Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women

Aung, Myint; Konoshita, Tadashi; Moodley, Jagidesa; Gathiram, P.

doi:10.1016/j.ejogrb.2017.05.011

Cited by 23 publications

(18 citation statements)

References 24 publications

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“…Ang II exerts a cardinal role in the pathogenesis of hypertension (Kobori et al, 2007 ). Many studies have reported associations between RAS and preeclampsia (Li et al, 2016 ; Aung et al, 2017 ), indicating that RAS may also play a role in the pathogenesis of preeclampsia. Although, the peripheral RAS (plasma levels of active renin, renin and Ang II) is downregulated in the DOCA preeclampsia model (Uddin et al, 2010 ); the association of gene polymorphisms of RAS and preeclampsia was observed in human, moreover, T allele of angiotensinogen may involve in the pathogenesis of PE (Aung et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported associations between RAS and preeclampsia (Li et al, 2016 ; Aung et al, 2017 ), indicating that RAS may also play a role in the pathogenesis of preeclampsia. Although, the peripheral RAS (plasma levels of active renin, renin and Ang II) is downregulated in the DOCA preeclampsia model (Uddin et al, 2010 ); the association of gene polymorphisms of RAS and preeclampsia was observed in human, moreover, T allele of angiotensinogen may involve in the pathogenesis of PE (Aung et al, 2017 ). During pregnancy, an increase in extracellular fluid volume occurs, which reaches a 40–50% increase by the end of gestation (Scott, 1972 ; Gallery and Brown, 1987 ).…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia

et al. 2017

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Background: It has been demonstrated that preeclampsia, a pregnancy-specific hypertension disorder, is characterized by high blood pressure (BP) and sympathetic overactivity. Increased reactive oxygen species (ROS) in the rostral ventrolateral medulla (RVLM), a key region for controlling sympathetic tone, has been reported to contribute to high level of BP and sympathetic outflow. The aim of the present study was to determine the role of the RVLM ROS in mediating the preeclampsia-associated cardiovascular dysfunction.Methods: The animal model of preeclampsia was produced by administration of desoxycorticosterone acetate (DOCA) to pregnant rats.Results: Compared with normal pregnant rats without DOCA treatment (NP), the protein concentration and norepinephrine excretion in 24-h urine, as well as BP in pregnant rats with DOCA treatment (PDS) were significantly increased. The levels of superoxide anion and the protein expression of NADPH oxidase subtype (NOX4) in the RVLM were significantly increased in PDS than in NP groups. Furthermore, microinjection of the superoxide dismutase (SOD) mimic Tempol (5 nmol) into the RVLM significantly decreased BP, heart rate, and renal sympathetic never activity in PDS but not in NP group.Conclusion: The present data suggest that high BP and sympathetic overactivity in preeclampsia rats is associated with increased oxidative stress in the RVLM via upregulation of NOX4 expression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia

et al. 2017

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“…The potent role of the renin angiotensin system (RAS) in pregnancy has been documented [39,[45][46][47][48]. The ACE2 receptor is critical for RAS since it is involved in the conversion of angiotensinogen into angiotensin 1, angiotensin 1 into angiotensin II, and angiotensin II into angiotensin (1-7) [49].…”

Section: Ace2 Receptor In Pregnancymentioning

confidence: 99%

Is pregnancy a risk factor of COVID-19?

Phoswa

Khaliq

2020

European Journal of Obstetrics & Gynecology and Reproductiv

141

105

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This review evaluates whether pregnancy is a risk factor for COVID-19 by looking at the expression of immune markers such as immune cells and cytokines in order to have a better understanding on the pathophysiology of the disease, thus reducing maternal deaths. Pregnant women are more at risk of contracting COVID-19 due to their weakened immune system. Studies demonstrate that COVID-19 is an immune condition which is marked by reduced lymphocytes and elevated selected proinflammatory cytokines. Similar immune expression has been demonstrated in pregnancy by several studies. In addition, the placenta has been shown to possess ACE2 receptors on the villous cytotrophoblast and the syncytiotrophoblast and findings suggest that the coronavirus enters the host cells via these ACE2 receptors. The immune response in pregnancy increases the risk of contracting COVID-19. Both normal pregnancy and COVID-19 are marked by decreased lymphocytes, NKG2A inhibitory receptors, and increased ACE2, IL-8, IL-10, and IP-10 it therefore safer to conclude that pregnancy is a risk factor for COVID-19 development. Furthermore, the presence of the ACE2 receptors in the placenta may increase the risk of mother to baby transmission of the virus. Therefore, more studies investigating the link between pregnancy and COVID-19 are needed.

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“…In pregnant women with PE, downregulated renin-angiotensin system (RAS) activity is observed, resulting in increased vascular responsiveness to angiotensin II [4]. The increased plasm levels of angiotensin (AGT) and angiotensin converting enzyme (ACE) in PE subjects lead to the augmentation of angiotensin II [5,54]; moreover, the pathophysiological effects of angiotensin II are enhanced by the upregulation of angiotensin II type 1 receptor (AT1R) [9], causing the dysregulation of blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…During normal pregnancy, the upregulation of renin and aldosterone triggered by the stimulation of the RAAS system maintains the balance of blood volume and blood pressure [4]; however, for PE subjects, depression of the RAAS system with increased vascular resistance was observed, suggesting its crucial role in the pathogenesis of PE [5]. Angiotensin (AGT), angiotensin converting enzyme (ACE), and angiotensin II type 1 receptor (AT1R) are the three pivotal nodes in the RAAS system.…”

Section: Introductionmentioning

confidence: 99%

Three polymorphisms of renin-angiotensin system and preeclampsia risk

Wang

Zhou

Liu

et al. 2020

J Assist Reprod Genet

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Purpose Some data suggest an association between the single nucleotide polymorphisms AGT T704C, ACE I/D, and AT1R A1166C and preeclampsia, but overall, the data are conflicting; the aim of our study was to discover a more stable and reliable association between these polymorphisms and PE risk. Methods A comprehensive literature search for this meta-analysis was conducted. Odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the strength, and heterogeneity test was conducted. Trial sequential analysis was also performed. Results A total of forty studies were finally included in our meta-analysis. The AGT T704C polymorphism was associated with PE risk in three genetic models (dominant OR = 1.33, 95%CI = 1.12–1.59; heterozygote OR = 1.26, 95%CI = 1.05–1.52; homozygote OR = 1.44, 95%CI = 1.14–1.83). No heterogeneity was observed in the three genetic models for the ACE I/D polymorphism. For subgroup analysis by geography, no significant association was detected. Significant associations were observed in mixed race, early-onset, late-onset, and more than 200 subgroups for the AT1R A1166C polymorphism; however, only one study was analyzed in these subgroups. Conclusions Our results indicated the AGT T704C and ACE I/D polymorphisms were associated with an increased risk of PE. Increased risks were also observed for the two polymorphisms in subgroups including Asians, Europeans, Caucasoid, and Mongoloid. Moreover, an increased PE risk with the ACE I/D polymorphism in the severe PE population was also detected. Regarding the AT1R A1166C polymorphism, weak associations were observed, but further studies are required.

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Association of gene polymorphisms of four components of renin-angiotensin-aldosterone system and preeclampsia in South African black women

Cited by 23 publications

References 24 publications

Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia

Oxidative Stress in the Rostral Ventrolateral Medulla Contributes To Cardiovascular Regulation in Preeclampsia

Is pregnancy a risk factor of COVID-19?

Three polymorphisms of renin-angiotensin system and preeclampsia risk

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