Association of G1359A polymorphism of the cannabinoid receptor gene (<scp>CNR</scp>1) with macronutrient intakes in obese females

Luis, Daniel Antonio de; Izaola, Olatz; Aller, R.; López, Juan José; Torres, Beatriz; Dí­az, Gonzalo; Gómez, E. Tamayo; Romero, Enrique

doi:10.1111/jhn.12298

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…The effect of diet on human health and disease is affected by different genetic backgrounds (10,11) . As far as we know, few studies have been designed aiming to explore the effect of rs16147 on metabolic response and weight change after a dietary intervention.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines

Luis

Izaola

Fuente

et al. 2016

J Human Nutrition Diet

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Section: Introductionmentioning

confidence: 99%

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines

Luis

Izaola

Fuente

et al. 2016

J Human Nutrition Diet

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“…Mutant allele associated with lower insulin. Mutant allele with lower BMI Mutant allele with lower HOMA IR , TGs …”

Section: Resultsmentioning

confidence: 99%

“…Overall, 22 positive associations with lipid levels were seen. The mutant allele of CB 1 SNP rs1049353 was associated with higher HDL and lower TGs in three cohorts, as well as with lower TGs in two populations (n = 808) (Table ).…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Doris

Millar

Idris

et al. 2018

Diabetes Obesity Metabolism

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The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to adiposity and glucose metabolism. Database searches identified 734 articles, of which 65 were included; these covered 70 SNPs in genes coding for cannabinoid receptors 1 and 2 (CB , CB ), fatty acid amide hydrolase (FAAH) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD). No studies included SNPs relating to monoacylglycerol lipase or diacylglycerol lipase. The CB receptor SNP rs1049353 showed 17 associations with lower body mass index (BMI) and fat mass (five studies). It also showed three associations with lower insulin levels (one study). Conversely, the CB receptor SNP rs806368 was associated with increased BMI and waist circumference (two studies). The FAAH SNP rs324420 was associated with increased obesity (three studies). A haplotype of NAPE-PLD was associated with decreased BMI (one study). A total of 60 SNPs showed no association with any measured outcome. This review suggests a complex but important role of ECS SNPs in energy and glucose metabolism.

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“…This poses the following question: what is the reason for such correlation? Do people with allele G consume more food, as some studies show [20], therefore absorbing more arsenic and resulting in a higher arsenic concentration? Or, on the other hand, does a greater amount of fat tissue enable a higher arsenic concentration?…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead

Matys

Szymańska–Chabowska

Bogunia‐Kubik

et al. 2020

JCM

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The purpose of this work was to assess the influence of selected CNR1, MC4R, LEP, FTO and VDR FOKI gene polymorphisms on blood and urine concentration markers of lead, cadmium and arsenic in a population directly exposed to these metals. Eighty-five people exposed to lead, arsenic and cadmium were qualified to take part in the study. Standard urine samples and 25 mL of venous blood from each worker were collected to assay basic laboratory and toxicological markers as well as selected single nucleotide polymorphisms (SNPs) within CNR1-cannabinoid receptor 1 gene (rs806368, rs806381, rs1049353, rs12720071), MC4R-melanocortin 4 receptor gene (rs17782313), LEP-leptin promoter gene (rs7799039), FTO-alpha-ketoglutarate-dependent dioxygenase gene (rs9939609) and VDR-vitamin D receptor (rs10735810) genes. It appeared that, except for the MC4R SNP, all the other polymorphisms were found to be associated with various laboratory parameters. Arsenic concentration in urine was associated with all four CNR1 and LEP SNPs, while cadmium concentration in blood was affected by the VDR polymorphism. Moreover, some significant relationships were also observed between CNR1 rs1049353 and FTO rs9939609 gene variants and markers of lead exposure. These results imply SNPs within genes coding for proteins involved in development of metabolic syndrome may be of prognostic value for persons directly exposed to lead, cadmium and arsenic.

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Association of G1359A polymorphism of the cannabinoid receptor gene (CNR1) with macronutrient intakes in obese females

Abstract: The present study reports an association of the A allele with a better lipid profile (triglycerides and HDL cholesterol) than non-A allele carriers. In addition, this polymorphism is associated with a specific macronutrient intake, as well as with low cholesterol and fat saturated intakes.

Cited by 12 publications

References 19 publications

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines

Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

The Relationship between Selected CNR1, MC4R, LEP, FTO and VDR Gene Polymorphisms and Several Basic Toxicological Parameters Among Persons Occupationally Exposed to Arsenic, Cadmium and Lead

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