Association of gastric cancer and nephrotic syndrome. An immunologic study in three patients

Wakashin, M; Wakashin, Y; Iesato, K; Ueda, Shiro; Mori, Yoshihide; Tsuchida, H; Shigematsu, Hidekazu; Okuda, Kunio

doi:10.1016/0016-5085(80)90679-4

Cited by 49 publications

(12 citation statements)

References 19 publications

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“…[23,24] It is now believed that an underlying malignancy is responsible for up to 5 -10% of cases of MN in adults (5.4% in our study), with the risk being highest in patients over 60. Nevertheless, several observations considerably support this association, especially with observed remissions of the proteinuria after the removal of the tumor and its reappearance with tumor recurrence.…”

Section: Discussionmentioning

confidence: 49%

Secondary Membranous Nephropathy - One Center Experience

Rihova¹,

Honsová²,

Merta³

et al. 2005

LRNF

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Section: Discussionmentioning

confidence: 49%

Secondary Membranous Nephropathy - One Center Experience

Rihova¹,

Honsová²,

Merta³

et al. 2005

LRNF

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“…Some reports have described the resolution of proteinuria after therapy for complicating neoplasms or infected virus in patients with MN [13,18,23], and a causal relationship between these diseases and renal abnormality is strongly suggested. However, in most patients with MN there are no proven underlying conditions and the disease is diagnosed as idiopathic.…”

Section: Introductionmentioning

confidence: 96%

Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy

et al. 1997

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Renal biopsy specimens from patients with membranous nephropathy (MN) were studied using immunohistochemical labelling to clarify the aetiological significance of Helicobacter pylori antigen in this disease. Sixteen specimens were examined, from 7 male and 9 female MN patients. Renal specimens from patients with diabetic nephropathy and IgA nephropathy, and from autopsied patients without renal diseases were obtained as controls. Immunohistochemical labelling was performed using one polyclonal antibody and three monoclonal antibodies against H. pylori. Specimens from 11 of the MN patients revealed granular deposits along the glomerular capillary walls, which reacted positively with polyclonal antibody after trypsin pretreatment. None of the control specimens revealed positive labelling. The MN specimens showed no positive reaction with the primary antibody, which had been treated for immunoabsorption testing using sonicated H. pylori. We also determined H. pylori status in these MN patients histologically and/or serologically. Of the 11 patients whose glomeruli were positive for anti-H. pylori antibody, 7 were suitable for analysis, and all were regarded as positive for H. pylori infection. These results suggest that the presence of a specific antigen in the glomeruli of patients with MN and H. pylori infection may be involved in the pathogenesis of MN.

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“…Paraneoplastic membranous nephropathy is thought to be mediated by subepithelial immune complexes of tumor antigens and antibodies. Some studies have shown that, in patients with membranous nephropathy and colorectal cancer, carcinoembryonic antigen (CEA) can be detected in the glomeruli [5,6]; however, other studies have shown that such an association is not clear [7,8]. In our patient, such markers were not measured before treatment, but it would have been unlikely that they would have been elevated in such early stage small cancers.…”

Section: Discussionmentioning

confidence: 57%

Clinical improvement of membranous nephropathy after endoscopic resection of double early gastrointestinal cancers

et al. 2010

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A-52-year-old man presented to our hospital with nephrotic syndrome caused by membranous nephropathy. Early gastric adenocarcinoma confined to the submucosa, and well-differentiated adenocarcinoma in a sigmoid adenoma were detected by screening endoscopy. Two years after complete endoscopic resection of these tumors, the estimated 24-h urinary protein excretion decreased, and serum total protein and albumin returned to their normal levels although he had no immunosuppressive therapy. Thus, this case was considered to be a case of secondary membranous nephropathy to cancer, although whether the pathogenesis was due to circulating or in situ immune complexes is unknown. The suspected antigen component of this immune complex can include carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). In our patient, however, serum CEA and CA19-9 were within normal values during the clinical course, and detected cancers were early stage and very small. Recently, the existence of anti-mucin 1 (MUC1) antibodies before carcinogenesis and their usefulness for early detection of cancer were reported. We tried to stain tumors and glomeruli for MUC1 but, although we had positive findings in both tumors but not in glomeruli, the role of MUC1 in the pathogenesis of membranous nephropathy is unknown. To the best of our knowledge, paraneoplastic nephrosis caused by double early cancers expressing MUC1 in the gastrointestinal tract has not been previously reported.

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Association of gastric cancer and nephrotic syndrome. An immunologic study in three patients

Cited by 49 publications

References 19 publications

Secondary Membranous Nephropathy - One Center Experience

Secondary Membranous Nephropathy - One Center Experience

Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy

Clinical improvement of membranous nephropathy after endoscopic resection of double early gastrointestinal cancers

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