Association of gastrointestinal events and osteoporosis treatment initiation in newly diagnosed osteoporotic Israeli women

Yu, Jingbo; Goldshtein, Inbal; Shalev, Varda; Chodick, Gabriel; Ish‐Shalom, Sophia; Sharon, Orli; Modi, Ankita

doi:10.1111/ijcp.12676

Cited by 6 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MHS is a fully computerized organization. Information including patient records, billing systems, pharmaceutical dispensations, and chronic disease registries is housed in the organization’s central electronic warehouse DATA BASE These automated datasets have been previously described at length in previous studies [ 9 – 12 ]. During the physician/nurse patient encounter, all of the information collected is recorded electronically in either coded or free text fields.…”

Section: Introductionmentioning

confidence: 99%

Family history intake: a challenge to personalized approaches in health promotion and disease prevention

Endevelt

Goren

Sela

et al. 2015

Isr J Health Policy Res

View full text Add to dashboard Cite

BackgroundFamily history is considered an essential, obligatory part of the primary physician’s intake interview. Including coded FH in a unified medical file can save expensive genetic tests and detect the early onset of diseases in young people who are not recommended to be screened routinely. The objectives of this study are to explore the frequency and point in time of recording the coded family history (FH) as a first step to increasing awareness of the importance of such information.MethodsAll ICD-9 coded diagnoses of familial histories of disease (ICD-9 coded V16.0 – V19.8), including diseases related to gender, age, and indications of chronic diseases, were collected from the electronic medical records of patients ages 18 and above in Israel’s Maccabi Health Care system. The study was carried out in 2012 on the basis of coded data for 1.9 million Maccabi members, which were collected from 2004 through 2011.ResultsOf the Maccabi members (the second biggest HMO in Israel covering 2 million people), only 10 % had FH coded documentation. FH was significantly more frequent for females than for males (13.5 % vise 10.1 %) and increased with age. About 10 % of the FH documentation occurred before any disease was diagnosed. The most frequent FH documentation was observed for cardiovascular disease, hypertension, and diabetes. In the case of cancer FH was more frequent in females, whereas in the case of males it was cardiovascular disease.DiscussionFamily history is an easy tool and need to be coded and implimented in most visits in order to get the best information of the potential health and disease of the patients.ConclusionsFH frequency is very low and varies with gender and age. The literature suggests that implementing it routinely in primary care will improve health care. Further research is needed to identify the factors that impede primary care givers from complying with FH guidelines.

show abstract

Section: Introductionmentioning

confidence: 99%

Family history intake: a challenge to personalized approaches in health promotion and disease prevention

Endevelt

Goren

Sela

et al. 2015

Isr J Health Policy Res

View full text Add to dashboard Cite

show abstract

“…This is not without precedent: a Swedish study using data from 2001-2004 found that those with dementia were less likely to receive OP medications than those without dementia, after adjusting for other factors 35 . The potential for side-effects has been cited as a barrier to OP treatment 26 , and the occurrence of GI events, specifically, has been shown to reduce the likelihood of receiving any OP treatment 20,36 , as well as the likelihood of being treated with a BP versus a non-BP 25 . In the current study, baseline GI events were associated with increased odds of OP treatment during follow-up.…”

Section: Discussionmentioning

confidence: 99%

High rate of non-treatment among osteoporotic women enrolled in a US Medicare plan

Yang

Sajjan

Modi

2016

Current Medical Research and Opinion

View full text Add to dashboard Cite

Objective: To estimate the rate of non-treatment among elderly women with osteoporosis (OP) and to examine the association between patient characteristics and receiving treatment. Research design and methods: This cross-sectional, retrospective, observational study utilized patient information and claims from the Humana database to identify Medicare covered women aged 65 years old and continuously enrolled with evidence of either an OP diagnosis or an OP-related fracture during 2007-2011. The main outcome was receipt of pharmacological treatment of OP during 2012 (follow-up). The percentage of non-treatment was calculated and a stepwise selection logistic regression model was employed to estimate the association between baseline demographic and clinical characteristics and receiving treatment. Results: A total of 109,829 patients were included. Mean age was 75.7 years and 79.4% were identified with OP through OP diagnosis codes and did not have evidence of a prior fracture. Approximately one-third (32%) of patients had used OP medications during the baseline period, and 39% had experienced at least one gastro-intestinal event during baseline. Among all patients, 71.4% did not receive OP therapy during follow-up. The strongest factor associated with receiving treatment was prior use of OP therapy (odds ratio [OR] ¼ 31.3; p < .001). Among the subgroup of patients with baseline fractures, 75.9% did not receive OP therapy during follow-up and the strongest factor associated with receiving treatment remained prior use of OP therapy (OR ¼ 20.4; p < .001). Those with high comorbidity burden were less likely to receive treatment in both the overall cohort and within the subgroup with baseline fractures. Conclusions: Among Medicare-eligible women aged 65 identified with OP between 2007 and 2011, 71.4% did not receive OP treatment during 2012, including 75.9% of the subgroup of patients with a prior fracture. The use of diagnosis and procedures codes to identify patients with osteoporosis is subject to variation in coding.ARTICLE HISTORY

show abstract

“…Although our study sample represented older women, the association between post-diagnosis GI events and reduced odds of treatment initiation that we observed complement previous findings in younger patients. In a study of Israeli women (mean age 65 years), which used methodology comparable to ours, Yu and colleagues observed that a post-diagnosis GI event reduced the odds of treatment initiation by 85 % [ 33 ]. Among US women (mean age 66 years), post-diagnosis GI events were associated with 75 % lower likelihood of treatment initiation [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association between gastrointestinal events and osteoporosis treatment initiation in women diagnosed with osteoporosis in France: a retrospective analysis

Cortet

Modi

Tang³

et al. 2016

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundA substantial portion of women diagnosed with osteoporosis (OP) do not initiate pharmacotherapy to reduce fracture risk. In clinical practice, gastrointestinal (GI) events have been linked with OP therapy discontinuation. However, there is limited research examining GI events as barrier to treatment initiation following an OP diagnosis. The objective of this study was to examine the association between gastrointestinal (GI) events and osteoporosis (OP) treatment initiation among post-menopausal women diagnosed with osteoporosis in France.MethodsA retrospective claims analysis of the Mediplus France database during 1997 to 2010 identified women aged ≥ 55 with an OP diagnosis and without prior OP treatment (first diagnosis date was defined as the index date). GI events were identified during the 1 year pre-index and up to 1 year post-index. OP treatment initiation post-index was identified based on the presence of claims for any bisphosphonate (BIS) or non-BIS OP medication within 1 year post-index. Multivariate models (logistic regression, Cox proportional hazards regression and discrete choice) adjusted for pre-index patient characteristics were used to assess the association of pre- and post-index GI events with the likelihood of initiating OP treatment, and the type of treatment initiated (BIS vs. non-BIS).ResultsA total of 10,292 women (mean age 70.3 years) were identified; only 25 % initiated OP treatment. Post-index GI events occurred in 11.5 % of patients, and were associated with a 75.7 % lower likelihood of initiating OP treatment. Among treated patients, a discrete choice model estimated that patients with post-index GI events were 34.6 % less likely to receive BIS vs non-BIS as compared to patients without post-index GI events.ConclusionAmong women aged ≥ 55 years with an OP diagnosis, post-index GI events were associated with a lower likelihood of OP treatment initiation.Electronic supplementary materialThe online version of this article (doi:10.1186/s12891-016-1041-8) contains supplementary material, which is available to authorized users.

show abstract

Association of gastrointestinal events and osteoporosis treatment initiation in newly diagnosed osteoporotic Israeli women

Cited by 6 publications

References 30 publications

Family history intake: a challenge to personalized approaches in health promotion and disease prevention

Family history intake: a challenge to personalized approaches in health promotion and disease prevention

High rate of non-treatment among osteoporotic women enrolled in a US Medicare plan

Association between gastrointestinal events and osteoporosis treatment initiation in women diagnosed with osteoporosis in France: a retrospective analysis

Contact Info

Product

Resources

About