Association of Genetic Polymorphisms in a Sample of Iraqi Patients with Type1 Diabetes mellitus

Kandala, Nuha J.; Abdulridha, Ruaa Hameed

doi:10.20546/ijcmas.2016.507.083

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…The results indicated that there was a significant decrease in TID The current finding was compatible with Nuha et al (2016) who found that the high frequency onset of T1D was recorded at the child hood before the age of puberty [27]. Also, the study was compatible with the Majeed.…”

Section: Distribution Of Type 1 Diabetes Patients According To Age Gr...supporting

confidence: 91%

The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

Ammar¹,

Al-Izzi²,

Mousa³

2022

Tikrit J. Pure Sci.

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Previous studies indicated that elevated serum levels of Interleukin -18 (IL-18) and human cytomegalovirus (HCMV) antibodies have a fundamental role in the pathogenesis of Type I diabetic mellitus T1DM. Therefore, the aim of the current study was to investigate the possible overlap between human cytomegalovirus (HCMV) and Interleukin-18 (IL-18) with the pathogenesis of T1DM. The serum of (45) T1DM patients and (45) healthy controls were used to detect IL-18 levels with an ELISA Kit and detect HCMV with cobas c411 apparatus for detect IgM and IgG HCMV. The results showed that the levels of IL-18 and human CMV IgM, IgG were significantly higher in patients with type 1 diabetes compared to the control group (45.8773 ±12.196 and 0.52 ± 0.25, 63.52 ±13.0 pg/ml for patients respectively) versus (12.611 ±3.9 and 0.11 ±0.01, 0.261 ±0.68 pg/ml for healthy subjects, respectively); The values were at P value ≤ 0.05. The results of the data concluded that there was a significant increase of IL-18 and human CMV IgM, IgG in the serum of the patient group compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T. These data concluded that there was a significant increase in serum IL-18 and HCMV Abs, compared to the lower levels in the control group, indicating that these markers may be involved in the pathogenesis and development of T1DM.

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Section: Distribution Of Type 1 Diabetes Patients According To Age Gr...supporting

confidence: 91%

The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

Ammar¹,

Al-Izzi²,

Mousa³

2022

Tikrit J. Pure Sci.

View full text Add to dashboard Cite

show abstract

Association of Genetic Polymorphisms in a Sample of Iraqi Patients with Type1 Diabetes mellitus

Cited by 1 publication

References 17 publications

The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

The Role of IL-18 and Human Cytomegalovirus in Type 1 Diabetes Mellitus in Thi-Qar Province

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