Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study

Sangrós, F. Javier; Torrecilla, Jesús; Giráldez‐García, Carolina; Carrillo, Lourdes; Mancera, José Jorge Celio; Mur, Teresa; Franch, Josep; Díez, J.M. Baena; Goday, Albert; Serrano, Rosario; García-Soidán, Francisco Javier; Cuatrecasas, Gabriel; Igual, Dimas; Moreno, Ana Hernández; Millaruelo, José Manuel; Carramiñana, Francisco; Ruiz, Manuel Antonio; Pérez, Francisco Carlos; Iriarte, Yon; Lorenzo, Ángela; González, María; Alvarez, B.; Barutell, Lourdes; Mayayo, M. Soledad; Castillo, Mercedes del; Navarro, Emma; Malo, Fernando; Cambra, Ainhoa; Lopez, R. D.; Gutiérrez, Mario; Gutierrez, Luisa Gutiérrez; Boente, Carmen; Mediavilla, Javier; Prieto, L.; Mendo, Luis; Mansilla, Marie; Ortega, Francisco J.; Borras, Antonia; Sánchez, L. Gabriel; Obaya, Juan Carlos; Alonso, Margarita; García, Francisco; Gutiérrez, Ángela Trinidad; Hernández, Ana; Suárez, D. Reyes; Álvarez, Juan Carlos García; Sáenz, Isabel; Martínez, Felipe; Casorrán, Ana; Ripoll, Jazmín; Salanova, Alejandro; Marín, María Teresa Martínez; Gutiérrez, Félix; Innerárity, Jaime; Álvarez, M. del Mar; Artola, Sara; Bedoya, Mariana; Poveda, Santiago; Álvarez, Fernando; Brito, M. Jesús; Iglesias, Rosario; Paniagua, Francisca; Nogales, Pedro; Gómez, Ángel; Rubio, José Félix; Duran, Mustafa; Sagredo, Julio; Gijón, M. Teresa; Rollán, M. Ángeles; Pérez, Pedro P.; Gamarra, Javier; Carbonell, F; García-Giralda, Luis; Antón, Joaquín; Flor, Manuel de la; Martínez, R.; Pardo, José Luis; Ruiz, Antonio García; Plana, Raquel; Macía, Ramón; Villaró, Mercè; Babace, Carmen; Torres, Jose; Blanco, Concepción; Jurado, Ángeles; Martín, José Luis Fernández; Navarro, Jorge; Sanz, G. Martínez; Colás, Rafael; Cordero, Blanca; Castro, Cristina De; Ibáñez, Mercedes; Monzón, A; Porta, Núria; Gómez, M. C.; Llanes, Rafael; Rodríguez, Juan José Ramos; Granero, Esteban; Sánchez, M. Isabel Gutiérrez; Martínez, Juan; Ezkurra, Patxi; Ávila, Luis Roberto Noa; Sen, Carlos de la; Rodríguez, Antonio Fernández; Buil, Pilar Redondo; Gabriel, Paula; Roura, Pilar; Tarragó, Eduard; Mundet, Xavier; Bosch, Remei; González, José; Bobé, M. Isabel; Mata, M. Rodríguez; Ruíz, Irene; López, F. Blanco; Birulés, M; Armengol, Oriol; Miguel, Rosa Mar de; Romera, Laura; Benito, B.; Piulats, Neus; Bilbeny, Beatriz; Cabré, Joan-Josep; Cos, Xavier; Pujol, Ramón M.; Seguí, Mateu; Losada, Carmen; Santiago, Ana; Muñoz, Pedro; Regidor, Enrique

doi:10.1016/j.rec.2017.04.035

Cited by 34 publications

(36 citation statements)

References 22 publications

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“…However, several randomized controlled trials (RCTs) and a recent meta-analysis on the effects of vitamin D supplementation on BMI did not seem to support this correlation [17][18][19][20]. On the other hand, several studies have suggested that central obesity is considered as a better predictor of several adverse health outcomes and mortality [21,22]. Thus, more attention should be paid to the current prevalence of central obesity.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations

et al. 2020

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Background: The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. However, there is insufficient knowledge to understand whether there is a causality between the two. Moreover, the impact of vitamin D supplementation on obesity indices has shown inconsistent outcomes. Objective: This meta-analysis aimed to assess whether vitamin D supplementation modified general and central obesity indices in apparently healthy populations. Methods: A systematic retrieval of relevant randomized controlled trials (RCTs) was undertaken using Pubmed, Embase, Web of Knowledge and Chinese National Knowledge Infrastructure databases. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were used to assess the changes in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and 25-hy-droxyvitamin D (25[OH]D) from baseline. Results: Twenty RCTs involving 3,153 participants reporting either BMI, WC, WHR or 25(OH)D met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant decreases in BMI (WMD =-0.09 kg/m 2 , 95% CI-0.19 to 0.01, p = 0.08), WC (WMD =-0.71 cm, 95% CI-1.58 to 0.16, p = 0.112) or WHR (WMD = 0.00, 95% CI-0.01 to 0.01, p = 0.749). However, in the subgroups of females, Asia region studies and intervention duration ≥6 months, a beneficial and significant reduction in BMI and WC was noted (all p < 0.026). On the other hand, pooled results showed that there was a significant increase in serum 25(OH)D levels (WMD = 13.20 ng/mL, 95% CI 9.83-16.58, p < 0.001) after vitamin D intervention. No publication bias was found in our study. Conclusions: Overall, supplementation with vitamin D produced no significant effect on the BMI, WC or WHR of healthy adults.

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Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations

et al. 2020

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“…Most of research found that the risk of hypertension increased with adiposity indices (22,23,(42)(43)(44)(45)(46). Moreover, a recent review conducted on the impact of adiposity on hypertension, included 46 studies of BMI and 12 of WC, found that obese males in lean populations were 45% more likely to be hypertensive compared to obese males in not-lean populations (47).…”

Section: Discussionmentioning

confidence: 99%

Gender-specific Predictive Ability for the Risk of Hypertension Incidence Related to Baseline Level or Trajectories of Adiposity Indices: Cohort Study of Functional Community in Beijing Urban from 2015 to 2019 year

Lu¹,

Dong²,

Sun³

et al. 2020

Preprint

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Background: Early prevention of hypertension is important for global cardiovascular disease morbidity and mortality. The current study aims to exploit better predictor for hypertension incidence related to baseline level or trajectories of adiposity indices, as well as the gender-specific effect.Methods: 6085 subjects from a functional community cohort in urban Beijing participated in our study. Restricted cubic splines were used to estimated nonlinear associations of BMI and WHtR as continuous variable with risk of hypertension. Stepwise logistic regression model was performed to estimate the RRs of adiposity indices and metabolic status, adjusted for covariates. Nomogram models and receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive power of BMI trajectory groups and WHtR trajectory groups. Further, all analysis were performed by gender.Results: The risk of hypertension incidence was significant related to BMI trajectory groups (persistent overweight: RR=1.99, 95%CI: 1.57-2.52; persistent obese: RR=3.07, 95%CI: 2.40-3.93; persistent the highest: RR=4.55, 95%CI: 3.37-6.14) and WHtR trajectory groups (persistent medium: RR=2.90, 95%CI: 2.23-3.77; persistent high: RR=4.48, 95%CI: 3.41-5.89; increasing to higher: RR=7.77, 95%CI:5.48-11.0). In total population, BMI trajectories and WHtR trajectories showed similar ability to predict the risk of hypertension incidence with AUC 0.713 and 0.720, respectively. After stratified by gender, BMI trajectories showed higher power in female than male butsimilar in WHtR trajectories (BMI trajectories: 0.762 vs. 0.662; WHtR trajectories: 0.769 vs. 0.663). Conclusions: BMI and WHtR trajectories have higher predictive power for hypertension incidence compared to baseline data. Women are more vulnerable to obese and abnormal MS than man.

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“…The percentage of women with obesity was higher than that of overweight and all were with increased waist circumference, thus representing a population group with a high risk of morbidity and mortality. These parameters are strongly associated with a higher prevalence of type 2 diabetes mellitus and cardiovascular diseases 27 . Increased visceral adipose tissue is associated with a number of metabolic abnormalities, including reduced glucose tolerance and insulin sensitivity and adverse lipid profiles 28 .…”

Section: Discussionmentioning

confidence: 99%

Effect of remote nursing monitoring on overweight in women: clinical trial

Palmeira

Mussi

Santos

et al. 2019

Rev. Latino-Am. Enfermagem

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Objective: to evaluate the effect of remote nursing monitoring on the improvement of anthropometric measurements of overweight women. Method: controlled, randomized clinical trial, carried out in a reference outpatient clinic for treatment of obesity. The baseline sample was composed of 101 women randomly assigned to two groups, 51 in the intervention group (IG) and 50 in the control group (CG). The IG received remote monitoring through telephone calls and conventional monitoring, and the CG received conventional monitoring. Women were assessed at the baseline and after three months of intervention. A paired t-test and analysis of covariance were used to evaluate intragroup differences in anthropometric measurements, and the statistical significance of 5% was adopted. Eighty one women completed the study. Results: in the intergroup comparison after the intervention, a reduction of 1.66 kg in the mean weight (p = 0.017) and of 0.66 kg/m2 in the mean BMI (p = 0.015) was found in the intervention group. There was a borderline statistically significant (p = 0.055) reduction of 2.5 cm in WC with in the intervention group. Conclusion: the remote monitoring was beneficial in reducing anthropometric measurements. RBR-3hzdgv.

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Association of General and Abdominal Obesity With Hypertension, Dyslipidemia and Prediabetes in the PREDAPS Study

Cited by 34 publications

References 22 publications

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations

Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations

Gender-specific Predictive Ability for the Risk of Hypertension Incidence Related to Baseline Level or Trajectories of Adiposity Indices: Cohort Study of Functional Community in Beijing Urban from 2015 to 2019 year

Effect of remote nursing monitoring on overweight in women: clinical trial

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