Association of GCK (rs1799884), GCKR (rs780094), and G6PC2 (rs560887) Gene Polymorphisms with Type 2 Diabetes among Malay Ethnics

Ansari, Neda; Ramachandran, Vasudevan; Mohamad, Nur Afiqah; Salim, Elnaz; Ismail, Patimah; Hazmi, Mohamad; Mat, Liyana Najwa Inchee

doi:10.1055/s-0042-1760384

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…It is the first step in glucose metabolism [ 12 ]. The glucokinase gene rs1799884 polymorphism is associated with an increased risk of type 2 diabetes, abnormal fasting blood glucose, gestational diabetes and dyslipidaemia [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…The gene encoding GCKR consists of 19 exons and is located on the short arm of chromosome 2 (2p23) [ 14 ]. The rs780094 polymorphism of the glucokinase regulator gene is associated with an increased risk of developing type 2 diabetes, gestational diabetes, abnormal fasting plasma glucose levels, dyslipidaemia and metabolic syndrome [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus

Dziedziejko

Safranow

Kijko-Nowak

et al. 2023

Genes

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Post-transplant diabetes mellitus (PTDM) is a common complication that occurs in kidney transplant patients, increasing the risk of infection, cardiovascular disease and loss of graft function. Currently, factors that increase the risk of this complication are being sought, among them polymorphisms in genes that regulate carbohydrate metabolism and influence pancreatic β-cell function. The aim of this study was to evaluate the association of selected polymorphisms of genes affecting carbohydrate metabolism, such as CDKAL1 rs10946398, GCK rs1799884, GCKR rs780094 and DGKB/TMEM195 rs2191349, with the development of post-transplant diabetes in kidney transplant patients. This study included 201 Caucasian patients after kidney transplantation treated with tacrolimus. An association was observed between the CDKAL1 rs10946398 gene polymorphism and PTDM. Among patients with PTDM, there was an increased prevalence of the CC genotype in the PTDM group compared to the group without PTDM. The chance of PTDM in those with the CC genotype was 2.60 times higher compared to those with the AC + AA genotypes (CC vs. AC + AA OR (95% CI): 2.60 (1.02–6.61), p = 0.040). Multivariate logistic regression analysis showed that advanced age and the CC genotype (rare homozygote) of CDKAL1 rs10946398 were risk factors for the development of PTDM at 1 year after transplantation. There was no statistically significant association between GCK rs1799884, GCKR rs780094 or DGKB/TMEM195 rs2191349 polymorphisms and the development of post-transplant diabetes mellitus in kidney transplant patients. The results of this study suggest that the CDKAL1 rs10946398 CC genotype is associated with the increased risk of PTDM development in patients after kidney graft transplantation treated with tacrolimus.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus

Dziedziejko

Safranow

Kijko-Nowak

et al. 2023

Genes

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The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy

Tan,

Lau,

Abdelalim

et al. 2024

Trends in Molecular Medicine

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Transcription Factor 7-like 2 Gene Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis

Stephen,

Devaraj,

Sivasubramanian

et al. 2023

Biomedical and Biotechnology Research Journal (BBRJ)

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The meta-analysis aimed to investigate transcription factor 7-like 2 (TCF7 L2) (rs12255372 and rs7903146) gene polymorphisms and its association with type 2 diabetes mellitus (T2DM) in a Caucasian and Asian population. The studies included in this article were obtained using online databases. We searched databases such as Scopus, Web of Science, Embase, and PubMed for case–control articles related to TCF7 L2 polymorphisms and T2DM. To determine TCF7 L2 polymorphisms are significantly associated with T2DM, Metagenyo was used to calculate the odds ratio and 95% confidence interval. A total of 15 articles were included in this meta-analysis. TCF7 L2 rs12255372 and rs7903146 gene polymorphisms were strongly related to susceptibility to T2DM in the general population, as shown by the results of a meta-analysis. Subgroup analysis showed that both Asians and Caucasians showed a statistically significant result. This meta-analysis findings supported that TCF7 L2 rs12255372 and rs7903146 gene polymorphisms to determine susceptibility with type 2 diabetes. According to the findings of this study, people with TCF7 L2 gene polymorphisms rs12255372 for allelic, recessive, dominant, and over-dominant models have been connected to T2DM; however, rs7903146 for allelic, recessive, dominant, and over-dominant models have not been associated to the disease.

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Association of GCK (rs1799884), GCKR (rs780094), and G6PC2 (rs560887) Gene Polymorphisms with Type 2 Diabetes among Malay Ethnics

Cited by 3 publications

References 29 publications

The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus

The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus

The role of glucose-6-phosphatase activity in glucose homeostasis and its potential for diabetes therapy

Transcription Factor 7-like 2 Gene Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis

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