Association of FSH With Metabolic Syndrome in Postmenopausal Women: A Comparison With CRP, Adiponectin and Leptin

Stefańska, Anna; Ponikowska, Irena; Cwiklinska-Jurkowska, Malgorzata; Sypniewska, Grażyna

doi:10.2217/bmm.14.49

Cited by 30 publications

(52 citation statements)

References 31 publications

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“…There is likely to be a bidirectional relationship between the progression to non‐alcoholic steatohepatitis and the development of diabetes and obesity . Additionally, recent studies demonstrated that FSH is significantly associated with metabolic factors . Every 1 standard deviation decrement of FSH is associated with a 3.83‐fold increased risk of metabolic syndrome .…”

Section: Discussionmentioning

confidence: 99%

“…9 Additionally, recent studies demonstrated that FSH is significantly associated with metabolic factors. [13][14][15][16] Every 1 standard deviation decrement of FSH is associated with a 3.83-fold increased risk of metabolic syndrome. 15 In the current study, FSH was significantly correlated with metabolic syndrome components.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16] Every 1 standard deviation decrement of FSH is associated with a 3.83-fold increased risk of metabolic syndrome. 15 In the current study, FSH was significantly correlated with metabolic syndrome components. Thus, our finding of the association between FSH and NAFLD is reasonable and adds new evidence to the innovative role of FSH in metabolic disorders in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

“…14 Two recent studies also reported that lower FSH was significantly associated with metabolic syndrome in postmenopausal women. 15,16 Therefore, we hypothesized that FSH might be associated with NAFLD in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

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Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old

Wang

Qin

Han

et al. 2016

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old

Wang

Qin

Han

et al. 2016

J of Gastro and Hepatol

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show abstract

“…A higher FSH level was shown to be associated with an increase in frequencies of hot flashes and night sweats (2) and with an increase in subclinical atherosclerosis progression in women at midlife (3). On the other hand, low FSH levels were shown to be significantly associated with diabetes (4), metabolic syndrome (5) and non-alcoholic fatty liver disease in postmenopausal women (6).…”

Section: Introductionmentioning

confidence: 99%

Variation of urinary follicle-stimulating hormone level after menopause : From the results of Japan Nurses’ Health Study

et al. 2019

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The change in follicle-stimulating hormone (FSH) during the menopausal transition and associations of FSH with various diseases have been assessed by using blood samples. We examined cross-sectionally the variation of FSH levels, associations of estrone and estradiol with FSH, and associations of BMI with these hormones by using urinary samples from peri-and postmenopausal women in Japan. Of 4472 participants in the Urinary Isoflavone Concentration Survey of the Japan Nurses' Health Study, we analyzed urinary levels of estrone, estradiol and FSH in 547 women aged from 45 to 54 years. Urinary FSH levels varied widely in postmenopausal women and the pattern of change in urinary FSH levels seems to be similar to that in blood FSH levels in previous studies. There were no significant differences in age, body mass index (BMI), estradiol, estrone and estradiol/ estrone ratio among three groups according to the tertile of FSH. In postmenopausal women, there were significant associations of BMI with levels of estrone and estradiol, but there was no significant association of BMI with FSH. Studies using urinary samples will allow us to establish a study project as a large-scale population-based study to determine associations between FSH and various diseases after menopause.

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Follicle-stimulating hormone associates with prediabetes and diabetes in postmenopausal women

et al. 2015

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AimsNo study explores the association between follicle-stimulating hormone (FSH) and glucose metabolism in general women. We aim to investigate whether the variation of FSH is associated with prediabetes and diabetes in postmenopausal women.MethodsOur data were from survey on prevalence in East China for metabolic diseases and risk factors in 2014. Thousand six hundred and ten postmenopausal women at the age of 55–89 who were not using hormone replacement therapy were selected. Prediabetes and diabetes were defined according to American Diabetes Association 2014 criteria. FSH, luteinizing hormone, total testosterone and estradiol were measured by chemiluminescence. Multinomial logistic analyses were used for the association of FSH with prediabetes and diabetes, and linear regression for the association of FSH with fasting plasma glucose (FPG) and HbA1c.ResultsAmong the participants, 778 (48.3 %) had prediabetes and 121 (7.5 %) had newly diagnosed diabetes. In linear regression, after full adjustment for demographic variables, metabolic factors, E2 and LH, FSH was associated with FPG and HbA1c (P < 0.05). In logistic regression, increased quartiles of FSH were associated with significantly decreased odds ratios of prediabetes and diabetes (P for trend <0.01). This association was attenuated by waist circumference and HOMA-IR, but persisted in fully adjusted model (P for trend <0.05) in which, for the lowest compared with the highest quartile of FSH, the odds ratios of prediabetes and diabetes were 1.93 (95 % CI 1.21–3.08; P < 0.01) and 3.02 (95 % CI 1.10–8.31; P < 0.05), respectively.ConclusionsLow FSH was associated with prediabetes and diabetes in postmenopausal women. The associations might be partially explained by adiposity and insulin resistance.

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Association of FSH With Metabolic Syndrome in Postmenopausal Women: A Comparison With CRP, Adiponectin and Leptin

Abstract: Our results suggest that the FSH concentration assesses the probability of MetS similarly to L/A or adiponectin and better than CRP or leptin in postmenopausal women.

Cited by 30 publications

References 31 publications

Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old

Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old

Variation of urinary follicle-stimulating hormone level after menopause : From the results of Japan Nurses’ Health Study

Follicle-stimulating hormone associates with prediabetes and diabetes in postmenopausal women

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