Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study

Rando, Kenneth; Hong, Kwangik; Bhagwagar, Zubin; Li, Chiang‐Shan R.; Bergquist, Keri; Guarnaccia, Joseph; Sinha, Rajita

doi:10.1176/appi.ajp.2010.10020233

Cited by 172 publications

(153 citation statements)

References 64 publications

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“…Moreover, we showed that this inability relies on two cumulative impairments: (a) reduced frontal activations (VPFC-MFG) during ostracism, which is in line with previous studies determining anatomical and functional frontal alterations in alcohol-dependence (Bühler and Mann, 2011). It has recently been shown that the extent of these frontal alterations is correlated with higher relapse probability (Rando et al, 2011). As social disturbances are highly involved in relapse (Zywiak et al, 2003;Uekermann and Daum, 2008), our results suggest that this link between frontal alterations and relapse could be partly due to this inability to regulate social problems when frontal areas are damaged; (b) altered frontocingulate functional connectivity.…”

Section: Discussionsupporting

confidence: 91%

Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Maurage

Joassin

Philippot

et al. 2013

Neurophysiologie Clinique/Clinical Neurophysiology

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Alcohol-dependence is associated with cognitive and biological alterations, and also with interpersonal impairments. Although overwhelming in clinical settings and involved in relapse, these social impairments have received little attention from researchers. Particularly, brain alterations related to social exclusion have not been explored in alcohol-dependence. Our primary purpose was to determine the neural correlates of social exclusion feelings in this population. In all, 44 participants (22 abstinent alcohol-dependent patients and 22 paired controls) played a virtual game ('cyberball') during fMRI recording. They were first included by other players, then excluded, and finally re-included. Brain areas involved in social exclusion were identified and the functional connectivity between these areas was explored using psycho-physiological interactions (PPI). Results showed that while both groups presented dorsal anterior cingulate cortex (dACC) activations during social exclusion, alcohol-dependent participants exhibited increased insula and reduced frontal activations (in ventrolateral prefrontal cortex) as compared with controls. Alcohol-dependence was also associated with persistent dACC and parahippocampal gyrus activations in re-inclusion. PPI analyses showed reduced frontocingulate connectivity during social exclusion in alcohol-dependence. Alcohol-dependence is thus linked with increased activation in areas eliciting social exclusion feelings (dACC-insula), and with impaired ability to inhibit these feelings (indexed by reduced frontal activations). Altered frontal regulation thus appears implied in the interpersonal alterations observed in alcohol-dependence, which seem reinforced by impaired frontocingulate connectivity. This first exploration of the neural correlates of interpersonal problems in alcohol-dependence could initiate the development of a social neuroscience of addictive states.

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Section: Discussionsupporting

confidence: 91%

Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Maurage

Joassin

Philippot

et al. 2013

Neurophysiologie Clinique/Clinical Neurophysiology

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“…In the evaluation of sex-specific differences, an age-matched comparison within each age group may be important. Like many studies, our study found that the frontal cortex and periventricular regions were more atrophic in men than in women, possibly because of a greater degree of alcohol intake in men (21). In fact, according to their interview sheets, men drank more alcohol than women in their daily lives (66.7% vs. 24.0%).…”

Section: Discussionsupporting

confidence: 73%

Age-Related Sex-Specific Changes in Brain Metabolism and Morphology

et al. 2015

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With a large database, we aimed to evaluate sex-specific distinctive changes in brain glucose metabolism and morphology during normal aging using MRI and 18 F-FDG PET. Methods: A total of 963 cognitively healthy adults were included in this study. All subjects completed a medical questionnaire, took the mini-mental state examination, and underwent brain MRI and whole-body 18 F-FDG PET. The MR and PET images were statistically analyzed using 3-dimensional stereotactic surface projection. All images were corrected for whole-brain pixel value to identify the brain regions with significant changes, and regions of interest were set up with reference to Brodmann areas. We evaluated morphologic and glucose metabolic changes by cross-sectional analysis. The baseline database consisted of subjects from 30 to 40 y old, and the age-step for comparison was 5-y ranges. We also compared sex-specific differences in MR and PET images in each age group. Results: Regarding age-related changes, in both sexes brain atrophy was observed in the lateral frontal and parietal regions and glucose hypometabolism in the medial frontal regions. There were significant differences in these parameters between the sexes; parallel changes in volume and metabolism were manifested in the medial frontal cortex in men and in the lateral and medial temporal cortex in women. By contrast, metabolism-dominant reductions were manifested in the lateral and medial parietal cortex in men and in the ventrolateral prefrontal cortex, including the Broca area, in women. These differences became insignificant in individuals 66 y or older. Conclusion: Our brain mapping study with a large number of reference human brain data demonstrated age-related parallel changes between morphology and metabolism in the medial frontal regions and sex-specific hypometabolism in the parietal (male) and ventrolateral prefrontal (female) cortices. These findings may suggest an aging vulnerability in sex-specific brain regions: the parietal cortex for visuospatial ability in men and the Broca area for speech processing in women. The current trend of an increase in the number of dementia patients, including those with Alzheimer disease (AD) (1), as well as the revised criteria for the diagnosis of dementia by the National Institute on Aging and the Alzheimer's Association (2-5), has brought researchers to place greater attention on early, preclinical, detection of changes in brain physiology. Indeed, in familial AD, pathologic changes in the brain seem to develop 25 y before the onset of clinical symptoms (6).To detect the preclinical stage of AD, it is necessary to catch subtle deviations from the healthy brain and, thus, to know the morphology and activity of a healthy brain for comparison. Several studies have used MRI or PET on cognitively normal people to evaluate age-related changes and sex-specific differences in the brain. To the best of our knowledge, however, the sexspecific differences in brain morphology and metabolism found by previous brain imaging studies were only in ...

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“…1,5,[20][21][22] Brain function in alcohol-dependent patients may be affected by brain atrophy in cortical and subcortical regions, which has also been associated with the prospective relapse risk 23 (for review, see Sullivan 24 ). Rando et al 25 demonstrated that gray matter volume deficits in medial frontal and posterior parietal-occipital brain regions are predictive of an earlier return to alcohol use in detoxified alcohol-dependent patients. Wrase et al 23 and Benegal et al 26 observed reduced volumes of the cingulate and parahippocampal gyri, as well as the amygdala, in subsequent relapsers and, interestingly, also in young, alcohol-naive subjects at high risk for alcohol dependence due to a positive family history.…”

mentioning

confidence: 99%

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

Beck

Wüstenberg

Genauck

et al. 2012

Arch Gen Psychiatry

253

242

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Context:In alcohol-dependent patients, brain atrophy and functional brain activation elicited by alcohol-associated stimuli may predict relapse. However, to date, the interaction between both factors has not been studied.Objective: To determine whether results from structural and functional magnetic resonance imaging are associated with relapse in detoxified alcohol-dependent patients.Design: A cue-reactivity functional magnetic resonance experiment with alcohol-associated and neutral stimuli. After a follow-up period of 3 months, the group of 46 detoxified alcohol-dependent patients was subdivided into 16 abstainers and 30 relapsers. Participants: A total of 46 detoxified alcoholdependent patients and 46 age-and sex-matched healthy control subjects Main Outcome Measures: Local gray matter volume, local stimulus-related functional magnetic resonance imaging activation, joint analyses of structural and functional data with Biological Parametric Mapping, and connectivity analyses adopting the psychophysiological interaction approach.Results: Subsequent relapsers showed pronounced atrophy in the bilateral orbitofrontal cortex and in the right medial prefrontal and anterior cingulate cortex, compared with healthy controls and patients who remained abstinent. The local gray matter volume-corrected brain response elicited by alcohol-associated vs neutral stimuli in the left medial prefrontal cortex was enhanced for subsequent relapsers, whereas abstainers displayed an increased neural response in the midbrain (the ventral tegmental area extending into the subthalamic nucleus) and ventral striatum. For alcohol-associated vs neutral stimuli in abstainers compared with relapsers, the analyses of the psychophysiological interaction showed a stronger functional connectivity between the midbrain and the left amygdala and between the midbrain and the left orbitofrontal cortex.Conclusions: Subsequent relapsers displayed increased brain atrophy in brain areas associated with error monitoring and behavioral control. Correcting for gray matter reductions, we found that, in these patients, alcohol-related cues elicited increased activation in brain areas associated with attentional bias toward these cues and that, in patients who remained abstinent, increased activation and connectivity were observed in brain areas associated with processing of salient or aversive stimuli. Psychiatry. 2012;69(8):842-853 Arch Gen

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Association of Frontal and Posterior Cortical Gray Matter Volume With Time to Alcohol Relapse: A Prospective Study

Cited by 172 publications

References 64 publications

Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Disrupted regulation of social exclusion in alcohol-dependence: An FMRI study

Age-Related Sex-Specific Changes in Brain Metabolism and Morphology

Effect of Brain Structure, Brain Function, and Brain Connectivity on Relapse in Alcohol-Dependent Patients

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