Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders

Pełka-Wysiecka, Justyna; Ziętek, Joanna; Grzywacz, Anna; Kucharska-Mazur, Jolanta; Bieńkowski, Przemysław; Samochowiec, Jerzy

doi:10.1016/j.pnpbp.2012.04.009

Cited by 27 publications

(30 citation statements)

References 49 publications

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“…The homozygous Gly49Gly genotype is extremely rare [22], and was not present in our population. Regarding the Val158Met-COMT polymorphism, there are sparse data on the normal frequency in healthy white subjects; however, Pełka-wysiecka et al [23] found the Val158Val genotype in 14.2%, the heterozygous in 60.5%, and the Met158Met genotype in 25.3% in a Polish population, which would mean that in our patients, heterozygous are less frequent but Val158Val genotype is more frequent. Similarly, in Swedish men, 19.6% Val158Val, 54.6% heterozygous, and 25.7% Met158Met genotype carriers were found [24], while others found a more even distribution among whites [25].…”

Section: Discussionmentioning

confidence: 63%

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

Dhein

Dohmen

Sauer

et al. 2017

Med Sci Monit Basic Res

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BackgroundThere is a long-standing debate about the role of beta-adrenoceptor polymorphisms in the cardiovascular system. We wanted to elucidate whether β1-adrenoceptor-polymorphisms affects the postoperative catecholamine consumption and the length of intermediate care unit stay in patients undergoing cardiac surgery, and whether this might be enhanced or attenuated by catechol-O-methyl-transferase (COMT) polymorphism.Material/MethodsWe included 116 patients (63±1.2 years; 34% females; 81±1 kg) undergoing cardiac surgery. We assessed Arg389Gly and Ser49Gly-β1-adrenoceptor (B1AR) polymorphism together with Val158Met-COMT polymorphism by real-time PCR using fluorescence resonance energy transfer (PCR-FRET). The preoperative risk was assessed by EuroSCORE. In addition, we measured the endogenous preoperative epinephrine and norepinephrine plasma concentrations using an electrochemical HPLC method.Results84.6% were homozygous for Ser49Ser, 52.1% homozygous for Arg389Arg B1AR, and 32.5% for Val158Val-COMT, while 15.4% showed Ser49Gly B1AR, 38.5% Arg389Gly-B1AR, and 35.6% Val158Met-COMT. We found that the Gly49-variant, the Gly389-variant, and the Val158-COMT-variant were associated with higher postoperative norepinephrine consumption. All patients carrying the Val158-COMT allele exhibited higher preoperative norepinephrine concentrations. Moreover, we found that both β1-adrenoceptor polymorphisms were associated with a longer stay in hospital, which was modulated by the COMT polymorphism.ConclusionsThese data show that the β1-adrenoceptor polymorphisms, together with the COMT polymorphism, affect norepinephrine consumption and stay in hospital in a situation of enhanced cardiovascular stress, reflected here by the postoperative period after cardiac surgery. Moreover, we conclude that patients with the Val158-COMT genotype exhibit higher endogenous resting plasma norepinephrine levels.

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Section: Discussionmentioning

confidence: 63%

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

Dhein

Dohmen

Sauer

et al. 2017

Med Sci Monit Basic Res

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“…Indeed, the character scale cooperativeness is based on the concept of self as an integral part of humanity or society; with feelings of community, compassion, conscience, and charity (Kose 2003), in essence, these are all empathic processes. As mentioned earlier, homozygous 9/9VNTR DAT genotypes (higher dopamine levels) display the lowest scores on cooperativeness and compassion (Pełka-Wysiecka et al 2012). Further, CC genotype carriers – associated with higher dopamine beta-hydroxylase (DBH) activity resulting in higher dopamine turnover to norepinephrine – manifest greater empathic ability compared to CT/TT genotypes (Gong et al in press).…”

Section: Discussionmentioning

confidence: 73%

The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females

2014

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ObjectivesAlthough the Val158Met catechol-O-methyltransferase (COMT) gene has been linked with the temperament dimension Novelty Seeking (NS), new insights in this polymorphism might point to a major role for character features as well. Given that individual life experiences may influence Val158 and Met158 allele carriers differently it has been suggested that the character trait cooperativeness could be implicated.Case reportA homogeneous group of eighty right-handed Caucasian healthy female university students were assessed with the TCI and genotyped for the COMT Val158Met polymorphism (rs4680). Gene determination showed that eighteen were Val158 homozygotes, forty-four Val/Met158 heterozygotes, and eighteen were Met158 homozygotes. All were within the same age range and never documented to have suffered from any neuropsychiatric illness. Bonferroni corrected non-parametric analyses showed that only for the character scale cooperativeness Val158 homozygotes displayed significant higher scores when compared to Met158 homozygotes. No significant differences on cooperativeness scores were found between Val158 and Val/Met158 carriers or between Met158 and Val/Met158 carriers. No differences were observed for the COMT Val158Met polymorphism and the other temperament and character scales.ConclusionsOur findings support the assumption that the Val158Met single nucleotide polymorphism (SNP) influences character traits and not only temperament. Our results add to the notion that Val158 homozygotes are considered to be helpful and empathic and it suggest that these cooperativeness character traits are related to the dopaminergic system.

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“…In addition, there is increase evidence of the association between the 5-HTT and DRD2/DRD4 polymorphisms with character dimensions which, according to Cloninger's Theory, are acquired during the development through socio-cultural learning and not as genetically determined as the temperament dimensions (Cloninger et al 1994). Studies from different cultural populations reported that healthy subjects carriers of the short allele within the 5-HTT showed lower scores in all the Cloninger's character dimensions, including Self-Transcendence (Ham et al 2004), Self-Directedness (Gonda et al 2009;Saiz et al 2010;Calati et al 2014) and Cooperativeness (Pełka-Wysiecka et al 2012). Similarly, for the DRD2 polymorphism, Tsuchimine et al (2012) found that the less frequent allele was associated with significant lower scores in the Self-Directedness scale (Table 1).…”

mentioning

confidence: 91%

The association between the serotonin and dopamine neurotransmitters and personality traits

Delvecchio

Altamura

Brambilla

2016

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences appears in each issue of the Journal to stress the relevance of epidemiology for behavioral neurosciences, reporting the results of studies that explore the use of an epidemiological approach to provide a better understanding of the neural basis of major psychiatric disorders and, in turn, the utilisation of the behavioural neurosciences for promoting innovative epidemiological research.The ultimate aim is to help the translation of most relevant research findings into every-day clinical practice. These contributions are written in house by the journal's editorial team or commissioned by the Section Editor (no more than 1000 words, short unstructured abstract, 4 key-words, one Table or Figure and up to ten references). Paolo Brambilla, Section EditorThe association between the serotonin and dopamine neurotransmitters and personality traits Evidence from previous studies has reported that complex traits, including psychiatric disorders, are moderately to highly heritable. Moreover, it has also been shown that specific personality traits may increase the risk to develop mental illnesses. Therefore the focus of the research shifted towards the identification of the biological mechanisms underpinning these traits by exploring the effects of a constellation of genetic polymorphisms in healthy subjects. Indeed, studying the effect of genetic variants in normal personality provides a unique means for identifying candidate genes which may increase the risk for psychiatric disorders. In this review, we discuss the impact of two of the most frequently studied genetic polymorphisms on personality in healthy subjects, the 5-HTT polymorphism of the serotonin transporter and the DRD2/DRD4 polymorphisms of the D2/D4 dopamine's receptors. The main aims are: (a) to highlight that the study of candidate genes provides a fruitful ground for the identification of the biological underpinnings of personality without, though, reaching a general consensus about the strength of this relationship; and (b) to outline that the research in personality genetics should be expanded to provide a clearer picture of the heritability of personality traits.

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Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders

Cited by 27 publications

References 49 publications

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females

The association between the serotonin and dopamine neurotransmitters and personality traits

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Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders

Cited by 27 publications

References 49 publications

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

Effects of β-Adrenoceptor and Catechol-O-Methyl-Transferase (COMT) Polymorphism on Postoperative Outcome in Cardiac Surgery Patients

The influence of COMT Val158Met genotype on the character dimension cooperativeness in healthy females

The association between the serotonin and dopamine neurotransmitters and personality traits

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The influence of COMT Val¹⁵⁸Met genotype on the character dimension cooperativeness in healthy females