Association of GDF-15, hs-cTnT and NT-proBNP With Coronary Artery Disease in Patients Undergoing Elective Angiography

Souaid, Tarek; Hijazi, Ziad; Barakett, Vanda; Sarkis, Antoine; Kadri, Zeina; Batra, Gorav; Lindbäck, Johan; Abdel-Massih, Tony; Azar, Rabih R.

doi:10.2217/fca-2021-0137

Future Cardiol.

2022

DOI: 10.2217/fca-2021-0137

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Association of GDF-15, hs-cTnT and NT-proBNP With Coronary Artery Disease in Patients Undergoing Elective Angiography

Tarek Souaid

Ziad Hijazi

Vanda Barakett

et al.

Abstract: Aim: This study investigated the association between plasma levels of GDF-15, hs-cTnT and NT-proBNP and the presence of coronary artery disease (CAD) in stable patients referred for elective coronary angiography. Methods: The outcome of CAD was defined as an ordinal variable with 3 levels. The association between each biomarker and the outcome was tested using the Winell and Lindbäck method. Results: In unadjusted analysis of 252 patients, GDF-15 and hs-cTnT were associated with the presence and extent of CAD.… Show more

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2024

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Cited by 2 publications

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Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation

Piayda,

Keranov,

Schulz

et al. 2024

Clin Res Cardiol

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Background Risk prediction in patients with severe, symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) remains an unsolved issue. In addition to classical risk scoring systems, novel circulating biomarkers like mid-regional pro-adrenomedullin (MR-proADM) and growth differentiation factor 15 (GDF-15) may be of value in assessing risk. Methods Consecutive patients undergoing elective transfemoral TAVI were included in this prospective observational study. Baseline information, imaging findings, blood samples, and clinical outcomes were collected. Blood levels of the classical biomarkers interleukin-6 (IL-6) and high-sensitivity C-reactive peptide (hsCRP) and of the novel biomarkers MR-proADM and GDF-15 were measured and their predictive utility for mortality assessed. Results The study cohort consisted of 92 patients undergoing TAVI. The median age was 80.7 years [IQR 77.2;83.3], and 48 (52.2%) were male. Analysis of the area under the curve (AUC) of the receiver-operating characteristics showed that the hsCRP levels discriminated poorly (AUC 0.66, 95% CI [0.52;0.8], p = 0.027), whereas all other biomarkers reached a higher level of discrimination (IL-6: AUC 0.76, 95% CI [0.66;0.86], p < 0.001; MR-proADM: AUC 0.73, 95% CI [0.61;0.85], p = 0.002; GDF-15: AUC 0.73, 95% CI [0.61;0.85], p = 0.002). Kaplan–Meier analysis in conjunction with Youden J-statistics yielded the optimal cutoff points for each biomarker to predict survival: IL-6 4.65 pg/mL, hsCRP 12.9 mg/L, MR-proADM 1.02 nmol/L, and GDF-15 2400.1 pg/mL. Conclusion Novel circulating biomarkers like MR-proADM and GDF-15 may provide additional value in predicting survival after TAVI.

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Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation

Piayda,

Keranov,

Schulz

et al. 2024

Clin Res Cardiol

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The relationship between serum levels of LOX-1, hs-cTnT, NGAL, and renal function, and their diagnostic value in patients with chronic kidney disease: a retrospective study

Chai,

Zeng,

Gong

et al. 2024

BMC Nephrol

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Background The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease progression in CKD patients. Methods A retrospective study was conducted on 108 patients with chronic kidney disease admitted to our hospital from January 2023 to December 2023. The patients were divided into the mild renal insufficiency group (51 cases) and the severe renal insufficiency group (57 cases). The differences in serum levels of LOX-1, hs-cTnT, and NGAL between the two groups were compared, and Pearson correlation analysis was used to explore the relationship between the three levels and renal function. ROC analysis was used to evaluate the predictive value of the three markers for the diagnosis of CKD. Results The levels of LOX-1, hs-cTnT, and NGAL in the mild renal insufficiency group were lower than those in the severe renal insufficiency group (P < 0.05). Correlation analysis showed that serum levels of LOX-1, hs-cTnT, and NGAL were positively correlated with the deterioration of renal function (P < 0.001), indicating a significant correlation between LOX-1, hs-cTnT, NGAL levels, and the deterioration of renal function. ROC analysis showed that the AUC of serum levels of LOX-1, hs-cTnT, and NGAL were 0.859, 0.882, and 0.841, indicating a significant predictive value for the diagnosis of chronic kidney disease. Conclusion Serum levels of LOX-1, hs-cTnT, NGAL, and related markers demonstrate a direct association with the extent of renal impairment, offering predictive capabilities for diagnosing CKD.

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Association of GDF-15, hs-cTnT and NT-proBNP With Coronary Artery Disease in Patients Undergoing Elective Angiography

Cited by 2 publications

References 35 publications

Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation

Prognostic utility of mid-regional pro-adrenomedullin and growth differentiation factor 15 in patients undergoing transfemoral transcatheter aortic valve implantation

The relationship between serum levels of LOX-1, hs-cTnT, NGAL, and renal function, and their diagnostic value in patients with chronic kidney disease: a retrospective study

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