Association of Genetic Variants in IL6 Gene (rs1800795) with the Concentration of Inflammatory Markers (IL-6, hs-CRP) and Superoxide Dismutase in the Blood of Patients with Acute Pancreatitis—Preliminary Findings

Ołdakowska, Monika; Ściskalska, Milena; Kępińska, Marta; Marek, Grzegorz; Milnerowicz, Halina

doi:10.3390/genes13020290

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…The reason why people from control group higher concentrations of IL-6 may also be that the of erythrocytes from this group showed statistically signi cant higher concentration of cadmium compared to the diabetic group, which would indicate that people in this group accumulate cadmium which has a pro-in ammatory effect. Ołdakowska et al (49) showed a increase in IL-6 concentration in smokers compared to non-smokers in the group of patients with acute pancreatitis. In addition, there were more in control group and in the obese group than in the diabetic group.…”

Section: Discussionmentioning

confidence: 97%

The concentrations of interleukin-6, insulin, and glucagon in the context of obesity and type 2 diabetes, and single nucleotide polymorphisms in IL6 and INS genes

Król

Urbanowicz

Kępińska

2023

Preprint

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Background Obesity and diabetes are a problem of modern medicine. Although the environmental factors contributing to the development of these diseases are widely known, research into genetic factors is still ongoing. At the same time, the role of inflammation in the pathophysiology of obesity and diabetes is increasingly emphasized. Therefore, the purpose of this study was to investigate the influence of two selected polymorphisms (rs1800795, rs3842729) on the development of obesity and type 2 diabetes. Methods In this study, 118 participants were examined, including a control group (non-obese and non-diabetic group), an obese group, and a diabetic group. Genotype analysis was performed using the PCR-RFLP method. Results It has been shown that in patients with the G/G genotype within the rs1800795 polymorphism (IL6), the chance of developing type 2 diabetes is several times lower compared to patients with the G/C and C/C genotypes. However, the rs3842729 polymorphism (INS) does not directly affect the risk of obesity or type 2 diabetes (T2D), although elevated insulin concentrations have been observed in obese and diabetic patients. Conclusions These results confirm the impact of the rs1800795 polymorphism on the development of diabetes, however, this relationship is more complex and requires further research on other factors.

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Section: Discussionmentioning

confidence: 97%

The concentrations of interleukin-6, insulin, and glucagon in the context of obesity and type 2 diabetes, and single nucleotide polymorphisms in IL6 and INS genes

Król

Urbanowicz

Kępińska

2023

Preprint

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“…Te reason why people from the control group had higher concentrations of IL-6 may also be that the lysate of erythrocytes from this group showed a statistically signifcant higher concentration of cadmium compared to the diabetic group, which would indicate that people in this group accumulate cadmium which has a proinfammatory efect. Ołdakowska et al [50] showed a 1.5-fold increase in IL-6 concentration in smokers compared to nonsmokers in the group of patients with acute pancreatitis. In addition, there were more smokers in the control group and in the obese group than in the diabetic group.…”

Section: Discussionmentioning

confidence: 97%

The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes

Król-Kulikowska,

Urbanowicz,

Kepinska

2024

Journal of Obesity

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Obesity and diabetes are a problem of modern medicine. Although the environmental factors contributing to the development of these diseases are widely known, research into genetic factors is still ongoing. At the same time, the role of inflammation in the pathophysiology of obesity and diabetes is increasingly emphasized. Therefore, the purpose of this study was to investigate the influence of two selected polymorphisms (rs1800795 and rs3842729) on the development of obesity and type 2 diabetes. In this study, 118 participants were examined, including a control group (nonobese and nondiabetic group), an obese group, and a diabetic group. Genotype analysis was performed using the PCR-RFLP method. It has been shown that in patients with the G/G genotype within the rs1800795 polymorphism (IL6), the chance of developing type 2 diabetes is several times lower compared to patients with the G/C and C/C genotypes. However, the rs3842729 polymorphism (INS) does not directly affect the risk of obesity or type 2 diabetes (T2D), although elevated insulin concentrations have been observed in obese and diabetic patients. These results confirm the impact of the rs1800795 polymorphism on the development of diabetes; however, this relationship is more complex and requires further research on other factors.

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“…However, the pancreatitis activity scoring system (PASS), recently developed by several pancreatitis experts, has been shown to be useful in the assessment of MSAP 5 , although there are few clinical studies of it. Given that AP is accompanied by a significant systemic inflammatory response 6 , we investigated the value of serum CRP and IL-6 assay combined with PASS in assessing the severity of AP patients.…”

Section: Introductionmentioning

confidence: 99%

Value of serum CRP and IL-6 Assays combined with Pancreatitis activity scoring system for assessing the severity of patients with acute pancreatitis

Xu,

Hu,

2023

Pak J Med Sci

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Objective: To evaluate the accuracy of serum CRP and IL-6 assays combined with the pancreatitis activity scoring system (PASS) in assessing the severity of patients with acute pancreatitis (AP). Methods: This was a retrospective study of 223 patients with AP admitted to Baoding Lianchi District People’s Hospital between February 2021 and 2023. They were classified into three categories: mild AP (MAP), moderate severe AP (MSAP) and severe AP (SAP). The differences, accuracy and sensitivity of the individual assays, and the three in combination, were compared and analysed in the three groups. Results: PASS scores, IL-6 and CRP levels were significantly higher in the SAP and MSAP groups compared to those in the MAP group, with statistically significant differences between the three groups. Multi-factorial logistic regression analysis suggested that PASS, IL-6 and CRP were correlated indicators of AP severity. The combination of the three assays was higher than that of the PASS score, IL-6 and CRP alone, suggesting optimal diagnostic efficacy when the three assays were combined. Moreover, the levels of PASS score, IL-6 and CRP showed a positive correlation with the degree of disease severity. Conclusions: The serum CRP, IL-6 and PASS scores were significantly elevated in AP patients and showed a positive correlation with disease severity, all of which are beneficial for the diagnosis of AP. PASS is superior to CRP and IL-6 in the assessment of AP. The combination of the three assays can achieve a far superior diagnostic efficacy to that of the individual index assays. doi: https://doi.org/10.12669/pjms.40.1.7550 How to cite this: Xu F, Hu X, Li S. Value of serum CRP and IL-6 Assays combined with Pancreatitis activity scoring system for assessing the severity of patients with acute pancreatitis. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7550 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Association of Genetic Variants in IL6 Gene (rs1800795) with the Concentration of Inflammatory Markers (IL-6, hs-CRP) and Superoxide Dismutase in the Blood of Patients with Acute Pancreatitis—Preliminary Findings

Cited by 7 publications

References 44 publications

The concentrations of interleukin-6, insulin, and glucagon in the context of obesity and type 2 diabetes, and single nucleotide polymorphisms in IL6 and INS genes

The concentrations of interleukin-6, insulin, and glucagon in the context of obesity and type 2 diabetes, and single nucleotide polymorphisms in IL6 and INS genes

The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes

Value of serum CRP and IL-6 Assays combined with Pancreatitis activity scoring system for assessing the severity of patients with acute pancreatitis

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