Association of genetic polymorphisms with embryonic mortality in the chicken: II. The B blood-group system and the pure and crossbred progeny of two populations

Abstract

We have studied the association of the ten possible B blood-group genotypes with mortality during incubation in the 1966 generation of two relatively noninbred populations of Light Sussex chickens. These were related substrains 6D and 6F derived in the 1964 generation by equal division of strain 6, which we had previously studied in its 1962 generation. The B blood-group genotypes of zygotes but not of dams were associated with marked mortality differences in 6F, while in 6D almost no differences were found. Comparisons of the findings in 6D and 6F with the results previously published for the ancestor strain 6, after adjustment for overall between-population differences, showed marked changes between 6 and 6F in the mortalities associated with the five most frequent genotypes. In four of these, the mortalities in 6D were about half way between those in 6 and 6F. Taken together, these results provide evidence that the selective pressures on the B locus from differential embryonic mortality vary from generation to generation and even between populations differing apparently only slightly in environment and genetic composition.In progeny of crosses between females from 6D and 6F with males from 5D and 5F respectively, the latter being two related Rhode Island Red/New Hampshire substrains, embryonic mortality was much lower than in the pure matings within 6D and 6F, and only a few associations with B blood-group genotypes of zygotes were found.The results are discussed in relation to the general lack of association of polyallelic polymorphisms with aspects of fitness reported by other workers; and the importance is stressed of studying associations of genotypes rather than genes or serological factors.

Perspectives for Poultry Genetics in the Age of Molecular Biology

“…Apart from certain specific relationships with disease resistance (see Section (v) below) the general trend of results has been variable and inconsistent like the allozyme data. There is fairly general agreement among authors on associations of B locus variation with fitness and production traits (Gilmour, 1960;Briles, 1960;Gilmour, 1962;Allen and Gilmour, 1962;Morton et al, 1965;Gilmour and Morton, 1970;Nordskog, Rishell and Briggs, 1973). While heterozygote advantage was common at the B, C, L and N loci, homozygote advantage was reported at the A locus (Gilmour, 1960;De Silva, 1965), but Seet and Briles' (1970) results indicated heterozygote advantage of A sires and homozygote advantage of B sires for egg hatchability and sire fertility respectively.…”

Research on Qualitative Genes of Poultry in the United States Part 2

“…A possible association between a bursa antigen and susceptibility to leukosis-sarcoma virus is being investigated. Gilmour and Morton (1970) studied the association of the ten possible B blood-group genotypes with mortality during incubation in two noninbred populations of Light Sussex chickens. The results indicated that the selective pressures on the B locus from differential embryonic mortality vary from generation to generation and even between populations that differ only slightly in environment and genetic composition.…”

Analysis of gene action in the control of body weight and tail length in the mouse

“…Such epistasis is measurable with suitable experimental design. For example, associations may be sought between groups of polymorphic loci and components of fitness, as we have already done (Morton et al, 1965;Gilmour and Morton, 1970). Another approach is to analyse the forms of epistasis in the control of continuously varying traits over a wide range of genotypes, to see which forms are associated with traits determining fitness; in this context the observation of balancing dominance and dominance x dominance interaction effects (Morton, 1964) is of obvious significance.…”