Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES)

Iwai-Saito, Kousuke; Sato, Koryu; Aida, Jun; Kondo, Katsunori

doi:10.1186/s12877-023-03979-y

Cited by 5 publications

References 54 publications

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Association Between Frailty and Pelvic Organ Prolapse in Elderly Women: A Retrospective Study

Obinata,

Hara,

Hashimoto

et al. 2024

Int Urogynecol J

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Introduction and Hypothesis This study evaluated the association between pelvic organ prolapse (POP), frailty, and sarcopenia to explore how POP treatment can extend healthy life expectancy in elderly women. Methods We conducted a retrospective study of prospectively collected data, comparing women with mild POP (stages 0–II) with those with advanced POP (stages III and IV). The inclusion criteria for this study were women who visited the clinic with at least one symptom of pelvic floor dysfunction and underwent imaging studies between April 2020 and November 2022. Initially, 119 patients met these inclusion criteria. Patients were excluded if they had a history of previous POP treatment, did not respond to the study survey, or were lost to follow-up. After applying these exclusion criteria, 82 patients were included in the final analysis, of whom 65 underwent surgery (laparoscopic sacrocolpopexy, colpocleisis, tension-free vaginal tape, and native tissue repair). Assessments included POP Quantification, Kihon Checklist, Pelvic Organ Prolapse Quality of Life (P-QOL) questionnaire, International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), and Incontinence Symptom Questionnaire (ICIQ-SF). Pelvic muscles were measured using MRI or CT. Immunohistochemical analysis of estrogen receptor alpha (ERα), estrogen receptor beta , and androgen receptor was performed on surgical specimens from 43 patients. Results The median age of participants was 75 years. Of the 82 patients, 48 (58.5%) were classified as frail or pre-frail, and 22 (26.8%) exhibited motor impairment. Advanced POP (stages 3 and 4) was seen in 41 patients. These patients had more motor function impairments (advanced, 16; mild, 6; p = 0.01). Patients with advanced POP had poorer P-QOL, ICIQ-SF (median: 9.5 vs 4, p = 0.006) and OABSS (7 vs 4, p = 0.008) scores, and smaller pubococcygeus muscle diameter (2.5 vs 3 cm, p = 0.017). Postoperatively, significant improvements were seen in P-QOL (all domains except personal relationships: p < 0.001), total IPSS (11 vs 4, p < 0.001), OABSS (6 vs 5, p = 0.033), and ICIQ-SF scores (6 vs 2, p < 0.001). ERα expression was associated with preoperative frailty (r = −0.37, p = 0.014). Conclusions Advanced POP correlates with poorer QOL, worse urinary symptoms, and reduced pubococcygeus muscle diameter, consistent with sarcopenia, compared with mild POP.

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Association Between Frailty and Pelvic Organ Prolapse in Elderly Women: A Retrospective Study

Obinata,

Hara,

Hashimoto

et al. 2024

Int Urogynecol J

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Excess Mortality and Hospitalizations Associated With Seasonal Influenza in Patients With Heart Failure

Modin,

Claggett,

Johansen

et al. 2024

Journal of the American College of Cardiology

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Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk

Lee,

Zuo,

Steiling

et al. 2024

PLoS ONE

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Background Chronic inflammation may increase susceptibility to pneumonia. Research question To explore associations between clinical comorbidities, serum protein immunoassays, and long-term pneumonia risk. Methods Framingham Heart Study Offspring Cohort participants ≥65 years were linked to their Centers for Medicare Services claims data. Clinical data and 88 serum protein immunoassays were evaluated for associations with 10-year incident pneumonia risk using Fine-Gray models for competing risks of death and least absolute shrinkage and selection operators for covariate selection. Results We identified 1,370 participants with immunoassays and linkage to Medicare data. During 10 years of follow up, 428 (31%) participants had a pneumonia diagnosis. Chronic pulmonary disease [subdistribution hazard ratio (SHR) 1.87; 95% confidence interval (CI), 1.33–2.61], current smoking (SHR 1.79, CI 1.31–2.45), heart failure (SHR 1.74, CI 1.10–2.74), atrial fibrillation/flutter (SHR 1.43, CI 1.06–1.93), diabetes (SHR 1.36, CI 1.05–1.75), hospitalization within one year (SHR 1.34, CI 1.09–1.65), and age (SHR 1.06 per year, CI 1.04–1.08) were associated with pneumonia. Three baseline serum protein measurements were associated with pneumonia risk independent of measured clinical factors: growth differentiation factor 15 (SHR 1.32; CI 1.02–1.69), C-reactive protein (SHR 1.16, CI 1.06–1.27) and matrix metallopeptidase 8 (SHR 1.14, CI 1.01–1.30). Addition of C-reactive protein to the clinical model improved prediction (Akaike information criterion 4950 from 4960; C-statistic of 0.64 from 0.62). Conclusions Clinical comorbidities and serum immunoassays were predictive of pneumonia risk. C-reactive protein, a routinely-available measure of inflammation, modestly improved pneumonia risk prediction over clinical factors. Our findings support the hypothesis that prior inflammation may increase the risk of pneumonia.

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Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES)

Cited by 5 publications

References 54 publications

Association Between Frailty and Pelvic Organ Prolapse in Elderly Women: A Retrospective Study

Association Between Frailty and Pelvic Organ Prolapse in Elderly Women: A Retrospective Study

Excess Mortality and Hospitalizations Associated With Seasonal Influenza in Patients With Heart Failure

Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk

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