Association of Genetic Markers Contributing to Dyslexia Susceptibility in Indian Population

Reddy, Shilpa; Madireddy, Sujatha; Nair, Pooja

doi:10.21767/2171-6625.1000125

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Furthermore, the association of reading ability with allergic tendency was hypothesized based on the association between dyslexia and allergy 19 , 20 .…”

Section: Methodsmentioning

confidence: 99%

Allergic tendencies are associated with larger gray matter volumes

Takeuchi

Taki

Nouchi

et al. 2018

Sci Rep

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Allergic tendencies are associated with important cognitive and physiological factors, such as intelligence and mathematical abilities. Allergies are widely prevalent, especially in modern life, and the reason for its association with important cognitive variables is an intriguing scientific question. However, despite the unique characteristics of cognitive correlates of allergy, the anatomical correlates of allergy remain unknown. The aim of this study was to identify the associations between regional gray matter volume (rGMV) and allergic tendencies in young adults. In a study cohort of 1,219 healthy, educated young adults, we identified a positive correlation between total allergic tendency and rGMV in large anatomical clusters that mainly encompassed the dorsal part of the cerebral neocortex, right anterior insula, and cerebellum. Furthermore,both mean rGMV of the entire part of these clusters and total allergenic tendency showed a significant positive correlation with spatial ability. These results suggest the link among allergic tendencies, larger rGMV, and the better spatial ability in healthy, educated young adults.

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“…Furthermore, the association of reading ability with allergic tendency was hypothesized based on the association between dyslexia and allergy 19 , 20 .…”

Section: Methodsmentioning

confidence: 99%

Allergic tendencies are associated with larger gray matter volumes

Takeuchi

Taki

Nouchi

et al. 2018

Sci Rep

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“…Similar genotyping quality control (QC) procedures [24][25][26][27][28] were used for each cohort using PLINK v1.9 [29]. Specifically, individual samples were removed if more than 2% of SNPs failed genotyping (call rate < 98%), and individual SNPs were removed if they showed a Hardy-Weinberg Equilibrium (HWE) p-value < 0.001 [30][31][32][33][34], a minor allele frequency (MAF) < 1%, if more than 2% of samples were flagged as having failed genotype calling for any given SNP (call rate < 98%) and if any duplicate or triplicate discordance was detected.…”

Section: Genotype Data and Quality Controlmentioning

confidence: 99%

Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

Cismaru

Rudin

Ibáñez

et al. 2020

Genes

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Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic widely used in countries such as Switzerland and Germany. Notably, an underlying mechanism has not yet been fully elucidated and no predictive factors are known to identify at-risk patients. With the aim to identify genetic susceptibility variants to metamizole-induced agranulocytosis (MIA) and neutropenia (MIN), we conducted a retrospective multi-center collaboration including cases and controls from three European populations. Association analyses were performed using genome-wide genotyping data from a Swiss cohort (45 cases, 191 controls) followed by replication in two independent European cohorts (41 cases, 273 controls) and a joint discovery meta-analysis. No genome-wide significant associations (p < 1 × 10−7) were observed in the Swiss cohort or in the joint meta-analysis, and no candidate genes suggesting an immune-mediated mechanism were identified. In the joint meta-analysis of MIA cases across all cohorts, two candidate loci on chromosome 9 were identified, rs55898176 (OR = 4.01, 95%CI: 2.41–6.68, p = 1.01 × 10−7) and rs4427239 (OR = 5.47, 95%CI: 2.81–10.65, p = 5.75 × 10−7), of which the latter is located in the SVEP1 gene previously implicated in hematopoiesis. This first genome-wide association study for MIA identified suggestive associations with biological plausibility that may be used as a stepping-stone for post-GWAS analyses to gain further insight into the mechanism underlying MIA.

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Association of Genetic Markers Contributing to Dyslexia Susceptibility in Indian Population

Cited by 2 publications

References 18 publications

Allergic tendencies are associated with larger gray matter volumes

Allergic tendencies are associated with larger gray matter volumes

Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

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