Association of Genetic Factors With Selected Measures of Physical Performance

Thompson, William R.; Binder‐Macleod, Stuart A.

doi:10.1093/ptj/86.4.585

Cited by 26 publications

(17 citation statements)

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“…Banyaknya tekanan kehidupan, stres interpersonal dan penolakan sosial, menjadi faktor risiko terbesar mengalami depresi. Depresi adalah suatu kondisi seseorang merasa sedih, kecewa saat mengalami suatu perubahan, kehilangan, kegagalan dan menjadi patologis ketika tidak mampu beradaptasi (A. K. Townsend et al, 2009) Depresi merupakan suatu keadaan yang mempengaruhi seseorang secara afektif, fisiologis, kognitif dan perilaku sehingga mengubah pola dan respon yang biasa dilakukan (Montgomery, 2011;Thompson & Binder-Macleod, 2006).…”

Section: Pendahuluanunclassified

Major Depressive Disorder: A Mini Review

Hadi

Wijayanti

Devianti

et al. 2017

Health Inf J Penelit

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Depresi adalah suatu kondisi seseorang merasa sedih, kecewa saat mengalami suatu perubahan, kehilangan, kegagalan dan menjadi patologis ketika tidak mampu beradaptasi. Depresi merupakan suatu keadaan yang mempengaruhi seseorang secara afektif, fisiologis, kognitif dan perilaku sehingga mengubah pola dan respon yang biasa dilakukan. Major Depressive Disorder merupakan penyakit heterogen ditandai dengan perasaan depresi, anhedonia, perubahan fungsi kognitif, perubahan tidur, perubahan nafsu makan, rasa bersalah yang terjadi selama dua minggu, digambarkan dengan hilangnya ketertarikan atau kesenangan akan aktivitas yang biasa dilakukan dan merupakan penyakit dengan konsekuensi neurobiologis yang melibatkan perubahan struktural, fungsional dan molekuler di beberapa daerah otak. Maladaptif respon saraf, penolakan sosial, psikologis, dan tingkat fisiologis berinteraksi satu sama lain dengan faktor kerentanan lainnya, seperti riwayat depresi, tingkat stres kehidupan, faktor genetik, akan meningkatkan kerentanan seseorang terhadap depresi.

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Section: Pendahuluanunclassified

Major Depressive Disorder: A Mini Review

Hadi

Wijayanti

Devianti

et al. 2017

Health Inf J Penelit

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“…The reaction of the human body to training loads is determined by diverse gene expression (Thompson & Binder-Macleod, 2006;Rupert, 2003). Much of the scientific interest in this area is focused on insulin-like growth factor (IGF-I), which has a wide spectrum of functions in the human body (Eliakim & Nemet, 2010).…”

Section: Introductionmentioning

confidence: 99%

The relationship between CA repeat polymorphism of the <i>IGF-1</i> gene and the structure of motor skills in young athletes

Karpowicz

Krych²,

Karpowicz

et al. 2018

Acta Biochim Pol

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The map of candidate genes that can potentially affect physical fitness becomes larger every year, and they are associated with such aspects as respiratory and cardiovascular stability; body build and composition - especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exercise intolerance.The aim of this study was to analyze the relationship between the CA repeat polymorphism of the P1 promoter of the IGF1 gene and the structure of motor skills in the two groups of Polish young athletes in 2007-2009. In this study, 350 young sportsmen representing different sports disciplines were examined (age = 15.5 ± 0.5 years), by genotyping the IGF1 gene and determining the structure of motor skills using the International Physical Fitness Test (IPFT) battery. The multiple stepwise regression was used to determine the impact of the investigated motor skills on the indicator of the overall physical fitness, measured by the total score of the International Physical Fitness Test (IPFT). The analysis showed some regularity related to the character of the IGF1 gene polymorphism. It can be concluded that the two groups of young boys athletes practicing various sports disciplines (kinds of physical exercise) displayed similar associations between CA repeat polymorphism of the P1 promoter of the IGF1 gene and the level of motor effects. Our results suggest that this polymorphism may be a genetic marker of the physical performance phenotype. We demonstrated that CA repeat polymorphism of the P1 promoter of the IGF1 gene was associated with strength predispositions in the homozygous and non-carriers groups. In the group who were heterozygous it was speed-strength aptitudes.

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“…Elite endurance athletes demonstrate existence of the II genotype, responsible for the power of endurance in athletes. (1), (29), whereas the DD genotype is frequently demonstrated in speed and strength athletes. (26), (32) Rightly called the gene of athletes, especially among top level and speed athletes, the ACTN3 gene is one of the most important genes in sports.…”

Section: Introductionmentioning

confidence: 99%

The Preliminary Phase of Junior Athlete Selection for the Sport Human Genome Project in Some Track and Field Events (Phase II)

2013

Journal of Applied Sports Science

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There is strong evidence that genes and genetic factors influence physical performance. This was why we developed the Sport Human Genome Project (SHGP), aiming at selecting junior players in some track and field events. Phase I of the project has already been completed and the present study aimed at implementing Phase II. This was done through identifying the genetic patterns of the ACE (DD,II) gene and the ACTN3 (RR,XX), and determining the best human elements according to genetic tests. The research sample consisted of 20 junior athletes with ages in the range 13.80 ± 0.410, who were selected in Phase I of the project. Morphological, physical and physiological measurements were taken of the sample, with the aim of finding those with genetic patterns for the ACE and ACTN3 genes through analysis of the DNA of blood sample using the polymerase chain reaction (PCR) and comparing the differences between groups of genetic patterns. Results showed the distribution of the genetic patterns of the ACE gene (genetic pattern ID: 70%; genetic pattern II: 10% and genetic pattern DD: 20%) and the genetic patterns of the ACTN3 gene (the genetic pattern RX: 60%; the genetic pattern RR: 20% and the genetic pattern XX: 20%) in the research sample. Another result was that genetic patterns are closely related to the selection of juniors. Individuals with the genetic pattern ACE II demonstrated greater ability in endurance activities, while those with the genetic pattern ACTN3 RR showed greater ability in speed activities. The best human elements constituted 30% of the sample size, based on genetic tests. The study recommended starting Phase III of the SHGP project on some track and field events.

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Association of Genetic Factors With Selected Measures of Physical Performance

Cited by 26 publications

References 50 publications

Major Depressive Disorder: A Mini Review

Major Depressive Disorder: A Mini Review

The relationship between CA repeat polymorphism of the <i>IGF-1</i> gene and the structure of motor skills in young athletes

The Preliminary Phase of Junior Athlete Selection for the Sport Human Genome Project in Some Track and Field Events (Phase II)

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