance of muscle strength in the genesis of the syndrome. [27][28][29] In an investigation on the early manifestations and development of frailty phenotype in women, Xue et al reported that the incidence of frailty among women who were non-frail at the beginning of the study was 9%. 29 Despite the heterogeneity observed, weakness was the most common initial manifestation and its occurrence together with slowness and low physical activity preceded exhaustion and weight loss in 76% of the women who were not frail at the beginning of the study.…”

Section: And 87% In Belomentioning

confidence: 99%

Frailty syndrome in an independent urban population in Brazil (FIBRA study): a cross-sectional populational study

et al. 2016

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CONTEXT AND OBJECTIVE: Frailty is a multifactorial syndrome. The aim of this study was to determine the prevalence and characteristics of frailty syndrome in an elderly urban population. DESIGN AND SETTING: Cross-sectional study carried out at the homes of a randomized sample representing the independent elderly individuals of Ribeirão Preto, Brazil. METHODS: Sociodemographic characteristics, clinical data and criteria of the frailty phenotype were obtained at the subjects' homes; 385 individuals were evaluated. Frailty was defined based on detection of weight loss, exhaustion, weakness, slowness and low physical activity level. Individuals with three or more of these characteristics were classified as frail and those with one or two as pre-frail. Specific cutoff points for weakness, slowness and low physical activity level were calculated. RESULTS: The participants' mean age was 73.9 ± 6.5 years, and 64.7% were women. 12.5% had lost weight over the last year; 20.5% showed exhaustion, 17.1% slowness, 24.4% low physical activity level and 20.5% weakness. 9.1% were considered frail and 49.6% pre-frail. Frail subjects were older, attended more medical visits, had a higher chance of hospitalization within the last 12 months and had more cerebrovascular events, diabetes, neoplasms, osteoporosis and urinary and fecal incontinence. CONCLUSION: In this independent elderly population, there were numerous frail and pre-frail individuals. Frailty syndrome was associated with high morbidity. Cutoff points for weakness, slowness and low physical activity level should be adjusted for the population under study. It is essential to identify frail and pre-frail older individuals for appropriate interventions. RESUMO

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“…Another issue requiring clarification is the effectiveness of interventions in terms of drug prescription and changes in analytical parameters. 25,26 The focus of attention should also be directed to economic data, namely, costs relative to benefits and/or savings associated with implementing the interventions for pre-frailty and frailty. 27 A preliminary search of the JBI Database of Systematic Reviews and Implementation Reports, the Cochrane Database of Systematic Reviews, Prospero, CINAHL, and Medline has revealed that there are currently no systematic review (neither published nor in progress) on clinical/medical and economic effectiveness of interventions to prevent or reduce frailty in older adults.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the interventions in preventing the progression of pre-frailty and frailty in older adults: a systematic review protocol

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Bobrowicz-Campos

et al. 2016

JBI Database of Systematic Reviews and Implementation Reports

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Association of Frailty Syndrome in the Elderly With Higher Blood Pressure and Other Cardiovascular Risk Factors

Abstract: Subjects with frailty syndrome had higher BP evaluated by ABPM and other cardiovascular risk factors such as lower HDL and more abdominal fat than nonfrailty group.

Cited by 68 publications

References 23 publications

Cardiovascular risk factors associated with frailty syndrome among hospitalized elderly people: a cross-sectional study

Cardiovascular risk factors associated with frailty syndrome among hospitalized elderly people: a cross-sectional study

Frailty syndrome in an independent urban population in Brazil (FIBRA study): a cross-sectional populational study

Effectiveness of the interventions in preventing the progression of pre-frailty and frailty in older adults: a systematic review protocol

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