Association of genetic polymorphisms in <i>IL-1R1</i> and <i>IL-1R2</i> genes with IgA nephropathy in the Han Chinese population

Xie, Maowei; Zhang, Daofa; Yin, Zhan; Yang, Xiaohong R.; Shu, Yan; Wang, Yanni; Huang, Haiyang; Han, Han; Li, Wenning; Fu, Keying; Su, Huiluan; Xu, Wentan; Wei, Jiali

doi:10.18632/oncotarget.16929

Cited by 21 publications

(28 citation statements)

References 32 publications

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“…Moreover, no significant association was also found between rs2072472 and the risk of ankylosing spondylitis (Xia et al, ) and endometriosis (Chun et al, ). Previous study reported that rs3218977 was found to be associated with a 0.71‐fold decrease risk of IgA nephropathy in the dominant model (GA‐GG vs. AA) (Xie et al, ). A case‐control association study found that the SNP rs3218977 was associated with an increased risk of aggressive periodontitis in the additive model in the Japanese (Kamei et al, ).…”

Section: Discussionmentioning

confidence: 96%

“…However, association studies indicated that rs4851527 was associated with decreased risk of tuberculosis (Ren et al, ) and ankylosing spondylitis (Xia et al, ). No significant association was found between the two SNPs (rs3218896 and rs2072472) and risk of IgA nephropathy (Xie et al, ), tuberculosis (Ren et al, ), and breast cancer (Zuo et al, ). Moreover, no significant association was also found between rs2072472 and the risk of ankylosing spondylitis (Xia et al, ) and endometriosis (Chun et al, ).…”

Section: Discussionmentioning

confidence: 99%

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Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Zhang

Cai

et al. 2019

Molec Gen & Gen Med

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Background Recently, many studies have identified that genetic factor plays a crucial role in endometrial cancer development. The purpose of this study is to investigate the influence of single nucleotide polymorphisms (SNPs) of IL‐1R2 on endometrial cancer susceptibility. Methods We performed a case‐control study that included 293 patients with endometrial cancer and 579 healthy controls. Six SNPs in the IL‐1R2 gene were genotyped using the Agena MassARRAY platform. Genetic models and haplotype analyses were used to assess the association between SNPs and endometrial cancer risk by computing odds ratios (ORs) and 95% confidence intervals (CIs). Results Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk. Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup. Conclusions These findings suggested that IL‐1R2 polymorphisms may contribute to the development of endometrial cancer. Further studies are required to confirm the results.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Zhang

Cai

et al. 2019

Molec Gen & Gen Med

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“…(Khoufache et al, ). Many studies reported that the IL1R2 as a protected factor can decrease the risk of many diseases, such as IgA nephropathy (Xie et al, ), Arthritis (Shimizu et al, ), and atherosclerosis (Pou et al, ). However, there were few researches about the IL1R2 genetic polymorphisms in previous studies, and no studies have been reported the genetic polymorphism of IL1R2 and HAPE risk.…”

Section: Discussionmentioning

confidence: 99%

Association between the IL1R2 rs2072472 polymorphism and high‐altitude pulmonary edema risk

Jin

Zhu

Bai

et al. 2019

Molec Gen & Gen Med

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Aim High‐altitude pulmonary edema (HAPE), as a multifactorial disease, is caused by stress failure and involves both environmental and genetic factors. Study shows that IL‐1 receptors can selectively decrease the oxygen arterial hypertension and influence the blood coagulation. So we evaluated whether genetic polymorphisms in IL1R1 and 1L1R2 genes are associated with the risk of HAPE in Chinese Han population. Methods Ten susceptible SNPs in the IL1R1 and IL1R2 genes were genotyped among 265 HAPE cases and 303 controls using the Agena MassARRAY platform. The associations of the SNP frequencies with HAPE were analyzed by chi‐square (χ 2 ) test/Fisher's test. The genetic models were used to evaluate associations. Results In the allele model, we found that rs2072472 was significantly associated with a 0.73‐fold decreased risk of HAPE (OR = 0.73, 95% CI = 0.55–0.97, p = 0.033). In the genetic model analysis, the rs2072472 in IL1R2 gene was associated with a 0.32‐fold decreased risk of HAPE in the codominant model, 0.67‐fold decreased risk of HAPE in the dominant model, 0.36‐fold decreasing the risk of HAPE in the recessive model, and 0.66‐fold decreased risk of HAPE in the log‐additive model, respectively. We found three candidate SNPs (rs11674595, rs4851527, and rs719250) in the IL1R2 gene have shown strong linkage, and none of the haplotypes was significantly associated with risk of HAPE. Conclusion These findings suggested that IL1R2 polymorphisms may contribute to the protection of HAPE.

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“…Recently, research has uncovered the genetic polymorphisms of IL1R1 and IL1R2 associated with several diseases. Variants in IL1R1 and IL1R2 have been reported with regard to their influence on knee osteoarthritis risk and IgA nephropathy in the Chinese Han population . Both IL1R1 and IL1R2 are multifunctional cytokines in inflammatory biological processes, which is strongly associated with thyroid carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…Variants in IL1R1 and IL1R2 have been reported with regard to their influence on knee osteoarthritis risk and IgA nephropathy in the Chinese Han population. [21][22][23] Both IL1R1 and IL1R2 are multifunctional cytokines in inflammatory biological processes, which is strongly associated with thyroid carcinogenesis. Their distinct roles in thyroid cancer development may actually be worthy of more attention.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

Xiong

Sun

et al. 2019

The Journal of Gene Medicine

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Background Thyroid carcinoma accounts for a large part of endocrine neoplasia and the relationship between inflammation and thyroid cancer has been validated previously. Two known receptors of interleukin (IL)‐1, IL‐1 receptor 1 (IL1R1) and IL‐1 receptor 2 (IL1R2), are implicated in numerous inflammatory responses. The present study aimed to assess the genetic polymorphisms of IL1R1 and IL1R2 with respect to thyroid cancer in the Chinese Han population. Methods Eleven single nucleotide polymorphisms of IL1R1 and IL1R2 were identified among 241 thyroid cancer patients and 463 controls using the Agena MassARRY method (http://www.internationalgenome.org/). Genetic models and haplotype analysis were carried out to evaluate the significant links between the variants and the risk of thyroid cancer. Results Logistic regression analyses revealed significant associations of rs3917225, rs2072472 and rs11674595 with susceptibility to thyroid cancer. Haplotype analysis presented two blocks of IL1R2, whereas no statistical significance existed. Conclusions These findings suggested that rs3917225, rs2072472 and rs11674595 are risk factors associated with the development of thyroid carcinoma in Chinese Han people.

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Association of genetic polymorphisms in IL-1R1 and IL-1R2 genes with IgA nephropathy in the Han Chinese population

Abstract: ABSTRACT

Cited by 21 publications

References 32 publications

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Association between the IL1R2 rs2072472 polymorphism and high‐altitude pulmonary edema risk

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

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